FGR (FGR proto-oncogene, Src family tyrosine kinase)

基因基本信息

基因基本信息

symbol:
FGR
locus group:
protein-coding gene
location:
1p35.3
gene_family:
SH2 domain containing
alias symbol:
c-fgr|p55c-fgr
alias name:
None
entrez id:
2268
ensembl gene id:
ENSG00000000938
ucsc gene id:
uc001bom.4
refseq accession:
NM_005248
hgnc_id:
HGNC:3697
approved reserved:
2001-06-22

基因染色体位置

基因染色体位置

1p35.3

基因简述

基因简述

FGR基因（也称为FGR原癌基因或SRC2）属于SRC家族酪氨酸激酶基因家族，该家族成员在细胞信号传导中起关键作用，参与调控细胞生长、分化、迁移和存活等过程。FGR编码一种非受体型酪氨酸激酶，主要表达于造血细胞（如B细胞、巨噬细胞和中性粒细胞）中，通过磷酸化下游靶蛋白传递信号。FGR蛋白包含SH3、SH2和激酶结构域，能与其他信号分子相互作用形成复合物。FGR的功能异常与多种疾病相关，其过度激活可能导致炎症反应增强和自身免疫疾病，而功能丧失则可能影响免疫细胞功能。研究发现FGR在某些白血病（如慢性淋巴细胞白血病）中表达升高，可能促进癌细胞存活和增殖。FGR基因突变可能破坏其激酶活性或蛋白相互作用能力，导致信号传导异常。在动物模型中，FGR敲除小鼠表现出免疫系统轻微缺陷但对大多数生理功能无严重影响，说明该基因功能可能存在冗余。SRC家族基因（包括SRC、YES、LYN等）的共性是都能通过酪氨酸磷酸化调控下游信号通路，许多成员在癌症中异常激活。FGR过表达可能增强炎症反应并促进某些肿瘤发展，而表达降低可能削弱免疫细胞功能但通常不会引起严重表型。该基因与炎症性疾病和血液系统恶性肿瘤的关联使其成为潜在的治疗靶点，针对SRC家族激酶的抑制剂（如达沙替尼）已用于临床但缺乏对FGR的特异性。

中文English

无

OMIM数据库中对FGR基因的介绍     Wikipedia数据库中对FGR基因的介绍

基因序列

基因序列

FGR基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MGCVFCKKLE PVATAKEDAG LEGDFRSYGA ADHYGPDPTK
41ARPASSFAHI PNYSNFSSQA INPGFLDSGT IRGVSGIGVT
81 LFIALYDYE ARTEDDLTFT KGEKFHILNN TEGDWWEARS
121LSSGKTGCIP SNYVAPVDSI QAEEWYFGKI GRKDAERQLL
161S PGNPQGAF LIRESETTKG AYSLSIRDWD QTRGDHVKHY
201KIRKLDMGGY YITTRVQFNS VQELVQHYME VNDGLCNLLI
241AP CTIMKPQ TLGLAKDAWE ISRSSITLER RLGTGCFGDV
281WLGTWNGSTK VAVKTLKPGT MSPKAFLEEA QVMKLLRHDK
321LVQ LYAVVS EEPIYIVTEF MCHGSLLDFL KNPEGQDLRL
361PQLVDMAAQV AEGMAYMERM NYIHRDLRAA NILVGERLAC
401KIAD FGLAR LIKDDEYNPC QGSKFPIKWT APEAALFGRF
441TIKSDVWSFG ILLTELITKG RIPYPGMNKR EVLEQVEQGY
481HMPCP PGCP ASLYEAMEQT WRLDPEERPT FEYLQSFLED
521YFTSAEPQYQ PGDQT
结构预测来自 AlphaFold DB（UniProt: P09769），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

FGR基因的碱基突变：           仅显示部分snp
rs761069       rs878648       rs1292073       rs1292087       rs1292088       rs1292089       rs1890462       rs1890463       rs2231863       rs2231864       rs2231865       rs2231866       rs2231867       rs2231868       rs2231869       rs2231870       rs2231871      

