DAXX基因详情-基因数据库-基因云馆

DAXX (death domain associated protein)

symbol:: DAXX
locus group:: protein-coding gene
location:: 6p21.32
gene_family:
alias symbol:: DAP6
alias name:: None
entrez id:: 1616
ensembl gene id:: ENSG00000204209
ucsc gene id:: uc011drd.3
refseq accession:: NM_001141969
hgnc_id:: HGNC:2681
approved reserved:: 1998-03-25

6p21.32

DAXX（Death Domain-Associated Protein 6）是一个重要的基因，编码的蛋白质主要参与细胞凋亡、染色质重塑和转录调控等生物学过程。DAXX蛋白最初被发现通过与Fas死亡结构域相互作用来调节细胞凋亡，后来研究发现它还作为组蛋白伴侣蛋白，参与组蛋白H3.3的沉积，影响染色质结构和基因表达调控。DAXX主要定位于细胞核，特别是在PML核小体中，与ATRX（Alpha Thalassemia/Mental Retardation Syndrome X-Linked）形成复合物，共同参与端粒维持和异染色质形成。DAXX的突变或功能异常与多种疾病相关，包括神经退行性疾病和癌症。例如，DAXX的失活突变在胰腺神经内分泌肿瘤中较为常见，可能导致基因组不稳定和肿瘤发生。DAXX过表达可能增强其凋亡抑制功能，促进细胞存活，但也可能干扰正常的染色质重塑过程，导致基因表达异常。相反，DAXX表达降低可能削弱组蛋白H3.3的沉积，影响染色质稳定性，并可能导致端粒功能障碍或基因组不稳定性增加。DAXX属于一个功能多样的基因家族，其成员通常参与细胞死亡调控和染色质动力学。该家族的共性包括含有死亡结构域或其它蛋白质相互作用模块，能够介导蛋白质-蛋白质相互作用，并在细胞应激反应、DNA损伤修复和表观遗传调控中发挥关键作用。DAXX的功能复杂性使其成为研究细胞命运决定和疾病机制的重要分子。

中文English

这个基因编码驻留在细胞核中的多个位置和在细胞质中的多功能蛋白质。它与多种蛋白，如细胞凋亡的抗原的Fas，着丝粒蛋白C，和转录因子红细胞增多病毒E26癌基因同系物1在核的相互作用，所编码的蛋白质的功能作为结合SUMO化转录因子的有力的转录阻抑物。它的镇压可以通过这种蛋白质螯合成髓细胞白血病核机构或核仁得到缓解。这种蛋白质也与关联G2期的着丝粒。在细胞质中，所编码的蛋白可以起到调节细胞凋亡。这种蛋白质的亚细胞定位和功能是由翻译后修饰，包括SUMO化，磷酸化和泛素化调制。选择性剪接结果在多个抄本变形。 [由RefSeq的，2008年11月提供]

