LYN (LYN proto-oncogene, Src family tyrosine kinase)

Gene Basic Information

Gene Basic Information

symbol
LYN
locus group
protein-coding gene
location
8q12.1
gene_family
SH2 domain containing
alias symbol
JTK8
alias name
None
entrez id
4067
ensembl gene id
ENSG00000254087
ucsc gene id
uc003xsk.5
refseq accession
NM_002350
hgnc_id
HGNC:6735
approved reserved
1986-01-01

Chromosome Location

Chromosome Location

8q12.1

Gene Summary

Gene Summary

ChineseEnglish

This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

OMIM entry for LYN     Wikipedia entry for LYN

Gene Sequence

Gene Sequence

Nucleotide sequence of LYN:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MGCIKSKGKD SLSDDGVDLK TQPVRNTERT IYVRDPTSNK
41QQRPVPESQL LPGQRFQTKD PEEQGDIVVA LYPYDGIHPD
81 DLSFKKGEK MKVLEEHGEW WKAKSLLTKK EGFIPSNYVA
121KLNTLETEEW FFKDITRKDA ERQLLAPGNS AGAFLIRESE
161T LKGSFSLS VRDFDPVHGD VIKHYKIRSL DNGGYYISPR
201ITFPCISDMI KHYQKQADGL CRRLEKACIS PKPQKPWDKD
241AW EIPRESI KLVKRLGAGQ FGEVWMGYYN NSTKVAVKTL
281KPGTMSVQAF LEEANLMKTL QHDKLVRLYA VVTREEPIYI
321ITE YMAKGS LLDFLKSDEG GKVLLPKLID FSAQIAEGMA
361YIERKNYIHR DLRAANVLVS ESLMCKIADF GLARVIEDNE
401YTAR EGAKF PIKWTAPEAI NFGCFTIKSD VWSFGILLYE
441IVTYGKIPYP GRTNADVMTA LSQGYRMPRV ENCPDELYDI
481MKMCW KEKA EERPTFDYLQ SVLDDFYTAT EGQYQQQP
Structure predicted by AlphaFold DB(UniProt: P07948). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of LYN:           Showing partial SNPs
rs13636       rs167999       rs182832       rs182833       rs333612       rs333614       rs333615       rs333616       rs333617       rs333618       rs333619       rs867586       rs868541       rs907422       rs907423       rs907424       rs907425      

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CCAACGTCCAATAAACAGCA
59
CCTCTGGATCTTTAGTTTGAAACC
59
TCTGCTCAGATTGCAGAGG
59
CCAGAACATTAGCTGCTCG
58
TCTGCTCAGATTGCAGAGG
59
CAGAACATTAGCTGCTCGC
59

Gene Ontology

Subcellular localization of LYN (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for LYN:

