GOT2 (glutamic-oxaloacetic transaminase 2)

Gene Basic Information

Gene Basic Information

symbol
GOT2
locus group
protein-coding gene
location
16q21
gene_family
-
alias symbol
mitAAT|KATIV|KAT4|KYAT4
alias name
kynurenine aminotransferase IV|asp…
entrez id
2806
ensembl gene id
ENSG00000125166
ucsc gene id
uc002eof.2
refseq accession
NM_002080
hgnc_id
HGNC:4433
approved reserved
2001-06-22

Chromosome Location

Chromosome Location

16q21

Gene Summary

Gene Summary

ChineseEnglish

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

OMIM entry for GOT2     Wikipedia entry for GOT2

Gene Sequence

Gene Sequence

Nucleotide sequence of GOT2:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MALLHSGRVL PGIAAAFHPG LAAAASARAS SWWTHVEMGP
41PDPILGVTEA FKRDTNSKKM NLGVGAYRDD NGKPYVLPSV
81 RKAEAQIAA KNLDKEYLPI GGLAEFCKAS AELALGENSE
121VLKSGRFVTV QTISGTGALR IGASFLQRFF KFSRDVFLPK
161P TWGNHTPI FRDAGMQLQG YRYYDPKTCG FDFTGAVEDI
201SKIPEQSVLL LHACAHNPTG VDPRPEQWKE IATVVKKRNL
241FA FFDMAYQ GFASGDGDKD AWAVRHFIEQ GINVCLCQSY
281AKNMGLYGER VGAFTMVCKD ADEAKRVESQ LKILIRPMYS
321NPP LNGARI AAAILNTPDL RKQWLQEVKV MADRIIGMRT
361QLVSNLKKEG STHNWQHITD QIGMFCFTGL KPEQVERLIK
401EFSI YMTKD GRISVAGVTS SNVGYLAHAI HQVTK
Structure predicted by AlphaFold DB(UniProt: P00505). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of GOT2:           Showing partial SNPs
rs6993       rs14221       rs30834       rs30835       rs30836       rs30837       rs30838       rs30839       rs30840       rs30841       rs30842       rs30843       rs40574       rs40575       rs171786       rs173992       rs183757      

Gene Expression

Gene Expression

Tissue expression of GOT2:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TTACGTTCTGCCTAGCGTC
59
TGGGCAGGTATTCCTTGTC
59
AGGCATCTGCAGAACTAGC
59
GTCTGCACAGTGACAAACC
59
CTTATATGGTGAGCGTGTAGGA
59
CTTCAACTGTGACTCTACCCT
59
ACAATGGCTGCAAGAAGTG
59
TTGGAGACCAGTTGAGTCC
59
CAACAGTGGTGAAGGTGAG
58
CTTCAACTGTGACTCTACCCT
59
AGGAATACCTGCCCATTGG
59
CTGCACAGTGACAAACTGG
59
AGGCATCTGCAGAACTAGC
59
GTCTGCACAGTGACAAACTG
59
CTTACGTTCTGCCTAGCGT
59
GGCAGGTATTCCTTGTCCA
59
CATCTGCAGAACTAGCCCT
59
GTCTGCACAGTGACAAACC
59
GGCTGCAAGAAGTGAAAGTC
59
AGGTTGGAGACCAGTTGAG
59

Gene Ontology

Subcellular localization of GOT2 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for GOT2:

