PTPN1基因详情-基因数据库-基因云馆

PTPN1 (protein tyrosine phosphatase non-receptor type 1)

symbol:: PTPN1
locus group:: protein-coding gene
location:: 20q13.13
gene_family:: Protein tyrosine phosphatases, non-receptor type
alias symbol:: None
alias name:: None
entrez id:: 5770
ensembl gene id:: ENSG00000196396
ucsc gene id:: uc002xvl.5
refseq accession:: NM_001278618
hgnc_id:: HGNC:9642
approved reserved:: 1991-09-13

20q13.13

PTPN1（Protein Tyrosine Phosphatase Non-Receptor Type 1）是一种蛋白酪氨酸磷酸酶，属于PTP（Protein Tyrosine Phosphatase）基因家族。该家族的主要功能是通过去磷酸化调控细胞内的信号传导，尤其是参与细胞生长、分化、代谢和免疫反应的调控。PTPN1编码的蛋白质PTP1B在多种组织中表达，包括肝脏、肌肉和脂肪组织，主要定位于内质网膜。PTP1B通过负调控胰岛素受体信号通路影响葡萄糖代谢和能量平衡，是胰岛素和瘦素信号通路的关键负调节因子。PTPN1的突变或异常表达与多种疾病相关，例如2型糖尿病、肥胖和某些癌症。PTPN1功能丧失突变或表达降低会增强胰岛素敏感性，改善血糖控制，但也可能增加癌症风险。相反，PTPN1过表达会抑制胰岛素信号传导，导致胰岛素抵抗，促进糖尿病和肥胖的发生。此外，PTPN1还参与炎症反应和肿瘤发生，其过表达在某些癌症中可能促进肿瘤进展。PTP家族成员均含有高度保守的催化结构域，负责去磷酸化作用，但各成员在组织分布和底物特异性上存在差异。PTPN1作为该家族的重要成员，其功能研究为代谢性疾病和癌症的靶向治疗提供了潜在方向。

中文English

由该基因编码的蛋白质是蛋白质酪氨酸磷酸酶（PTP）家族，其被分离和鉴定根据它的酶活性和氨基酸序列的创始成员。的PTP催化特异性酪氨酸残基的磷酸单酯的水解。 PTP的家族的成员共享高度保守的催化基序，这对于催化活性是必不可少的。的PTPs已知是信令调节多种细胞过程，包括细胞生长，分化，有丝分裂周期，和致癌性转化的分子。此PTP已经显示通过去磷酸化的胰岛素受体激酶的phosphotryosine残基充当胰岛素信号传导的负调节物。此PTP另据报道，以去磷酸化的表皮生长因子受体激酶，以及JAK2和TYK2激酶，这牵涉本PTP在细胞生长控制的作用，和细胞应答干扰素刺激。已发现该基因编码不同亚型的两个转录变异体。 [由RefSeq的，2013年7月提供]

OMIM数据库中对PTPN1基因的介绍 Wikipedia数据库中对PTPN1基因的介绍

PTPN1基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MEMEKEFEQI DKSGSWAAIY QDIRHEASDF PCRVAKLPKN
41KNRNRYRDVS PFDHSRIKLH QEDNDYINAS LIKMEEAQRS
81
YILTQGPLP NTCGHFWEMV WEQKSRGVVM LNRVMEKGSL
121KCAQYWPQKE EKEMIFEDTN LKLTLISEDI KSYYTVRQLE
161L
ENLTTQET REILHFHYTT WPDFGVPESP ASFLNFLFKV
201RESGSLSPEH GPVVVHCSAG IGRSGTFCLA DTCLLLMDKR
241KD
PSSVDIK KVLLEMRKFR MGLIQTADQL RFSYLAVIEG
281AKFIMGDSSV QDQWKELSHE DLEPPPEHIP PPPRPPKRIL
321EPH
NGKCRE FFPNHQWVKE ETQEDKDCPI KEEKGSPLNA
361APYGIESMSQ DTEVRSRVVG GSLRGAQAAS PAKGEPSLPE
401KDED
HALSY WKPFLVNMCV ATVLTAGAYL CYRFLFNSNT

结构预测来自 AlphaFold DB（UniProt: P18031），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

PTPN1基因的碱基突变：仅显示部分snp

rs1057207 rs6096014 rs7266276 rs11906833 rs13036899 rs16995311 rs17847903 rs71350688 rs76160816 rs111787621 rs138099044 rs141167185 rs148213881 rs150709046 rs183482962 rs527394572 rs527774664