OMIM数据库中对DAXX基因的介绍 Wikipedia数据库中对DAXX基因的介绍

DAXX基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MATANSIIVL DDDDEDEAAA QPGPSHPLPN AASPGAEAPS
41SSEPHGARGS SSSGGKKCYK LENEKLFEEF LELCKMQTAD
81
HPEVVPFLY NRQQRAHSLF LASAEFCNIL SRVLSRARSR
121PAKLYVYINE LCTVLKAHSA KKKLNLAPAA TTSNEPSGNN
161P
PTHLSLDP TNAENTASQS PRTRGSRRQI QRLEQLLALY
201VAEIRRLQEK ELDLSELDDP DSAYLQEARL KRKLIRLFGR
241LC
ELKDCSS LTGRVIEQRI PYRGTRYPEV NRRIERLINK
281PGPDTFPDYG DVLRAVEKAA ARHSLGLPRQ QLQLMAQDAF
321RDV
GIRLQE RRHLDLIYNF GCHLTDDYRP GVDPALSDPV
361LARRLRENRS LAMSRLDEVI SKYAMLQDKS EEGERKKRRA
401RLQG
TSSHS ADTPEASLDS GEGPSGMASQ GCPSASRAET
441DDEDDEESDE EEEEEEEEEE EEATDSEEEE DLEQMQEGQE
481DDEEE
DEEE EAAAGKDGDK SPMSSLQISN EKNLEPGKQI
521SRSSGEQQNK GRIVSPSLLS EEPLAPSSID AESNGEQPEE
561LTLEEE
SPV SQLFELEIEA LPLDTPSSVE TDISSSRKQS
601EEPFTTVLEN GAGMVSSTSF NGGVSPHNWG DSGPPCKKSR
641KEKKQTG
SG PLGNSYVERQ RSVHEKNGKK ICTLPSPPSP
681LASLAPVADS STRVDSPSHG LVTSSLCIPS PARLSQTPHS
721QPPRPGTC
K TSVATQCDPE EIIVLSDSD

结构预测来自 AlphaFold DB（UniProt: Q9UER7），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

DAXX基因的碱基突变：仅显示部分snp

rs11873 rs11873 rs11873 rs763122 rs763122 rs763122 rs1059231 rs1059231 rs1059231 rs2051625 rs2051625 rs2051625 rs2073524 rs2073524 rs2073524 rs2073525 rs2073525

DAXX基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

AGAGGAAGCAGTAGTTCGG

ACAAAGTTCAAGGAACTCTTCG

CTAAACACAACGAGCAGCC

TGAATGGTTCTTCTCCAGAGG

AGACGGTTTCTGAGTTCCT

GCCGGTTATAGAGGAATGG

ATCTGGAACAGATGCAGGA

CTCCATCTTTACCTGCTGC

GGTTTCTGAGCAGGAATTCTG

GCACGATGATGCTGTTAGC

CCTTCCTGTCCCTGAAAGG

ATTTCAGAATTCCTGCGCG

GGTTTCTGAGCAGGAATTCTG

CACGATGATGCTGTTAGCG

ATCTGGAACAGATGCAGGAG

CTCCATCTTTACCTGCTGCT

CTTCCTGTCCCTGAAAGGG

ATTTCAGAATTCCTGCGCG

GAGACGGTTTCTGAGTTCC

CCGGTTATAGAGGAATGGGA

转录因子

影响基因

影响类型

参考文献链接（PubMed）

DAXX

AIRE

Repression

20185822

DAXX基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

DAXX基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0005634

Q4VX54 (UniProtKB)

IDA

GO:0005737

Q4VX54 (UniProtKB)

IDA

GO:0000122

Q9UER7 (UniProtKB)

IEA

GO:0000775

Q9UER7 (UniProtKB)

IDA

GO:0001741

Q9UER7 (UniProtKB)

IEA

GO:0001934

Q9UER7 (UniProtKB)

IGI

GO:0002039

Q9UER7 (UniProtKB)

IPI

GO:0003714

Q9UER7 (UniProtKB)

IDA

GO:0005057

Q9UER7 (UniProtKB)

TAS

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005515

Q9UER7 (UniProtKB)

IPI

GO:0005634

Q9UER7 (UniProtKB)

IDA

GO:0005634

Q9UER7 (UniProtKB)

IMP

GO:0005634

Q9UER7 (UniProtKB)

IDA

GO:0005634

Q9UER7 (UniProtKB)

IDA

GO:0005634

Q9UER7 (UniProtKB)

IDA

GO:0005654

Q9UER7 (UniProtKB)

TAS

GO:0005654

Q9UER7 (UniProtKB)

TAS

GO:0005730

Q9UER7 (UniProtKB)

IEA

GO:0005737

Q9UER7 (UniProtKB)

IDA

GO:0005737

Q9UER7 (UniProtKB)

TAS

GO:0005829

Q9UER7 (UniProtKB)