GO ID
Protein
Source DB
GO:0004069
P00505 (UniProtKB)
ISS
GO:0004069
P00505 (UniProtKB)
IDA
GO:0004069
P00505 (UniProtKB)
IDA
GO:0004069
P00505 (UniProtKB)
IDA
GO:0004069
P00505 (UniProtKB)
EXP
GO:0005543
P00505 (UniProtKB)
IEA
GO:0005739
P00505 (UniProtKB)
ISS
GO:0005739
P00505 (UniProtKB)
IDA
GO:0005739
P00505 (UniProtKB)
IDA
GO:0005743
P00505 (UniProtKB)
IEA
GO:0005743
P00505 (UniProtKB)
IEA
GO:0005759
P00505 (UniProtKB)
TAS
GO:0005759
P00505 (UniProtKB)
TAS
GO:0005886
P00505 (UniProtKB)
IDA
GO:0006094
P00505 (UniProtKB)
TAS
GO:0006103
P00505 (UniProtKB)
ISS
GO:0006107
P00505 (UniProtKB)
IEA
GO:0006531
P00505 (UniProtKB)
ISS
GO:0006532
P00505 (UniProtKB)
IEA
GO:0006533
P00505 (UniProtKB)
IDA
GO:0006536
P00505 (UniProtKB)
ISS
GO:0008652
P00505 (UniProtKB)
TAS
GO:0009986
P00505 (UniProtKB)
IEA
GO:0015908
P00505 (UniProtKB)
IEP
GO:0016212
P00505 (UniProtKB)
IEA
GO:0016597
P00505 (UniProtKB)
IEA
GO:0019470
P00505 (UniProtKB)
TAS
GO:0019550
P00505 (UniProtKB)
IEA
GO:0019551
P00505 (UniProtKB)
IEA
GO:0019899
P00505 (UniProtKB)
IEA
GO:0030170
P00505 (UniProtKB)
IBA
GO:0042802
P00505 (UniProtKB)
IBA
GO:0042803
P00505 (UniProtKB)
IEA
GO:0043204
P00505 (UniProtKB)
IEA
GO:0043209
P00505 (UniProtKB)
IEA
GO:0043234
P00505 (UniProtKB)
IEA
GO:0044822
P00505 (UniProtKB)
IDA
GO:0045471
P00505 (UniProtKB)
IDA
GO:0070062
P00505 (UniProtKB)
IDA
GO:0070062
P00505 (UniProtKB)
IDA
GO:0070062
P00505 (UniProtKB)
IDA
GO:0080130
P00505 (UniProtKB)
IEA
GO:0097052
P00505 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating GOT2:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Obesity 0.002714419 10 2 BeFree
Diabetes Mellitus, Non-Insulin-Dependent 0.002442977 9 2 BeFree
Arteriosclerosis 0.001085767 4 0 BeFree
Malignant Glioma 0.001085767 4 0 BeFree
Diabetes Mellitus 0.001085767 4 0 BeFree
Cardiovascular Diseases 0.001085767 4 0 BeFree
Anaplastic thyroid carcinoma 0.001085767 4 0 BeFree
Atherosclerosis 0.001085767 4 0 BeFree
Metabolic Syndrome X 0.000814326 3 0 BeFree
Thyroid carcinoma 0.000814326 3 0 BeFree

Related Publications

Related Publications

Redox imbalance dictates dependence on GOT1 versus GOT2 for rod photoreceptor health during aging and stress.
Chen M, Weh E, Goswami MT, Weh KM, Hager H, Sajjakulnukit P, Weingarten A, Subramanya S, Miller N, Chaudhury S, Piraino E, Chandel NS, Ryals RC, Lyssiotis CA, Wubben TJ bioRxiv 2026-04-07
Transcriptomic and metabolomic insights into high-temperature acclimation mechanisms of Anoectochilus roxburghii.
Zhang S, Li H, Zou H, Li H, Lin J, Dai Y Funct Plant Biol IF: 2.9 2026-04-24
Transsulfuration links aspartate-asparagine metabolism and redox homeo-stasis to drive tumor growth.
Milosevic M, Dmytruk K, Alghadi A, Jakoube P, Wong Soon J, Hyrossova P, Bin Munim M, Fernandes SI, Shevzov-Zebrun A, Stanko R, Mitric I, Cockova Z, Kucera L, Fernández-García J, Benda A, Marzullo B, Sedlacek R, Neuzil J, Fendt SM, Tennant DA, Vander Heiden MG, Rohlenova K, Rohlena J bioRxiv 2026-07-13
Integrated molecular mechanisms of salinity response in Apostichopus japonicus: focus on miRNA-driven core pathways and target gene regulation.
Chen J, Zhao Y, Li N, Wang H, Wu X, Wang B, Wei X, Chang Y, Tian Y Mar Biotechnol (NY) IF: 2.8 2026-08-10
Comparative transcriptome analysis of kiwifruit reveals candidate genes involved in soft rot resistance against Botryosphaeria dothidea.
Lv D, Li Y, Zuo X, Yang J, Tu G, Wang J, Cai Z, Shen Y, Du H, Zhang W, Zhu L J Sci Food Agric IF: 4.0 2026-05-00
TRIM24 Regulates Adaptation to Glucose Deprivation in Association with Aspartate Accumulation and Impaired AMPK Signaling.
Yu X, An D, Ren D, He P, Yang Y, Chen N, Wang R, Wu S, Feng J, Feng M Curr Issues Mol Biol IF: 4.1 2026-04-14
Glioblastoma cells utilize evolutionarily adapted cell metabolism to promote their malignant proliferation.
Bespalov MM, Gkini V, Iloglu Z, Yamada S, Nemoto A, Filppu P, Trontti K, Andriichuk L, Pietiläinen O, Le Joncour V, Nieminen AI, Laakkonen P, Namba T Acta Neuropathol Commun IF: 6.5 2026-05-13
A shift in the cellular redox state redirects aspartate for export under glucose deprivation.
Konrad B, Bluemel G, Haitzmann T, Frech T, Vandekeere A, Planque M, Bubalo V, Schindlmaier K, Jäger V, Dengler MA, Stryeck S, Brcic L, Lindenmann J, Stiegler P, Bresilla D, Madreiter-Sokolowski CT, Madl T, Eichmann TO, Kneidinger N, Fendt SM, Leithner K Cancer Metab 2026-03-03
Circadian tryptophan metabolism contributes to systemic aryl hydrocarbon receptor activity.
Morgan EW, Murray IA, Coslo DM, Patterson AD, Perdew GH iScience 2026-02-20

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