IER3 (immediate early response 3)
- symbol:
- IER3
- locus group:
- protein-coding gene
- location:
- 6p21.33
- gene_family:
- alias symbol:
- IEX-1|DIF-2|PRG1|IEX-1L
- alias name:
- None
- entrez id:
- 8870
- ensembl gene id:
- ENSG00000137331
- ucsc gene id:
- uc003nrn.4
- refseq accession:
- NM_003897
- hgnc_id:
- HGNC:5392
- approved reserved:
- 1999-09-30
IER3（Immediate Early Response 3），也称为IEX-1或DIF-2，是一种快速早期反应基因，属于IEG（Immediate Early Gene）家族。该基因在细胞受到外界刺激（如应激、生长因子或细胞因子）后迅速被激活，无需新蛋白合成即可表达。IER3的主要功能包括调控细胞凋亡、增殖和应激反应。它通过抑制促凋亡蛋白（如BAX）的活性或激活抗凋亡通路（如NF-κB）来保护细胞免受应激诱导的死亡，同时在炎症和免疫反应中起重要作用。IER3的表达产物是一种小分子蛋白，定位于细胞质和线粒体，通过与多种信号分子相互作用来调节细胞命运。突变或异常表达可能影响其功能，导致细胞凋亡失调，与癌症、自身免疫疾病和神经退行性疾病相关。例如，IER3在某些肿瘤中过表达可能促进细胞存活和耐药性，而在神经系统中表达降低可能增加神经元对损伤的敏感性。IER3的过表达通常增强细胞抗凋亡能力，可能促进肿瘤发展；而低表达可能使细胞对应激更敏感，加剧组织损伤。IER3属于IEG家族，该家族成员共同特点是对外界刺激快速响应，参与细胞周期、分化及应激反应的调控。家族成员通常作为转录因子或信号调节分子，在短期和长期细胞适应中起桥梁作用。
This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008]
Gene Ontology
Subcellular localization of IER3 (and its protein):
- plasma membrane
- cytoplasm
- extracellular
- golgi
- vesicle
- cytoskeleton
- endoplasmic reticulum
- nucleus
- endosome
- lysosome
- mitochondrion
Gene Ontology (GO) terms for IER3:
| Interacting Gene | Interaction | Source/Score |
| Disease | Score | NofPmids | NofSnps | Source |
| Hypertensive disease | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Arsenic Poisoning | 0.12 | 1 | 0 | CTD_human |
| Dermatologic disorders | 0.12 | 1 | 0 | CTD_human |
| Lupus Erythematosus, Systemic | 0.007372538 | 3 | 4 | BeFree_GAD |
| Autoimmune Diseases | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Glioma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| leukemia | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Pancreatic Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Infection | 0.00272435 | 1 | 0 | LHGDN |
| Behcet Syndrome | 0.002367032 | 1 | 10 | GAD |
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