CFLARGene Detail-Gene Database-Genelibs

CFLAR (CASP8 and FADD like apoptosis regulator)

symbol:: CFLAR
locus group:: protein-coding gene
location:: 2q33.1
gene_family:: Endogenous ligands
alias symbol:: CASH|Casper|CLARP|FLAME|FLIP|I-FLICE|MRIT|c-FLIP|cFLIP
alias name:: None
entrez id:: 8837
ensembl gene id:: ENSG00000003402
ucsc gene id:: uc002uxb.5
refseq accession:: NM_003879
hgnc_id:: HGNC:1876
approved reserved:: 1999-05-07

2q33.1

ChineseEnglish

The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]

OMIM entry for CFLAR Wikipedia entry for CFLAR

Nucleotide sequence of CFLAR:[NCBI]

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Protein Sequence

1MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL
41LDILRERGKL SVGDLAELLY RVRRFDLLKR ILKMDRKAVE
81
THLLRNPHL VSDYRVLMAE IGEDLDKSDV SSLIFLMKDY
121MGRGKISKEK SFLDLVVELE KLNLVAPDQL DLLEKCLKNI
161H
RIDLKTKI QKYKQSVQGA GTSYRNVLQA AIQKSLKDPS
201NNFRLHNGRS KEQRLKEQLG AQQEPVKKSI QESEAFLPQS
241IP
EERYKMK SKPLGICLII DCIGNETELL RDTFTSLGYE
281VQKFLHLSMH GISQILGQFA CMPEHRDYDS FVCVLVSRGG
321SQS
VYGVDQ THSGLPLHHI RRMFMGDSCP YLAGKPKMFF
361IQNYVVSEGQ LEDSSLLEVD GPAMKNVEFK AQKRGLCTVH
401READ
FFWSL CTADMSLLEQ SHSSPSLYLQ CLSQKLRQER
441KRPLLDLHIE LNGYMYDWNS RVSAKEKYYV WLQHTLRKKL
481ILSYT

结构预测来自 AlphaFold DB（UniProt: O15519），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

SNP variants of CFLAR: Showing partial SNPs

rs719125 rs719126 rs741288 rs1135266 rs1981726 rs2041765 rs2041766 rs2068559 rs2268791 rs2348483 rs2540456 rs3769828 rs3769829 rs4482462 rs4487072 rs4673061 rs4991112

Tissue expression of CFLAR: [UniProt]

Forward Primer

Forward Tm

Reverse Primer

Reverse Tm

Score

ACGTATCTTGAAGATGGACAG

58

CATCAGCACTCTATAGTCCG

57

GTTACAGGAATGTTCTCCAAGC

60

CTTCTCCCATTATGGAGCCT

59

TTGCCTCAGAGCATACCTG

60

TCATTGCCAATGCAATCGA

59

GTTACAGGAATGTTCTCCAAGC

60

CTTCTCCCATTATGGAGCCT

59

GGAGATCCAGTGGGAAGAG

59

GTTGTGAGTCCTCTGGAGG

59

GTTACAGGAATGTTCTCCAAGC

60

CTTCTCCCATTATGGAGCCT

59

GCTTATAGAAGAGACATCTTGAGAG

59

TGATGGATGACTTCAGCAG

57

GTACAAGCAGTCTGGTGGA

59

ATGAAGAATATAAAGGGACGCG

59

GTTACAGGAATGTTCTCCAAGC

60

CTTCTCCCATTATGGAGCCT

59

AAGCAGTCTGTTCAAGGAG

57

ATTTGAAGGATCCTTGAGACTC

58

Transcription Factors

Target Gene

Interaction Type

PubMed References

ATM

CFLAR

Activation

19351839

ATM

CFLAR

Repression

20876284

DEDD

CFLAR

Unknown

17193921

HDAC9

CFLAR

Activation

20087862

HDAC9

CFLAR

Repression

15540114

IRF8

CFLAR

Unknown

19155307

MYC

CFLAR

Repression

20348907

NFKB1

CFLAR

Activation

15750764; 15986355; 19343319

NFKB1

CFLAR

Repression

15723831

NFKB1

CFLAR

Unknown

18222423

Subcellular localization of CFLAR (and its protein):

[UniProt] [GenomeNet]

plasma membrane
cytoplasm
extracellular
golgi
vesicle
cytoskeleton
endoplasmic reticulum
nucleus
endosome
lysosome
mitochondrion

Gene Ontology (GO) terms for CFLAR:

GO ID

Protein

Source DB

GO:0004197

A0A0A0MR92 (UniProtKB)

IEA

GO:0006508

A0A0A0MR92 (UniProtKB)

IEA

GO:0006915

A0A0A0MR92 (UniProtKB)

IEA

GO:0042981

A0A0A0MR92 (UniProtKB)

IEA

GO:0042981

C9J408 (UniProtKB)

