PTGDS (prostaglandin D2 synthase)

Gene Basic Information

Gene Basic Information

symbol
PTGDS
locus group
protein-coding gene
location
9q34.3
gene_family
Lipocalins
alias symbol
PGDS|L-PGDS
alias name
lipocalin-type prostaglandin D syn…
entrez id
5730
ensembl gene id
ENSG00000107317
ucsc gene id
uc004cke.4
refseq accession
NM_000954
hgnc_id
HGNC:9592
approved reserved
1993-07-13

Chromosome Location

Chromosome Location

9q34.3

Gene Summary

Gene Summary

ChineseEnglish

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

OMIM entry for PTGDS     Wikipedia entry for PTGDS

Gene Sequence

Gene Sequence

Nucleotide sequence of PTGDS:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MATHHTLWMG LALLGVLGDL QAAPEAQVSV QPNFQQDKFL
41GRWFSAGLAS NSSWLREKKA ALSMCKSVVA PATDGGLNLT
81 STFLRKNQC ETRTMLLQPA GSLGSYSYRS PHWGSTYSVS
121VVETDYDQYA LLYSQGSKGP GEDFRMATLY SRTQTPRAEL
161K EKFTAFCK AQGFTEDTIV FLPQTDKCMT EQ
Structure predicted by AlphaFold DB(UniProt: P41222). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of PTGDS:           Showing partial SNPs
rs6926       rs13306       rs4880180       rs10735660       rs34012410       rs34216979       rs34273409       rs34491311       rs34858694       rs34920773       rs35125096       rs35240177       rs35253986       rs35578682       rs140542991       rs142373812       rs181560681      

Gene Expression

Gene Expression

Tissue expression of PTGDS:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TTGTCCATGTGCAAGTCTG
58
TTTCCTGAGGAAGGTGGAG
59
GAGAAATTCACCGCCTTCTG
59
TCATGCACTTATCGGTTTGG
59
AGGAGAATGGCTACTCATCAC
59
GACTTGCACATGGACAACG
60
GAGAAATTCACCGCCTTCTG
59
TCATGCACTTATCGGTTTGG
59
GAGAAATTCACCGCCTTCTG
59
TCATGCACTTATCGGTTTGG
59
GACGGAACAATAGGACTCC
57
AGAGCAGAGACATCCAGAG
58
TTGTCCATGTGCAAGTCTG
58
TTTCCTGAGGAAGGTGGAG
59
AGAAATTCACCGCCTTCTG
58
TCATGCACTTATCGGTTTGG
59
CTACTCCGTGTCAGTGGTG
60
TTCTCCTTTAACTCAGCCCT
58
GACGGAACAATAGGACTCC
57
AGAGCAGAGACATCCAGAG
58

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
HES1
PTGDS
Repression
15743775
NFKB1
PTGDS
Activation
19094210
TFAP2B
PTGDS
Activation
15743775
USF1
PTGDS
Activation
17574780
USF1
PTGDS
Repression
18817855

Gene Ontology

Subcellular localization of PTGDS (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for PTGDS:

GO ID
Protein
Source DB
GO:0005215
H0Y5A1 (UniProtKB)
IEA
GO:0005576
H0Y5A1 (UniProtKB)
IEA
GO:0006629
H0Y5A1 (UniProtKB)
IEA
GO:0006810
H0Y5A1 (UniProtKB)
IEA
GO:0036094
H0Y5A1 (UniProtKB)
IEA
GO:0001516
P41222 (UniProtKB)
ISS
GO:0001516
P41222 (UniProtKB)
IDA
GO:0004667
P41222 (UniProtKB)
ISS
GO:0004667
P41222 (UniProtKB)
IDA
GO:0004667
P41222 (UniProtKB)
TAS
GO:0005215
P41222 (UniProtKB)
ISS
GO:0005501
P41222 (UniProtKB)
ISS
GO:0005504
P41222 (UniProtKB)
IDA
GO:0005515
P41222 (UniProtKB)
IPI
GO:0005576
P41222 (UniProtKB)
IDA
GO:0005615
P41222 (UniProtKB)
IDA
GO:0005789
P41222 (UniProtKB)
TAS
GO:0005791
P41222 (UniProtKB)
IDA
GO:0005794
P41222 (UniProtKB)
ISS
GO:0006810
P41222 (UniProtKB)
ISS
GO:0019371
P41222 (UniProtKB)
TAS
GO:0031965
P41222 (UniProtKB)
IEA
GO:0045187
P41222 (UniProtKB)
ISS
GO:0048471
P41222 (UniProtKB)
IEA
GO:0051384
P41222 (UniProtKB)
IEA
GO:0070062
P41222 (UniProtKB)
IDA
GO:0070062
P41222 (UniProtKB)
IDA
GO:2000255
P41222 (UniProtKB)
IEA
GO:0005215
Q5SQ11 (UniProtKB)
IEA
GO:0006629
Q5SQ11 (UniProtKB)
IEA
GO:0006810
Q5SQ11 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating PTGDS:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Sensorineural Hearing Loss (disorder) 0.080271442 2 0 BeFree_RGD
Diabetes Mellitus, Non-Insulin-Dependent 0.08 1 0 RGD
Pendred's syndrome 0.006786047 25 0 BeFree
Alzheimer's Disease 0.005991584 4 0 BeFree_LHGDN
Asthma 0.004267125 8 0 BeFree_GAD
Atherosclerosis 0.003267234 3 0 BeFree_LHGDN
AIDS Dementia Complex 0.00272435 1 0 LHGDN
Schizophrenia 0.00272435 1 0 LHGDN
Malignant neoplasm of breast 0.002638474 1 0 BeFree_GAD
Carotid Atherosclerosis 0.002638474 1 0 BeFree_GAD

Related Publications

Related Publications

PTGDS is a potential marker for lung adenocarcinoma identified in a pancancer analysis.
Wang R, Shao F, Liu D, Chen J, Zhou Q Sci Rep IF: 4.9 2026-02-06
Identification of cryosensitive niches and a targetable FOS/AP‑1 program in the human ovarian cortex by single‑cell and spatial transcriptomics.
Guo F, Sun D, Ding H, Li Y, Yang B, Guo M, Ma Y, Qiao R, Li S, Zhang L, Zhang Q, Zhang M, Li W BMC Med IF: 8.7 2026-03-03
Discovery and validation of a multi-protein panel for predicting non-fatal major adverse cardiovascular events in diabetic kidney disease.
Jiang L, Chien C, Li T, Zhang H, Zhao T, Wu X Front Endocrinol (Lausanne) IF: 5.7 2026-00-00
CAF-derived PTGDS drives pancreatic cancer neuroendocrine differentiation and chemoresistance via PAQR9-MAPK.
Liang J, Peng W, Luan Z, Liu L, Huang H, Cui H, Cao M, Chen S, Xiong S, Bai S, Chen W, Cheng B, Zhao Y Oncogenesis IF: 6.0 2026-06-11
Integrated multi-omics profiling of treatment-naive cervix uteri premalignant lesions and cervical squamous cell carcinoma reveals ecosystem and drivers underlying cervical cancer progression.
Zhou Y, Luo Y, Ge Y, Wu X, Wu R, Liu H, Tang L, Li Y, Ren C, Zeng X, Hu Y, Liu K, Liu H, Dong Z Cell Death Dis IF: 12.2 2026-06-09
Integrating machine learning with SHAP to uncover multi-tissue molecular signatures in Osteoarthritis progression.
Zhao J, Tao J, Song Y, Yang J, Lin X, Ye Z, Lu C, Zeng M, Chen W, Liu W PLoS One IF: 2.6 None

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