GO ID
Protein
Source DB
GO:0001782
P07948 (UniProtKB)
ISS
GO:0001817
P07948 (UniProtKB)
ISS
GO:0001932
P07948 (UniProtKB)
TAS
GO:0001933
P07948 (UniProtKB)
ISS
GO:0002223
P07948 (UniProtKB)
TAS
GO:0002250
P07948 (UniProtKB)
IEA
GO:0002431
P07948 (UniProtKB)
ISS
GO:0002431
P07948 (UniProtKB)
IBA
GO:0002513
P07948 (UniProtKB)
ISS
GO:0002513
P07948 (UniProtKB)
TAS
GO:0002553
P07948 (UniProtKB)
IEA
GO:0002576
P07948 (UniProtKB)
ISS
GO:0002576
P07948 (UniProtKB)
IBA
GO:0002762
P07948 (UniProtKB)
IEA
GO:0002768
P07948 (UniProtKB)
ISS
GO:0002768
P07948 (UniProtKB)
TAS
GO:0002774
P07948 (UniProtKB)
ISS
GO:0002902
P07948 (UniProtKB)
IBA
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
IDA
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
TAS
GO:0004713
P07948 (UniProtKB)
TAS
GO:0004713
P07948 (UniProtKB)
TAS
GO:0004713
P07948 (UniProtKB)
TAS
GO:0004713
P07948 (UniProtKB)
TAS
GO:0004713
P07948 (UniProtKB)
TAS
GO:0004715
P07948 (UniProtKB)
IBA
GO:0004715
P07948 (UniProtKB)
TAS
GO:0004716
P07948 (UniProtKB)
TAS
GO:0005102
P07948 (UniProtKB)
IBA
GO:0005161
P07948 (UniProtKB)
IEA
GO:0005178
P07948 (UniProtKB)
IEA
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005524
P07948 (UniProtKB)
IEA
GO:0005634
P07948 (UniProtKB)
ISS
GO:0005634
P07948 (UniProtKB)
IDA
GO:0005737
P07948 (UniProtKB)
ISS
GO:0005758
P07948 (UniProtKB)
IEA
GO:0005794
P07948 (UniProtKB)
IDA
GO:0005794
P07948 (UniProtKB)
IDA
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
IDA
GO:0005886
P07948 (UniProtKB)
IDA
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005913
P07948 (UniProtKB)
IEA
GO:0006468
P07948 (UniProtKB)
IDA
GO:0006954
P07948 (UniProtKB)
IBA
GO:0006974
P07948 (UniProtKB)
IDA
GO:0006974
P07948 (UniProtKB)
IDA
GO:0006991
P07948 (UniProtKB)
IEA
GO:0007165
P07948 (UniProtKB)
TAS
GO:0007169
P07948 (UniProtKB)
IMP
GO:0007417
P07948 (UniProtKB)
IBA
GO:0007596
P07948 (UniProtKB)
TAS
GO:0008284
P07948 (UniProtKB)
ISS
GO:0008285
P07948 (UniProtKB)
IMP
GO:0009636
P07948 (UniProtKB)
IEA
GO:0009725
P07948 (UniProtKB)
ISS
GO:0009743
P07948 (UniProtKB)
IEA
GO:0010976
P07948 (UniProtKB)
IMP
GO:0014003
P07948 (UniProtKB)
IEA
GO:0014069
P07948 (UniProtKB)
IEA
GO:0014070
P07948 (UniProtKB)
IEA
GO:0016032
P07948 (UniProtKB)
IEA
GO:0017124
P07948 (UniProtKB)
IEA
GO:0018108
P07948 (UniProtKB)
IDA
GO:0019899
P07948 (UniProtKB)
IPI
GO:0019899
P07948 (UniProtKB)
IPI
GO:0023014
P07948 (UniProtKB)
IEA
GO:0030061
P07948 (UniProtKB)
IEA
GO:0030168
P07948 (UniProtKB)
TAS
GO:0030218
P07948 (UniProtKB)
ISS
GO:0030335
P07948 (UniProtKB)
IEA
GO:0030889
P07948 (UniProtKB)
IBA
GO:0031175
P07948 (UniProtKB)
IEA
GO:0031234
P07948 (UniProtKB)
IBA
GO:0031295
P07948 (UniProtKB)
TAS
GO:0031295
P07948 (UniProtKB)
TAS
GO:0031625
P07948 (UniProtKB)
IEA
GO:0031663
P07948 (UniProtKB)
ISS
GO:0031668
P07948 (UniProtKB)
IEA
GO:0032868
P07948 (UniProtKB)
IEA
GO:0033003
P07948 (UniProtKB)
ISS
GO:0033628
P07948 (UniProtKB)
IMP
GO:0034136
P07948 (UniProtKB)
ISS
GO:0034144
P07948 (UniProtKB)
ISS
GO:0034605
P07948 (UniProtKB)
IEA
GO:0034666
P07948 (UniProtKB)
IEA
GO:0038083
P07948 (UniProtKB)
IBA
GO:0038095
P07948 (UniProtKB)
TAS
GO:0038096
P07948 (UniProtKB)
TAS
GO:0042493
P07948 (UniProtKB)
IEA
GO:0042531
P07948 (UniProtKB)
ISS
GO:0042629
P07948 (UniProtKB)
IEA
GO:0043015
P07948 (UniProtKB)
IEA
GO:0043200
P07948 (UniProtKB)
IEA
GO:0043208
P07948 (UniProtKB)
IEA
GO:0043304
P07948 (UniProtKB)
ISS
GO:0043304
P07948 (UniProtKB)
IBA
GO:0043407
P07948 (UniProtKB)
ISS
GO:0043552
P07948 (UniProtKB)
IEA
GO:0044325
P07948 (UniProtKB)
IPI
GO:0044325
P07948 (UniProtKB)
IPI
GO:0045087
P07948 (UniProtKB)
IBA
GO:0045121
P07948 (UniProtKB)
IDA
GO:0045646
P07948 (UniProtKB)
ISS
GO:0046777
P07948 (UniProtKB)
IDA
GO:0048013
P07948 (UniProtKB)
TAS
GO:0048471
P07948 (UniProtKB)
IDA
GO:0048678
P07948 (UniProtKB)
IEA
GO:0050663
P07948 (UniProtKB)
IEA
GO:0050707
P07948 (UniProtKB)
IEA
GO:0050727
P07948 (UniProtKB)
IEA
GO:0050777
P07948 (UniProtKB)
TAS
GO:0050853
P07948 (UniProtKB)
IEA
GO:0050855
P07948 (UniProtKB)
ISS
GO:0050855
P07948 (UniProtKB)
IBA
GO:0050861
P07948 (UniProtKB)
IEA
GO:0050900
P07948 (UniProtKB)
TAS
GO:0051219
P07948 (UniProtKB)
IEA
GO:0051272
P07948 (UniProtKB)
IDA
GO:0051279
P07948 (UniProtKB)
IEA
GO:0051279
P07948 (UniProtKB)
IEA
GO:0060252
P07948 (UniProtKB)
IEA
GO:0060369
P07948 (UniProtKB)
IEA
GO:0060397
P07948 (UniProtKB)
TAS
GO:0070062
P07948 (UniProtKB)
IDA
GO:0070062
P07948 (UniProtKB)
IDA
GO:0070304
P07948 (UniProtKB)
IDA
GO:0070372
P07948 (UniProtKB)
ISS
GO:0070373
P07948 (UniProtKB)
ISS
GO:0070447
P07948 (UniProtKB)
IEA
GO:0070667
P07948 (UniProtKB)
ISS
GO:0070667
P07948 (UniProtKB)
IBA
GO:0070668
P07948 (UniProtKB)
IMP
GO:0071300
P07948 (UniProtKB)
IMP
GO:0090025
P07948 (UniProtKB)
IMP
GO:0090330
P07948 (UniProtKB)
ISS
GO:0090330
P07948 (UniProtKB)
IBA
GO:0097028
P07948 (UniProtKB)
ISS
GO:0097028
P07948 (UniProtKB)
IBA
GO:1902532
P07948 (UniProtKB)
ISS
GO:2000670
P07948 (UniProtKB)
ISS
GO:2000670
P07948 (UniProtKB)
IBA