IEA

GO:0042981

C9J4Q0 (UniProtKB)

IEA

GO:0042981

C9JSU3 (UniProtKB)

IEA

GO:0042981

C9JV51 (UniProtKB)

IEA

GO:0042981

E9PAP3 (UniProtKB)

IEA

GO:0042981

F8WBH9 (UniProtKB)

IEA

GO:0042981

M0QY57 (UniProtKB)

IEA

GO:0042981

M0QYM0 (UniProtKB)

IEA

GO:0042981

M0R1A8 (UniProtKB)

IEA

GO:0002020

O15519 (UniProtKB)

IPI

GO:0002020

O15519 (UniProtKB)

IPI

GO:0005123

O15519 (UniProtKB)

IEA

GO:0005515

O15519 (UniProtKB)

IPI

GO:0005515

O15519 (UniProtKB)

IPI

GO:0005515

O15519 (UniProtKB)

IPI

GO:0005515

O15519 (UniProtKB)

IPI

GO:0005515

O15519 (UniProtKB)

IPI

GO:0005515

O15519 (UniProtKB)

IPI

GO:0005515

O15519 (UniProtKB)

IPI

GO:0005515

O15519 (UniProtKB)

IPI

GO:0005515

O15519 (UniProtKB)

IPI

GO:0005515

O15519 (UniProtKB)

IPI

GO:0005515

O15519 (UniProtKB)

IPI

GO:0005515

O15519 (UniProtKB)

IPI

GO:0005515

O15519 (UniProtKB)

IPI

GO:0005515

O15519 (UniProtKB)

IPI

GO:0005515

O15519 (UniProtKB)

IPI

GO:0005737

O15519 (UniProtKB)

IDA

GO:0005829

O15519 (UniProtKB)

TAS

GO:0005829

O15519 (UniProtKB)

TAS

GO:0005829

O15519 (UniProtKB)

TAS

GO:0005829

O15519 (UniProtKB)

TAS

GO:0005829

O15519 (UniProtKB)

TAS

GO:0005829

O15519 (UniProtKB)

TAS

GO:0006508

O15519 (UniProtKB)

IEA

GO:0006915

O15519 (UniProtKB)

IMP

GO:0007519

O15519 (UniProtKB)

ISS

GO:0008047

O15519 (UniProtKB)

IDA

GO:0014732

O15519 (UniProtKB)

ISS

GO:0014842

O15519 (UniProtKB)

ISS

GO:0014866

O15519 (UniProtKB)

ISS

GO:0016032

O15519 (UniProtKB)

IEA

GO:0031264

O15519 (UniProtKB)

IDA

GO:0031265

O15519 (UniProtKB)

IEA

GO:0032403

O15519 (UniProtKB)

IEA

GO:0043066

O15519 (UniProtKB)

TAS

GO:0043085

O15519 (UniProtKB)

IEA

GO:0043123

O15519 (UniProtKB)

IEP

GO:0043403

O15519 (UniProtKB)

ISS

GO:0045121

O15519 (UniProtKB)

IEA

GO:0051092

O15519 (UniProtKB)

ISS

GO:0060544

O15519 (UniProtKB)

IDA

GO:0097194

O15519 (UniProtKB)

IBA

GO:0097200

O15519 (UniProtKB)

IBA

GO:0097342

O15519 (UniProtKB)

IDA

GO:1901740

O15519 (UniProtKB)

ISS

GO:1902041

O15519 (UniProtKB)

TAS

GO:1902042

O15519 (UniProtKB)

IMP

GO:1902042

O15519 (UniProtKB)

TAS

GO:1902042

O15519 (UniProtKB)

TAS

GO:2001237

O15519 (UniProtKB)

IMP

GO:2001237

O15519 (UniProtKB)

IDA

microRNAs potentially regulating CFLAR:

hsa-miR-7 hsa-miR-512-3p hsa-miR-26a hsa-miR-346

String

BioGrid

IntAct

mentha

MINT

Reactome

Loading…

Interacting Gene	Interaction	Source/Score

KEGG
Reactomepathway

Name
4064 NF-kappa B signaling pathway [PATH:hsa04064]
4668 TNF signaling pathway [PATH:hsa04668]
4210 Apoptosis [PATH:hsa04210]
5142 Chagas disease (American trypanosomiasis) [PATH:hsa05142]

Name
Apoptosis
CASP8 activity is inhibited
Caspase activation via extrinsic apoptotic signalig pathway
Death Receptor Signalling
Dimerization of procaspase-8
Ligand-dependent caspase activation
Programmed Cell Death
Regulated Necrosis
Regulation by c-FLIP
Regulation of necroptotic cell death
RIPK1-mediated regulated necrosis
Signal Transduction
TRAIL signaling