ISS

GO:0005874

Q9UER7 (UniProtKB)

IEA

GO:0005938

Q9UER7 (UniProtKB)

IEA

GO:0006334

Q9UER7 (UniProtKB)

IDA

GO:0006334

Q9UER7 (UniProtKB)

IDA

GO:0006338

Q9UER7 (UniProtKB)

IDA

GO:0006351

Q9UER7 (UniProtKB)

IEA

GO:0006355

Q9UER7 (UniProtKB)

IDA

GO:0006915

Q9UER7 (UniProtKB)

TAS

GO:0007257

Q9UER7 (UniProtKB)

TAS

GO:0008134

Q9UER7 (UniProtKB)

IEA

GO:0008134

Q9UER7 (UniProtKB)

IDA

GO:0008625

Q9UER7 (UniProtKB)

TAS

GO:0010038

Q9UER7 (UniProtKB)

IEA

GO:0010832

Q9UER7 (UniProtKB)

IEA

GO:0016032

Q9UER7 (UniProtKB)

IEA

GO:0016605

Q9UER7 (UniProtKB)

IDA

GO:0016605

Q9UER7 (UniProtKB)

TAS

GO:0016605

Q9UER7 (UniProtKB)

IDA

GO:0019899

Q9UER7 (UniProtKB)

IPI

GO:0019901

Q9UER7 (UniProtKB)

IPI

GO:0030295

Q9UER7 (UniProtKB)

IGI

GO:0030521

Q9UER7 (UniProtKB)

IDA

GO:0030578

Q9UER7 (UniProtKB)

IEA

GO:0031072

Q9UER7 (UniProtKB)

TAS

GO:0031396

Q9UER7 (UniProtKB)

IDA

GO:0031625

Q9UER7 (UniProtKB)

IPI

GO:0033129

Q9UER7 (UniProtKB)

IEA

GO:0042393

Q9UER7 (UniProtKB)

IDA

GO:0042393

Q9UER7 (UniProtKB)

IDA

GO:0042803

Q9UER7 (UniProtKB)

IDA

GO:0043005

Q9UER7 (UniProtKB)

IEA

GO:0043065

Q9UER7 (UniProtKB)

IEA

GO:0044297

Q9UER7 (UniProtKB)

IEA

GO:0045860

Q9UER7 (UniProtKB)

IGI

GO:0045892

Q9UER7 (UniProtKB)

IDA

GO:0045892

Q9UER7 (UniProtKB)

IDA

GO:0045892

Q9UER7 (UniProtKB)

IDA

GO:0047485

Q9UER7 (UniProtKB)

IPI

GO:0047485

Q9UER7 (UniProtKB)

IPI

GO:0050681

Q9UER7 (UniProtKB)

IPI

GO:0070603

Q9UER7 (UniProtKB)

IDA

GO:0071356

Q9UER7 (UniProtKB)

IEA

GO:0071454

Q9UER7 (UniProtKB)

IEA

GO:1901216

Q9UER7 (UniProtKB)

IGI

可能调控 DAXX基因的相关microRNA：

hsa-miR-21 hsa-miR-222

String

BioGrid

IntAct

mentha

MINT

加载中…

关联基因	作用方式	资源库来源/分值

KEGG

名称
4010 MAPK signaling pathway [PATH:hsa04010]
5014 Amyotrophic lateral sclerosis (ALS) [PATH:hsa05014]
5168 Herpes simplex infection [PATH:hsa05168]

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Neuroendocrine Tumors	0.120542884	3	0	BeFree_CTD_human
Pancreatic Neoplasm	0.120271442	2	0	BeFree_CTD_human
Adrenocortical carcinoma	0.12	1	0	CTD_human
Hypoxia-Ischemia, Brain	0.08	1	0	RGD
Transient Ischemic Attack	0.08	1	0	RGD
Toxic effect of heavy metal	0.08	1	0	RGD
Infection	0.010897401	4	0	LHGDN
leukemia	0.010897401	4	0	LHGDN
Dengue Fever	0.00272435	1	0	LHGDN
Diabetes Mellitus, Insulin-Dependent	0.002638474	1	0	BeFree_GAD

DAXX promotes SUMOylation of chromatin-trapped DNMT1.