基因表达

基因表达

FGR基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
GGTCCTTTCTCTGGTATGGG
60
CGGCTCCAATTTCTTGCAG
60
CATCAAGTCAGACGTGTGG
59
TATTCATGCCTGGGTAGGG
59
CATCAAGTCAGACGTGTGG
59
TATTCATGCCTGGGTAGGG
59
ACTATGAGGCTCGAACTGAG
59
AGTCACCTTCAGTATTGTTCAG
58
CATCAAGTCAGACGTGTGG
59
TATTCATGCCTGGGTAGGG
59
CCGCTTTCAAGATCACATGG
60
ACTGTGGTTTCTGATGGGA
59
ACTATGAGGCTCGAACTGAG
59
AGTCACCTTCAGTATTGTTCAG
58
CATCAAGTCAGACGTGTGG
59
TATTCATGCCTGGGTAGGG
59
TCAAGTCAGACGTGTGGTC
60
TTATTCATGCCTGGGTAGGG
59
TCAAGTCAGACGTGTGGTC
60
TTATTCATGCCTGGGTAGGG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

FGR基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

FGR基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0001784
P09769 (UniProtKB)
ISS
GO:0002768
P09769 (UniProtKB)
TAS
GO:0004713
P09769 (UniProtKB)
EXP
GO:0004713
P09769 (UniProtKB)
EXP
GO:0004713
P09769 (UniProtKB)
IDA
GO:0004713
P09769 (UniProtKB)
TAS
GO:0004715
P09769 (UniProtKB)
IDA
GO:0004715
P09769 (UniProtKB)
TAS
GO:0005515
P09769 (UniProtKB)
IPI
GO:0005515
P09769 (UniProtKB)
IPI
GO:0005515
P09769 (UniProtKB)
IPI
GO:0005515
P09769 (UniProtKB)
IPI
GO:0005515
P09769 (UniProtKB)
IPI
GO:0005515
P09769 (UniProtKB)
IPI
GO:0005515
P09769 (UniProtKB)
IPI
GO:0005524
P09769 (UniProtKB)
IEA
GO:0005743
P09769 (UniProtKB)
IEA
GO:0005758
P09769 (UniProtKB)
IEA
GO:0005829
P09769 (UniProtKB)
TAS
GO:0005829
P09769 (UniProtKB)
TAS
GO:0005829
P09769 (UniProtKB)
TAS
GO:0005886
P09769 (UniProtKB)
ISS
GO:0006468
P09769 (UniProtKB)
TAS
GO:0007169
P09769 (UniProtKB)
IBA
GO:0007229
P09769 (UniProtKB)
ISS
GO:0007229
P09769 (UniProtKB)
IMP
GO:0007229
P09769 (UniProtKB)
IMP
GO:0008360
P09769 (UniProtKB)
ISS
GO:0009615
P09769 (UniProtKB)
TAS
GO:0014068
P09769 (UniProtKB)
IMP
GO:0016477
P09769 (UniProtKB)
IBA
GO:0018108
P09769 (UniProtKB)
IDA
GO:0018108
P09769 (UniProtKB)
IDA
GO:0019901
P09769 (UniProtKB)
ISS
GO:0030154
P09769 (UniProtKB)
IBA
GO:0030335
P09769 (UniProtKB)
ISS
GO:0031234
P09769 (UniProtKB)
IBA
GO:0034987
P09769 (UniProtKB)
ISS
GO:0034988
P09769 (UniProtKB)
IDA
GO:0038083
P09769 (UniProtKB)
IBA
GO:0038096
P09769 (UniProtKB)
TAS
GO:0042127
P09769 (UniProtKB)
IBA
GO:0043306
P09769 (UniProtKB)
ISS
GO:0043552
P09769 (UniProtKB)
IMP
GO:0045087
P09769 (UniProtKB)
IBA
GO:0045088
P09769 (UniProtKB)
ISS
GO:0045859
P09769 (UniProtKB)
ISS
GO:0046777
P09769 (UniProtKB)
IDA
GO:0046777
P09769 (UniProtKB)
IDA
GO:0050715
P09769 (UniProtKB)
ISS
GO:0050764
P09769 (UniProtKB)
ISS
GO:0050830
P09769 (UniProtKB)
ISS
GO:0070062
P09769 (UniProtKB)
IDA
GO:0070062
P09769 (UniProtKB)
IDA
GO:0005856
P09769 (UniProtKB)
IDA
GO:0015629
P09769 (UniProtKB)
ISS
GO:0032587
P09769 (UniProtKB)
ISS
GO:0004715
Q5TGY6 (UniProtKB)
IEA
GO:0005524
Q5TGY6 (UniProtKB)
IEA
GO:0018108
Q5TGY6 (UniProtKB)
IEA
GO:0018108
Q5TGY6 (UniProtKB)
IEA
GO:0045087
Q5TGY6 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 FGR基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String
BioGrid
IntAct
mentha
MINT
Reactome
加载中…
关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
HIV Infections 0.002638474 2 0 BeFree_GAD
Breast Carcinoma 0.000542884 2 0 BeFree
Malignant neoplasm of breast 0.000542884 2 0 BeFree
early pregnancy 0.000271442 1 0 BeFree
Diabetes Mellitus, Insulin-Dependent 0.000271442 1 0 BeFree
Liver carcinoma 0.000271442 1 0 BeFree
Leukemia, Myelocytic, Acute 0.000271442 1 0 BeFree
Female Genital Diseases 0.000271442 1 0 BeFree
Tumor Progression 0.000271442 1 0 BeFree
Gestational Diabetes 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

