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Engineering an Injectable Scaffold with Enhanced ECM Mimicry for Cell Delivery …

Kirwale(SS),Jaiswal(R),Sahu(P),Verma(V),Yada… ACS Biomater Sci Eng 2025-10-13

...Col1A1, and TGF-β. In vivo application of PDF-loaded CHyCoGel significantly enhanced wound healing, epithelialization, a...

Integrative multi-omics and causal inference reveal periodontal ligament cell-m…

Jiang(Y),Zhou(J),Huang(Y),Bai(Y),Chen(X),Hua… Prog Orthod 2025-10-20

...COL1A1/COL2A1 downregulation. Single-cell RNA sequencing identified Cd40+ macrophages enriched in IL-17 signaling. MR ca...

Runx1 drives cardiac fibrosis and heart failure through epigenetic activation o…

An(J),Zhou(W),Xia(L),Wang(Q),Peng(X),Zheng(Z… BMC Cardiovasc Disord 2025-10-21

...Col1a1), and reduced CF migration and proliferation. PostnCre-Runx1F/F mice exhibited improved cardiac function, reduced...

Tacrolimus modulates the PI3K AKT mTOR pathway in retinal epithelial cells unde…

Kiełbasińska(A),Grabarek(BO),Janiszewska-Bil… Sci Rep 2025-10-21

...COL1A1. LPS treatment led to strong upregulation of inflammatory and fibrotic genes, while tacrolimus reversed or attenu...

Exosomes derived from Schwann cells (SCDE) promote tendon repair through the PT…

Chunbo(L),Jia(L),Jian(Z),Yaxian(G),Chenwei(G… J Orthop Surg Res 2025-10-21

...COL1A1, p-AKT, PTEN, and other markers.In the in vivo experiments, a rat model of 1/3 patellar tendon defect was establi...

Spatially distinct ECM-producing fibroblasts and myonuclei orchestrate early ad…

Møbjerg(A),Steffen(D),Schjerling(P),Jakobsen… Am J Physiol Cell Physiol 2025-12-01

...COL1A1 and DCN. Three of these subtypes were localized to the tendon and responded to exercise: two were spatially restr...

Investigation of multifaceted wound healing effect of exopolysaccharide (EPS) p…

Demir(A),Aslim(B) Sci Rep 2025-10-21

...COL1A1 in L929 cells. L-EPS affected the TGF-β1/Smad signaling pathway by increasing the expression of the TGF-β1, Smad2...

Senolytic Combination of Dasatinib and Quercetin Promotes Tendon-to-Bone Healin…

Cai(Z),Wang(H),Hu(J),Qu(C),Chen(S),Liu(X),Fa… Am J Sports Med 2025-11-00

...Col1a1, Tnmd, and Scx) genes. Histological analysis revealed that the aged + DQ group had decreased cellular senescence ...

Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarth…

Bomer(Nils),den Hollander(Wouter),Ramos(Yola… Ann Rheum Dis 2016-05-04

...COL1A1). Given their concurrent and significant upregulation of expression, this process is likely mediated via HIF-2α/R...

Histological and molecular-biological analyses of poly(3-hydroxybutyrate) (PHB)…

Gredes(Tomasz),Gedrange(Tomasz),Hinüber(Clau… Ann Anat 2016-02-01

...Col1a1 and VEGFA in cranium defects after treatment with PHB patches compared to untreated bony defects of the same cran...

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