HLX (H2.0 like homeobox)

Gene Basic Information

Gene Basic Information

symbol
HLX
locus group
protein-coding gene
location
1q41
gene_family
NKL subclass homeoboxes and pseudogenes
alias symbol
HB24
alias name
None
entrez id
3142
ensembl gene id
ENSG00000136630
ucsc gene id
uc001hmv.5
refseq accession
NM_021958
hgnc_id
HGNC:4978
approved reserved
1992-04-02

Chromosome Location

Chromosome Location

1q41

Gene Summary

Gene Summary

HLX（也称为HB24或HLX1）是一个属于同源盒（homeobox）基因家族的成员，该家族以保守的DNA结合域（同源域）为特征，参与调控胚胎发育、细胞分化和组织形态发生。HLX基因位于人类染色体1q41-q42区域，编码一个转录因子，主要在造血系统、肝脏和肠道发育过程中表达。HLX通过调控下游靶基因的转录，影响细胞增殖、迁移和分化，尤其在造血干细胞和淋巴细胞的发育中起关键作用。HLX的表达异常与多种疾病相关，例如其过表达可能促进某些白血病（如急性髓系白血病）的发生，因为它可能干扰正常造血分化程序，导致未成熟细胞的异常增殖。相反，HLX表达降低可能影响肠道和肝脏的发育，导致组织功能障碍。在小鼠模型中，HLX缺失会导致胚胎死亡或严重的造血和肝脏发育缺陷，表明其对早期发育至关重要。HLX还参与免疫调节，其表达水平变化可能影响T细胞和B细胞的功能，进而与自身免疫疾病或免疫缺陷相关。HLX属于同源盒基因家族中的NK-like亚家族，该家族成员通常在中胚层和神经外胚层发育中发挥作用，具有保守的DNA结合能力，并通过调控细胞命运决定基因的表达影响发育过程。HLX的功能研究为理解发育异常和肿瘤发生提供了重要线索，其作为潜在的治疗靶点正在被探索。

OMIM entry for HLX     Wikipedia entry for HLX

Gene Sequence

Gene Sequence

Nucleotide sequence of HLX:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MFAAGLAPFY ASNFSLWSAA YCSSAGPGGC SFPLDPAAVK
41KPSFCIADIL HAGVGDLGAA PEGLAGASAA ALTAHLGSVH
81 PHASFQAAA RSPLRPTPVV APSEVPAGFP QRLSPLSAAY
121HHHHPQQQQQ QQQPQQQQPP PPPRAGALQP PASGTRVVPN
161P HHSGSAPA PSSKDLKFGI DRILSAEFDP KVKEGNTLRD
201LTSLLTGGRP AGVHLSGLQP SAGQFFASLD PINEASAILS
241PL NSNPRNS VQHQFQDTFP GPYAVLTKDT MPQTYKRKRS
281WSRAVFSNLQ RKGLEKRFEI QKYVTKPDRK QLAAMLGLTD
321AQV KVWFQN RRMKWRHSKE AQAQKDKDKE AGEKPSGGAP
361AADGEQDERS PSRSEGEAES ESSDSESLDM APSDTERTEG
401SERS LHQTT VIKAPVTGAL ITASSAGSGG SSGGGGNSFS
441FSSASSLSSS STSAGCASSL GGGGASELLP ATQPTASSAP
481KSPEP AQGA LGCL
Structure predicted by AlphaFold DB(UniProt: Q14774). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of HLX:           Showing partial SNPs
rs949994       rs2184658       rs2247213       rs2484692       rs2738751       rs2738752       rs2738754       rs2807857       rs3806324       rs3806325       rs3820355       rs3840440       rs11300127       rs12041280       rs12096405       rs12141189       rs12730158      

Gene Expression

Gene Expression

Tissue expression of HLX:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GTTTCCAGGTCCCTATGCT
59
TTTCTCCAGGCCTTTCCTC
59
GACCTCAAACACTTGTGCT
58
TTATTCCCGCATGTGTCCA
59
TCCCATTAACGAGGCTTCTG
59
AACTGAATTTCTTGGGTTCGAG
59
GTTTCCAGGTCCCTATGCT
59
CTTTCCTCTGCAGGTTGGA
59
GTTTCCAGGTCCCTATGCT
59
TTTCCTCTGCAGGTTGGAG
59
TCTGCTTCCCATGTTTCCT
59
CTCCTCTACTGCCACTACC
58