Disease

Score

NofPmids

NofSnps

Source

Disease	Score	NofPmids	NofSnps	Source
Hodgkin Disease	0.126263026	4	0	BeFree_CTD_human_LHGDN
leukemia	0.1254487	3	0	CTD_human_LHGDN
MYELODYSPLASTIC SYNDROME	0.123267234	3	0	BeFree_CTD_human_LHGDN
Pancreatic Neoplasm	0.120271442	2	0	BeFree_CTD_human
Lymphoma, Extranodal NK-T-Cell	0.120271442	1	0	BeFree_CTD_human
Hyperoxia	0.08	1	0	RGD
Endometrial Neoplasms	0.008173051	3	0	LHGDN
Colorectal Neoplasms	0.008173051	3	0	LHGDN
Prostatic Neoplasms	0.008173051	3	0	LHGDN
Multiple Myeloma	0.005634266	4	0	BeFree_GAD_LHGDN

In-silico identification of genetic variants associated with chronic lymphocytic leukemia for diagnostic and therapeutic applications.

Islam MS, Mollah MMH, Ahsan MA, Ali M, Al Noman M, Ahmed MF, Latif MA, Pal NK, Faysal MF, Mollah MNH Sci Rep IF: 4.9 2026-03-23

Targeting RSF1 with tanshinone I inhibits cervical cancer cell growth through modulation of NF-κB pathway.

Shen Y, Lu S, Zhao Q, Cui T, Cui H, Cui Z, Shan L, Guo C, Shi L Front Pharmacol IF: 4.400 None

The Curcumin Analogue PAC Induces Selective Apoptosis-Related Transcriptomic Reprogramming in Oral Squamous Carcinoma Cells.

Benchekroun S, Hammache M, Chandad F, Almutairi MH, Daich A, Badwelan M, Rouabhia M, Semlali A Life (Basel) 2026-06-23

CRISPR screens identify PRMT7 as a therapeutic target to enhance T cell-mediated killing in breast cancer.

Shi W, Luo Y, Wang Y, Burrows JM, Black D, Civitarese A, Perlaza-Jimenez L, Zhang P, Manning M, Tuano N, Rentería ME, Xiao C, Tey SK, Rosenbluh J, Smith C, Chenevix-Trench G, Beesley J NPJ Breast Cancer 2026-01-21

Expression of cFLIP in B cells is essential for diffuse large B-cell lymphoma pathogenesis.

Bariboloka KT, Serrano-Saenz S, Savcigil DP, Spöck S, Poss RE, Schreurs LD, Löber J, Serin N, Valiulis J, Nugraha K, Gangarossa G, Lütz A, Reese M, Klein S, Enssle JC, Buettner R, Kashkar H, Peifer M, Chapuy B, Knittel G, Labi V, Villunger A, Nguyen PH, Scheich S, Oellerich T, Walczak H, Flümann R, Jachimowicz RD, Hallek M, Reinhardt HC, Annibaldi A Blood IF: 23.9 2026-08-20

Single-cell analysis reveals the prognostic role of immune escape in the colorectal cancer microenvironment.

Gan Q, Xu X, Liu H, Li Y Transl Cancer Res IF: 2.1 2026-01-31

Single-cell RNA-seq reveals the piperlongumine is a potential drug for ischemic stroke.

Li J, Zhu X, Zhang Y, Xu Z, Zhuang Y, Chen L, Cao Y, Chang C, Lv Y PLoS One IF: 2.6 None

Higher frequencies of CNV deletions in bipolar disorder among Chinese Population.

Wu Y, Li X, Sun Y, Zhang C, Sun P, Hui L, Zhao Y, Feng X, Wang B, Yang J, Zhang N, Yuan J, Jiang H, Cheng Y, Ma S, Gong Q, Yin X, Yang Y, Li W, Lv L, Zhou D, Li X, Chen X, Zhang C, Song X, Tang W, Liu Z, Shi Y, Xiao X, Yue W, Li Z, Li M Mol Psychiatry IF: 10.4 2026-08-27

MAFF mediates transcriptional activation of CFLAR to reduce regulatory T cell apoptosis and inhibit diabetic retinopathy progression.

Kang X, Li J, Cao Y Tissue Cell 2026-06-23

Physiological Effects of Dietary Protein and Its Optimal Requirement for Early Juvenile Chinese Tapertail Anchovy (Coilia nasus).

Zhang L, Chen X, Huang D, Zhou Q, Xu X, Ren M, Zhang L, Liang H Animals (Basel) IF: 3.2 2026-06-18

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CFLAR (CASP8 and FADD like apoptosis regulator)

Gene Basic Information

Gene Basic Information

Chromosome Location

Chromosome Location

Gene Summary

Gene Summary

Gene Sequence

Gene Sequence

Encoded Protein

Encoded Protein

Gene Variants

Gene Variants

Gene Expression

Gene Expression

Gene Primers

Gene Primers

Transcription Factors

Transcription Factors

Gene Ontology

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