ME1 (malic enzyme 1)

Gene Basic Information

Gene Basic Information

symbol
ME1
locus group
protein-coding gene
location
6q14.2
gene_family
-
alias symbol
-
alias name
malate dehydrogenase (oxaloacetate…
entrez id
4199
ensembl gene id
ENSG00000065833
ucsc gene id
uc003pjy.4
refseq accession
NM_002395
hgnc_id
HGNC:6983
approved reserved
2001-06-22

Chromosome Location

Chromosome Location

6q14.2

Gene Summary

Gene Summary

ChineseEnglish

This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]

OMIM entry for ME1     Wikipedia entry for ME1

Gene Sequence

Gene Sequence

Nucleotide sequence of ME1:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MEPEAPRRRH THQRGYLLTR NPHLNKDLAF TLEERQQLNI
41HGLLPPSFNS QEIQVLRVVK NFEHLNSDFD RYLLLMDLQD
81 RNEKLFYRV LTSDIEKFMP IVYTPTVGLA CQQYSLVFRK
121PRGLFITIHD RGHIASVLNA WPEDVIKAIV VTDGERILGL
161G DLGCNGMG IPVGKLALYT ACGGMNPQEC LPVILDVGTE
201NEELLKDPLY IGLRQRRVRG SEYDDFLDEF MEAVSSKYGM
241NC LIQFEDF ANVNAFRLLN KYRNQYCTFN DDIQGTASVA
281VAGLLAALRI TKNKLSDQTI LFQGAGEAAL GIAHLIVMAL
321EKE GLPKEK AIKKIWLVDS KGLIVKGRAS LTQEKEKFAH
361EHEEMKNLEA IVQEIKPTAL IGVAAIGGAF SEQILKDMAA
401FNER PIIFA LSNPTSKAEC SAEQCYKITK GRAIFASGSP
441FDPVTLPNGQ TLYPGQGNNS YVFPGVALGV VACGLRQITD
481NIFLT TAEV IAQQVSDKHL EEGRLYPPLN TIRDVSLKIA
521EKIVKDAYQE KTATVYPEPQ NKEAFVRSQM YSTDYDQILP
561DCYSWP EEV QKIQTKVDQ
Structure predicted by AlphaFold DB(UniProt: P48163). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of ME1:           Showing partial SNPs
rs750384       rs750385       rs750386       rs767144       rs976065       rs983087       rs983140       rs1012741       rs1013317       rs1013318       rs1016242       rs1112482       rs1112483       rs1143795       rs1143796       rs1144177       rs1144178      

Gene Expression

Gene Expression

Tissue expression of ME1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CATGCCTATTGTTTATACTCCCAC
60
AAGAGACCTCTTGGCTTCC
59
TGACTTTGACAGGTATCTTCTC
58
ATGTCAGATGTCAGCACTC
57
ACGGCAGAGAAGAGTAAGAG
59
ATGCCATACTTGGAAGAAACTG
59

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
SP1
ME1
Unknown
9872397

Gene Ontology

Subcellular localization of ME1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for ME1:

GO ID
Protein
Source DB
GO:0004470
P48163 (UniProtKB)
IMP
GO:0004470
P48163 (UniProtKB)
IDA
GO:0004470
P48163 (UniProtKB)
IDA
GO:0004471
P48163 (UniProtKB)
IEA
GO:0004473
P48163 (UniProtKB)
ISS
GO:0004473
P48163 (UniProtKB)
IDA
GO:0005739
P48163 (UniProtKB)
IEA
GO:0005829
P48163 (UniProtKB)
ISS
GO:0005829
P48163 (UniProtKB)
TAS
GO:0005975
P48163 (UniProtKB)
NAS
GO:0006108
P48163 (UniProtKB)
IDA
GO:0006108
P48163 (UniProtKB)
IDA
GO:0006741
P48163 (UniProtKB)
TAS
GO:0008948
P48163 (UniProtKB)
IEA
GO:0009055
P48163 (UniProtKB)
TAS
GO:0009725
P48163 (UniProtKB)
ISS
GO:0009743
P48163 (UniProtKB)
TAS
GO:0030145
P48163 (UniProtKB)
IDA
GO:0043531
P48163 (UniProtKB)
TAS
GO:0050661
P48163 (UniProtKB)
TAS
GO:0051262
P48163 (UniProtKB)
IEA
GO:0051287
P48163 (UniProtKB)
TAS
GO:0055114
P48163 (UniProtKB)
IEA
GO:1902031
P48163 (UniProtKB)
IMP

Related microRNA

Related microRNA

microRNAs potentially regulating ME1:     

Gene Interactions

Gene Interactions

String
BioGrid
mentha
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Liver carcinoma 0.120271442 2 0 BeFree_CTD_human
Obesity 0.12 1 0 CTD_human
Weight Gain 0.12 1 0 CTD_human
Malignant neoplasm of lung 0.002909916 3 0 BeFree_GAD
Sarcoma 0.001085767 4 0 BeFree
Uterine Corpus Sarcoma 0.000814326 3 0 BeFree
Breast Carcinoma 0.000542884 2 0 BeFree
Carcinoma of lung 0.000542884 2 0 BeFree
Glioma 0.000542884 2 0 BeFree
Malignant neoplasm of breast 0.000542884 2 0 BeFree

Related Publications

Related Publications

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A pH-Responsive fluorescence lifetime probe reveals GOT1 phase separation in cellular anti-senescence.
Chen Z, Li J, Bao Y, Wang M, Chen H, Zhang M, Ding L, Wu S, Shen B Smart Mol 2026-09-03
Malic enzyme 1 senses L-lactate to determine tumor heterogeneity.
Cao SY, Hu K, Huang S, Guan XL, Wang J, Shen Y, Ming H, Gu A, Wang C, Shen X, Wu Q, Chen Z, Yin M, Wen W, Lei QY Signal Transduct Target Ther IF: 81.2 2026-09-11
Metabolic circuitry of NADH buffering reveals a vulnerability in redox-adaptive cancer cells.
Li X, Hou P, Zhai X, Li L, Guo Z, Qiao L, Fu Y, Niu J, Chen P, Yang R, Li B Innovation (Camb) IF: 39.5 2026-09-08
Genome-Wide Association Study Revealed Key Genes with the Teat Number in Jishen Black Pigs.
Zhang X, Sun H, Ke J, Chen C, Dong F, Liu S, Jin L, Li J, Bie L, Bai C, Sun B Vet Sci 2026-05-29
Functional DNAzyme-Guided Target Identification and Portable Detection of Colorectal Cancer.
Yan Y, Zheng H, Zhao S, Lin L, Hu Q, Liu J, Gu H JACS Au 2026-06-22
Systemic trade-offs between core and accessory genomes govern stress adaptation in Rhodococcus erythropolis.
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