Related microRNA

Related microRNA

microRNAs potentially regulating LYN:     

Gene Interactions

Gene Interactions

BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
HIV Infections 0.122367032 2 0 CTD_human_GAD
Lupus Erythematosus, Systemic 0.087729856 3 0 BeFree_GAD_LHGDN_MGD
Parkinsonian Disorders 0.08 1 0 RGD
Endometriosis 0.08 1 0 RGD
Cardiomegaly 0.08 1 0 RGD
Lymphoma 0.008444493 4 0 BeFree_LHGDN
Myeloid Leukemia, Chronic 0.003810118 4 0 BeFree_LHGDN
Lymphoid leukemia 0.00272435 1 0 LHGDN
B-Cell Lymphomas 0.00272435 1 0 LHGDN
Malignant Mixed Tumor 0.00272435 1 0 LHGDN

Related Publications

Related Publications

Tyrosine kinase LYN restricts the replication and virulence of influenza A virus by directly phosphorylating viral nucleoprotein.
Liu J, Huang J, Wang Q, Wei Y, Han L, Li X, Lei C, Deng G, Chen H, Zhu Q, Xu S mBio IF: 5.1 2026-05-13
Role of Src family kinases Fyn and Lyn in arenavirus infection.
Mao W, Zhou M, Peng C, Wan Y, Li L, Hu J, Liu Y, Peng Y, Shan C, Deng F, Yuan Z, Wang W J Virol IF: 4.1 2026-04-21
Deletion of SPI1 in microglia exacerbates amyloid pathology by impairing microglial response in Alzheimer's disease models.
Kim B, Tate MD, Karahan H, Wijeratne HRS, Sharify AD, Wang SS, Kim JR, Al-Amin MM, Hartigan K, Chung S, Dabin LC, Acri DJ, Doud EH, John SK, Mosley AL, Kim J Neuron IF: 16.9 2026-08-05
The Protein Tyrosine Phosphatase CD45 promotes PMN Transepithelial Migration, Antimicrobial Function and Colonic Mucosal Repair.
Miranda J, Fink DJ, Wilson ZS, Hilgarth R, Nusrat A, Parkos CA, Brazil JC bioRxiv 2026-03-27
Mesothelin promotes acute myeloid leukemia progression through LYN-dependent signaling.
Faust JR, Hamill D, Kolb EA, Stevens AM, Gopalakrishnapillai A, Barwe SP J Biol Chem 2026-05-00
KR-62980, a novel PPARγ agonist, inhibits collagen-induced platelet activation and thrombus formation by regulating the GPVI signaling pathway.
Wang SB, Park JW, Kim P, Oh EB, Kim S, Sohn J, Kim T, Ahn JH, Chang TS Biochem Pharmacol IF: 6.5 2026-07-00

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