PTPN1基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

AGGAGGATAAAGACTGCCC

TTGACTCATGCTTTCGATGC

AGGAGGATAAAGACTGCCC

TTGACTCATGCTTTCGATGC

GTGACTTCCCATGTAGAGTG

CTATGGTCAAAGGGACTGAC

AGGAGGATAAAGACTGCCC

TGACTCATGCTTTCGATGC

AGTGACTTCCCATGTAGAGTG

TATGGTCAAAGGGACTGACG

AGGAGGATAAAGACTGCCC

TGACTCATGCTTTCGATGC

AACCTTACAACCCAAGAAACTC

CTGGTGATTCAGGGACTCC

CATGTAGAGTGGCCAAGCT

TAATCCGACTATGGTCAAAGGG

AACCTTACAACCCAAGAAACTC

CTGGTGATTCAGGGACTCC

转录因子

影响基因

影响类型

参考文献链接（PubMed）

PTPN1

Unknown

22282656

PTPN1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

PTPN1基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0004725

B4DSN5 (UniProtKB)

IEA

GO:0005783

B4DSN5 (UniProtKB)

IDA

GO:0016021

B4DSN5 (UniProtKB)

IEA

GO:0035335

B4DSN5 (UniProtKB)

IEA

GO:0004725

P18031 (UniProtKB)

IDA

GO:0004725

P18031 (UniProtKB)

IDA

GO:0004725

P18031 (UniProtKB)

TAS

GO:0004725

P18031 (UniProtKB)

TAS

GO:0004725

P18031 (UniProtKB)

TAS

GO:0004725

P18031 (UniProtKB)

TAS

GO:0005158

P18031 (UniProtKB)

IEA

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005515

P18031 (UniProtKB)

IPI

GO:0005769

P18031 (UniProtKB)

IDA

GO:0005783

P18031 (UniProtKB)

IDA

GO:0005829

P18031 (UniProtKB)

TAS

GO:0005829

P18031 (UniProtKB)

TAS

GO:0005829

P18031 (UniProtKB)

TAS

GO:0005829

P18031 (UniProtKB)

TAS

GO:0005829

P18031 (UniProtKB)

TAS

GO:0005829

P18031 (UniProtKB)

TAS

GO:0006470

P18031 (UniProtKB)

IMP

GO:0006987

P18031 (UniProtKB)

TAS

GO:0007257

P18031 (UniProtKB)

IEA

GO:0008270

P18031 (UniProtKB)

IDA

GO:0008286

P18031 (UniProtKB)

IEA

GO:0009966

P18031 (UniProtKB)

IMP

GO:0009968

P18031 (UniProtKB)

TAS

GO:0019899

P18031 (UniProtKB)

IPI

GO:0019901

P18031 (UniProtKB)

IPI

GO:0030100

P18031 (UniProtKB)

IDA

GO:0030948

P18031 (UniProtKB)

ISS

GO:0030968

P18031 (UniProtKB)

IDA

GO:0030971

P18031 (UniProtKB)

IPI

GO:0031410

P18031 (UniProtKB)

IEA

GO:0031532

P18031 (UniProtKB)

IMP

GO:0033157

P18031 (UniProtKB)

IMP

GO:0035335

P18031 (UniProtKB)

IMP

GO:0035335

P18031 (UniProtKB)

IDA

GO:0035791

P18031 (UniProtKB)

IMP

GO:0036498

P18031 (UniProtKB)

IEA

GO:0043407

P18031 (UniProtKB)

IMP

GO:0044822

P18031 (UniProtKB)

IDA

GO:0046627

P18031 (UniProtKB)

NAS

GO:0046875

P18031 (UniProtKB)

IPI

GO:0051721

P18031 (UniProtKB)

IEA

GO:0060338

P18031 (UniProtKB)

TAS

GO:0060397

P18031 (UniProtKB)

TAS

GO:0061098

P18031 (UniProtKB)

IDA

GO:0070373

P18031 (UniProtKB)

ISS

GO:0097443

P18031 (UniProtKB)

ISS

GO:0098554

P18031 (UniProtKB)

IDA

GO:1902202

P18031 (UniProtKB)

IMP

GO:1902236

P18031 (UniProtKB)

IEA

GO:1903896

P18031 (UniProtKB)

TAS

GO:1903898

P18031 (UniProtKB)

IDA

GO:1990264

P18031 (UniProtKB)

ISS

GO:2000646

P18031 (UniProtKB)

IMP

GO:0005886

P18031 (UniProtKB)

IDA

可能调控 PTPN1基因的相关microRNA：

hsa-miR-1 hsa-miR-26b hsa-miR-375 hsa-miR-122 hsa-miR-210 hsa-miR-362-3p

String

BioGrid

IntAct

mentha

MINT

Reactome

加载中…

关联基因	作用方式	资源库来源/分值

KEGG
Reactomepathway

名称
4520 Adherens junction [PATH:hsa04520]
4910 Insulin signaling pathway [PATH:hsa04910]