GAL and F2R as immune diagnostic biomarkers for fetal growth restriction.
Chen S, Ke Y, Zhou Z, Xie Y, Chen W, Huang L, Sheng L, Wang Y, Chen B, Yang C, Wu Z iScience 2026-04-17
Association of Fetal Growth Retardation with Postnatal Osteoprotegerin Concentrations and Aortic Intima-Media Thickness.
Karatza AA, Kostopoulou E, Fouzas S, Antonakopoulos N, Sinopidis X, Kritikou D, Efthymiadou A, Dimitriou G, Chrysis D Diseases 2026-03-08
The Impact of Fetal Growth Restriction on Myocardial Development from Fetal Life to Early Childhood: A Narrative Review.
Mannarino S, Calcaterra V, Garella V, Puricelli F, Baj B, Quatrale A, Gazzola C, Nosvelli A, Raso I, Zuccotti G Children (Basel) 2026-02-24
Prenatal Classification and Perinatal Outcomes of Fetal Umbilical-Portal-Systemic Venous Shunts: A Tertiary Center Experience.
Kurt Bilirer K, Özer Caltek H, Arslanoğlu T, Ersan F, Erenel H Diagnostics (Basel) 2026-03-11
Placental insufficiency markers to assess the risk of non-chromosomal genetic conditions in early-onset fetal growth restriction.
Armengol-Alsina M, Bonacina E, Dalmau M, Temprado J, Valenzuela I, Codina-Solà M, Viñas-Jornet M, Rodó C, Mendoza M, Collaborators Ultrasound Obstet Gynecol IF: 5.3 2026-04-00
Whole-exome sequencing increases variant detection compared to karyotyping and CMA in an unselected FGR cohort.
Liu J, Lin K, Mai Z, Zhang Y, Li X, Meng X, Chen H Sci Rep IF: 4.9 2026-04-14
Antenatal Detection Rate of Foetal Growth Restriction in Primary Healthcare Centres: A Service Evaluation From Dammam, Saudi Arabia.
Al-Blowi H, AlKhathami AD, Meriki N, Altherman TM, Almalki FG, Alqahtani AM, Alghamdi HM, Al-Ajmi A, Almarzooq AY Cureus 2026-03-00
Plasma proteome is altered in a piglet model of fetal growth restriction.
Musco H, Lee A, Chand KK, Colditz PB, Wixey JA Sci Rep IF: 4.9 2026-04-15

基因相关服务

基因相关服务

基因相关评论

基因相关评论

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