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
HLX
BTG1
Unknown
22897850
HLX
PAK1
Unknown
22897850
POU5F1
HLX
Repression
17068183

Gene Ontology

Subcellular localization of HLX (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for HLX:

GO ID
Protein
Source DB
GO:0005634
F8VWZ5 (UniProtKB)
IEA
GO:0006355
F8VWZ5 (UniProtKB)
IEA
GO:0043565
F8VWZ5 (UniProtKB)
IEA
GO:0001889
Q14774 (UniProtKB)
IEA
GO:0005515
Q14774 (UniProtKB)
IPI
GO:0005634
Q14774 (UniProtKB)
IEA
GO:0006351
Q14774 (UniProtKB)
IEA
GO:0006355
Q14774 (UniProtKB)
IEA
GO:0007275
Q14774 (UniProtKB)
TAS
GO:0007519
Q14774 (UniProtKB)
IEA
GO:0008284
Q14774 (UniProtKB)
IEA
GO:0030154
Q14774 (UniProtKB)
IEA
GO:0043565
Q14774 (UniProtKB)
IDA
GO:0045627
Q14774 (UniProtKB)
IEA
GO:0045629
Q14774 (UniProtKB)
IEA
GO:0046622
Q14774 (UniProtKB)
IEA
GO:0048484
Q14774 (UniProtKB)
IEA
GO:0048557
Q14774 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating HLX:     

Gene Interactions

Gene Interactions

String
BioGrid
mentha
MINT
Loading…
Interacting Gene Interaction Source/Score

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Asthma 0.008001298 3 0 BeFree_GAD_LHGDN
Systemic arterial pressure 0.002367032 1 1 GAD
Myeloid Leukemia 0.002367032 1 0 GAD
Blood pressure finding 0.002367032 1 1 GAD
Dupuytren Contracture 0.002367032 1 1 GAD
Leukemia, Myelocytic, Acute 0.001085767 4 0 BeFree
Leukemogenesis 0.000814326 3 0 BeFree
Childhood asthma 0.000542884 2 0 BeFree
Acute leukemia 0.000271442 1 0 BeFree
Congenital diaphragmatic hernia 0.000271442 1 0 BeFree

Related Publications

Related Publications

LncRNA-HLX-2-7/HLX axis-dependent metabolic reprogramming drives cancer progression in group 3 medulloblastoma.
Katsushima K, Sanada Y, Scott DA, Stapleton S, Jallo G, Eberhart CG, Perera RJ Acta Neuropathol Commun IF: 6.5 2026-03-19
A TBX2-HLX Regulatory Axis Is Associated with Advanced Prostate Cancer.
Raju M, Motakatla PI, Khedmatgozar H, Nandana R, Jiang D, Niu Z, Vafa R, Dutta S, Tripathi M Biomedicines 2026-08-20
Integrated blood transcriptomic and metabolomic analyses reveal potential biomarkers associated with residual feed intake in meat ducks.
Zhuang Z, Li Y, Lu Y, Bai H, Bi Y, Wang Z, Chen S, Chang G, Jiang Y Poult Sci IF: 4.5 2026-03-00
BACH1 as a key driver in rheumatoid arthritis fibroblast-like synoviocytes identified through gene network analysis.
Pelissier A, Laragione T, Harris C, Rodríguez Martínez M, Gulko PS Life Sci Alliance 2025-01-00
Artificial intelligence in drug development: reshaping the therapeutic landscape.
Niazi SK, Mariam Z Ther Adv Drug Saf IF: 3.3 2025-00-00
Expression of Dlx-5 and HLX Proteins in Odontogenic Cysts.
Ateş S, Topaloğlu U, Akbalik ME, Keleş Karagözoğlu Ş Life (Basel) 2025-02-14
Breast Cancer Bone Metastasis: Novel Prognostic Biomarkers Identified.
Chu M, Zhang Y, Chen J, Cong H, Yin Y, Chen H Phenomics IF: 5.5 2025-08-00

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