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PDZK1-ULK1 Axis Triggers Lipophagy to Inhibit Tumor Progression and Sunitinib...

Qi(X),Guo(Y),Yang(Y),Wang(H),Yang(X),Song(... Adv Sci (Weinh) 2026-04-00

...LYN-1604 restores sunitinib sensitivity in PDZK1-knockdown cells and synergizes with sunitinib in xenograft models, redu...

Microglial Lyn Kinase-TRPV4 axis mediates social deficits in a maternal immun...

Islam(R),Zhang(F),Choudhary(HH),Yoshida(J)... J Neuroinflammation 2026-02-19

...Lyn kinase; Lyn was increasing the threshold for TRPV4 responsiveness to LPS. To translate these findings to an in vivo ...

Tussilagone inhibits MRGPRX2-mediated mast cell degranulation and suppresses ...

Yan(PP),Huang(TT),Attiogbe(MKI),Mi(YN),Cao... Toxicol Appl Pharmacol 2026-05-00

...Lyn kinase activation and suppressed SP-and Tween 80-induced β-hexosaminidase release, exhibiting an inhibitory profile ...

Site-Specific Phosphoproteomic Profiling of CAV1 Reveals Co-Regulatory Kinase...

Vaz(CE),Suresh(M),Dcunha(L),Raju(R),Kaneka... Int J Mol Sci 2026-05-12

...LYN, and TEC as potential upstream kinases of CAV1_Y14, whereas CSNK1E and GRK5 were predicted to regulate CAV1_S37. Con...

An Integrated Proteomics and Genomics Approach to Identify Essential Protein ...

Kumar(R),Dasgupta(P),Ray(S),Paul(S) bioRxiv 2026-07-24

...LYN are important for EVT development. Our findings highlight key kinases uniquely required for specific stages of troph...

Immune checkpoints in a genetically engineered mouse model of spontaneous aut...

Yin(M),Hiam-Galvez(KJ),Proekt(I),Chan(J),H... J Immunol 2026-03-17

Engineered mutant AireGW/+Lyn-/- C57BL/6 mice are a model of spontaneous autoimmunity in which 50% of mice develop highl...

ULK1-driven autophagy modulation alters tumor-promoting pathways in triple-ne...

Bal Albayrak(MG),Yanar(S),Korak(T),Akpinar... Med Oncol 2026-03-03

...LYN-1604 or inhibitor MRT68921 at EC₅₀ concentrations. Autophagic activity, validated through LC3B immunoblotting and fl...

Treml4 Drives Microglial Activation via the Lyn/Syk/ERK Pathway in Sepsis-Ass...

Li(R),Xie(J),Li(Q),Ouyang(Y),Zhang(Q),Wang... Neurochem Res 2026-05-20

...Lyn, Syk and ERK. Knockout of Treml4 significantly reversed the phosphorylation of Lyn, Syk, and ERK in the hippocampus,...

When less is more and when it isn't: Microglial Spi1 and the limits of what w...

Koldamova(R),Fitz(NF),Lefterov(I) Neuron 2026-08-05

...Lyn, and Fcgr1, providing new insight into PU.1-dependent regulatory networks and microglial functions in neurodegenerat...

Predicting target interactomes and prognostic biomarkers of Quizartinib in ac...

Hebballi(AP),Hampannavar(GA),Gatibyali(I),... Comput Biol Chem 2026-07-18

...LYN, FLT1, and KDR. Survival analysis identified LYN, FLT3, and PDGFRA as prognostic biomarkers (p < 0.05). Molecular do...

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