Tanimoto S, Wang TW, Yabushita T, Chiba Y, Konishi C, Endo A, Saeki Y, Goyama S, Nakanishi M, Nishiyama A J Biochem IF: 2.4 2026-05-11

SFPQ directs histone H3.3 deposition to R-loops in DNA repeats to protect genome stability.

Ferrando A, Giaquinto M, Napolitano LMR, Canarutto G, Framarini A, Gambelli A, Veneziano Broccia P, Zappone A, Petti E, Boncristiani C, Parlante A, Onesti S, Piazza S, Benetti R, Schoeftner S Nat Commun IF: 12.124 2026-02-24

Case Report: Identification of rare H3-3A p.G35W variant in a case of adolescent tectal plate low-grade glioma.

Ung A, Tomatis VM, Quick E, Satgunaseelan L, Knight E, Tsimiklis C, Page EC, Hansford JR, Mascarenhas AR Front Oncol IF: 3.4 None

Expression of ATRX, DAXX, PDX1, ARX, and somatostatin receptors in pancreatic neuroendocrine tumors: a clinicopathological study.

Ciobanu OA, Martin CS, Fica S, Herlea V, Tudose I, Vasilescu F, Sandra I, Barbu CG Front Endocrinol (Lausanne) IF: 5.7 None

Local heterochromatin enrichment promotes telomere clustering and PML nuclear body assembly at telomeres.

Taylor ER, Proctor B, Vaurs M, Wu G, Mahieu M, Shrestha S, Morrison D, Weatherly L, Brelinsky S, Raghunandan M, Decottignies A, Arnoult N Cell Rep IF: 6.9 2026-03-24

Time-resolved mapping in calves reveals bovine herpesvirus 1 shift from mucosal replication to trigeminal ganglion neuroinvasion with promyelocytic leukemia protein-centered host-virus antagonism.

Wang Y, Jin H, Wang F, Cheng J, Cao M, Zhou L, Liu W, Li Y Microbiol Spectr IF: 3.7 2026-07-23

A Rare Case of Pancreatic Neuroendocrine Tumor with Intraductal Extension in the Dorsal Duct of a Pancreas Divisum.

Crucillà S, Berlato A, Crinò SF, Landoni L, Conti Bellocchi MC Reports (MDPI) IF: 0.5 2026-03-28

DAXX governs the silencing of LINE1 during spermatogenesis in mice.

Li Z, Xiong C, Shen J, Tan C, Ma D, Chen J, Liu R, Sun Q, Gong W, Yuan W, Huang M, Huang L, Tan Y, Li G, Luo M Nucleic Acids Res IF: 15.0 2026-02-24

Automated Radiomics Model for Preoperative Pancreatic Neuroendocrine Tumor Grade Prediction.

Chandra P, Ghahremannezhad H, Nasar N, Gonen M, Do RKG, Sigel C, Pulvirenti A, Soares K, Balachandran V, Drebin J, D'Angelica M, Kingham TP, Jarnagin WR, Chakraborty J, Wei AC Ann Surg Oncol IF: 3.8 2026-08-00

Case Report: triple therapy with pembrolizumab, ipilimumab, and lenvatinib in mitotane- and radiation-refractory, cortisol-secreting stage IV adrenocortical carcinoma: a genomically guided approach.

Nakhleh A, Mahamid A, Yechiel Y, Saiegh L, Zolotov S, Stemmer SM Front Immunol IF: 7.0 None

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DAXX (death domain associated protein)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因相关评论

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联系地址

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