名称
Cytokine Signaling in Immune system
Growth hormone receptor signaling
Hemostasis
Immune System
Integrin alphaIIb beta3 signaling
Interferon alpha/beta signaling
Interferon gamma signaling
Interferon Signaling
Platelet activation, signaling and aggregation
Platelet Aggregation (Plug Formation)
Regulation of IFNA signaling
Regulation of IFNG signaling

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Diabetes Mellitus, Non-Insulin-Dependent	0.147546451	25	1	BeFree_CTD_human_GAD
B-Cell Lymphomas	0.120542884	2	0	BeFree_CTD_human
Hodgkin Disease	0.120271442	1	0	BeFree_CTD_human
Rett Syndrome	0.12	1	0	CTD_human
INSULIN RESISTANCE, SUSCEPTIBILITY TO	0.12	0	1	CLINVAR
Mediastinal Neoplasms	0.12	1	0	CTD_human
Obesity	0.011053172	32	1	BeFree_GAD
Hypertensive disease	0.007915422	4	0	BeFree_GAD
Metabolic Syndrome X	0.006362715	7	0	BeFree_GAD
Diabetes Mellitus	0.005895776	14	0	BeFree_GAD

Sex Differences in Dietary-Induced Liver Steatosis and Insulin Receptor-Related Signaling in Aged Mice Lacking Serotonin Transporter.

Cespuglio R, Zabegalov K, de Munter JPM, Gorlova A, Chaprov K, Rogacheva D, Askarova S, Schmitt-Böhrer A, Deykin A, Lesch KP, Strekalova T Int J Mol Sci IF: 3.226 2026-03-20

Integrating Untargeted Metabolomics and Transcriptomics in Mice with Pulmonary Tuberculosis to Reveal Changes in Linoleic Acid and Its Metabolism in Lung Monocyte-Derived Macrophages.

Sha Y, Zhao X, Zhu H, Li Y, Shao M, Ding S, Zhou H Pathogens 2026-02-27

PTPN1/PTPN2 inhibition improves NK cancer therapy by enhancing IL-2 and mitigating TGFβ1 responses.

Feng CH, Peltier L, Chouleur T, DiPonzio M, Aubry I, Poirier AJ, Cordova ZM, Shen Y, Tabariès S, Cao X, Chen G, Bikfalvi A, Vidal SM, Siegel PM, Laneuville P, Tremblay ML EMBO Rep IF: 6.0 2026-05-00

Machine learning and free energy clustering reveal PAH protein binding linked to AD risk.

Chen C, He Y, Ni Y, Song D, Chu M, Zhang W iScience 2026-04-17

Negative correlation between microRNA and insulin sensitivity gene expression in adipose tissue: potential implications for diabetes and neurodegenerative diseases.

Podraza J, Wąsowski M, Jonas MI, Lisik W, Jonas M, Binda A, Jaworski P, Tarnowski W, Noszczyk B, Puzianowska-Kuźnicka M, Kuryłowicz A Nutr Metab (Lond) IF: 2.974 2026-04-13

Identifying ICAM-1 as a Therapeutic Target for Cytokine Storm in Human Macrophages Through Integrative Bioinformatics Approaches.

Chen S, Wu D, Zheng Z, Luo Y, Zhang L Molecules IF: 2.861 2026-03-27

PTPN1 Regulation via YBX1-PTBP1 Interaction Promotes Fibroblast Activation and Fibrotic Remodeling in the Lung.

Liu H, Xia C, Zhang Y, Gan Y, Cheng L, Wang X, Chang A, Zhao W, Li B, Wang Y, Li Y, Rosas I, Yang J, Yu G, Wang L Int J Biol Sci IF: 11.7 None

Network pharmacology refined with non-ubiquity and decoy-controlled molecular docking reveals insights into Moringa oleifera phytochemicals targeting insulin resistance.

Santos-Enriquez AK, Dayrit FM, de Jesus AJ, Rojas NRL Front Bioinform None

Dietary eriodictyol ameliorates hyperglycemia and multi-organ damage in streptozotocin-induced diabetic mice: involvement of insulin signaling and antioxidant responses.

Deng X, Zheng J, Xiao C J Sci Food Agric IF: 4.0 2026-08-25

PTPN1 and PTPN2 cooperatively set interferon responsiveness thresholds that govern cancer immune evasion.

Poirier AJ, Feng CH, Walback E, Su R, Hincapie AM, Aubry I, Wu C, St-Laurent E, Uttam S, Colalillo B, Hardy S, Doré S, Théberge JF, Tremblay ML Proc Natl Acad Sci U S A IF: 9.5 2026-08-18

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PTPN1 (protein tyrosine phosphatase non-receptor type 1)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因相关评论

基因相关评论

联系地址

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