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Non-canonical histone H3.3 and its chaperones HIRA and DAXX participate in th...

McMahon(S),Jain(V),Morozov(V),Sethuraman(S... bioRxiv 2026-04-07

...DAXX. The interaction between LANA and these interphase active chaperones suggests that H3.3 deposition is a critical dr...

The ATRXt Protein Represses rDNA Transcription While Mirroring ATRX Interacti...

Levesque(MG),Picketts(DJ) Int J Mol Sci 2026-03-29

...DAXX and HP1α. Exon 10a can target a GFP-fusion protein to the nucleolus, but removal of exon 10a from ATRXt does not pr...

Distinct DAXX effector modules separate H3.3 nucleosome assembly from ERV sil...

Jain(AY),Hoelper(D),Rashoff(AQ),Lewis(PW) bioRxiv 2026-03-23

...DAXX-bound ERVs in cells. Despite failure to deposit H3.3, DAXX with substitutions in this basic patch retains localizat...

DAXX in Metabolic, Aging, and Immune Regulation: Recent Insights.

Zhou(J),Zhao(L),Tuo(Q) Cells 2026-02-27

Death domain-associated protein 6 (DAXX) was originally identified as a key regulator of Fas receptor-mediated apoptosis...

Building a diagnostic scoring system for high-grade neuroendocrine neoplasms ...

Kinowaki(Y),Wang(C),Fukumura(Y),Ganci(M),Z... Am J Clin Pathol 2026-03-03

...DAXX/ATRX loss (-1), and somatostatin receptor subtype 2A 3+ (-1). In validation, the average score for PanNEC was 9.52 ...

Local heterochromatin enrichment promotes telomere clustering and PML nuclear...

Taylor(ER),Proctor(B),Vaurs(M),Wu(G),Mahie... Cell Rep 2026-03-24

...DAXX), factors frequently mutated in ALT+ tumors. Together, these findings establish telomeric heterochromatin as a driv...

Expression of ATRX, DAXX, PDX1, ARX, and somatostatin receptors in pancreatic...

Ciobanu(OA),Martin(CS),Fica(S),Herlea(V),T... Front Endocrinol (Lausanne) None

...DAXX mutations with 96.9% sensitivity and 75% specificity (AUC 0.922, p = 0.007), in a cohort of 36 patients. ATRX/DAXX ...

Multi-omic profiles of neuroendocrine neoplasms of the pancreas: an integrate...

Bevere(M),Gkountakos(A),Valentinuzzi(S),De... Mol Cancer 2026-05-29

...DAXX/ATRX mutations, activation of the alternative lengthening of telomeres pathway, BEND2 gene fusions, and an α-cell t...

Somatic Genetic Alterations in Pituitary Neuroendocrine Tumors.

Schwarz(Y),Halperin(R),Tirosh(A) Endocr Relat Cancer 2026-08-07

...DAXX, are enriched in aggressive corticotroph tumors. Identification of new molecular markers and delineation of their c...

Microglia activation by derepression of endogenous retroviruses drives inflam...

Yan(X),Georgopoulou(C),Lee(HM),Ahrari(A),R... Nat Neurosci 2026-08-17

...DAXX, a histone chaperone and RTE repressor, is downregulated during aging, preserves microglia homeostasis and inhibits...

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