RNH1 (ribonuclease/angiogenin inhibitor 1)

Gene Basic Information

Gene Basic Information

symbol:
RNH1
locus group:
protein-coding gene
location:
11p15.5
gene_family:
alias symbol:
RAI
alias name:
None
entrez id:
6050
ensembl gene id:
ENSG00000023191
ucsc gene id:
uc001lpq.3
refseq accession:
NM_203389
hgnc_id:
HGNC:10074
approved reserved:
1990-02-24

Chromosome Location

Chromosome Location

11p15.5

Gene Summary

Gene Summary

ChineseEnglish

Ribonuclease inhibitor 1 (RNH1) is a cytoplasmic protein that binds to and inhibits intracellular and extracellular ribonucleases (RNases) across various tissues. By sequestering these enzymes, RNH1 maintains them in a latent form and plays a critical role in regulating RNA turnover, particularly the stability of messenger RNA (mRNA). Beyond its function in controlling intracellular RNase activity, this inhibitor is also implicated in the regulation of angiogenesis.

OMIM entry for RNH1     Wikipedia entry for RNH1

Gene Sequence

Gene Sequence

Nucleotide sequence of RNH1:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MSLDIQSLDI QCEELSDARW AELLPLLQQC QVVRLDDCGL
41TEARCKDISS ALRVNPALAE LNLRSNELGD VGVHCVLQGL
81 QTPSCKIQK LSLQNCCLTG AGCGVLSSTL RTLPTLQELH
121LSDNLLGDAG LQLLCEGLLD PQCRLEKLQL EYCSLSAASC
161E PLASVLRA KPDFKELTVS NNDINEAGVR VLCQGLKDSP
201CQLEALKLES CGVTSDNCRD LCGIVASKAS LRELALGSNK
241LG DVGMAEL CPGLLHPSSR LRTLWIWECG ITAKGCGDLC
281RVLRAKESLK ELSLAGNELG DEGARLLCET LLEPGCQLES
321LWV KSCSFT AACCSHFSSV LAQNRFLLEL QISNNRLEDA
361GVRELCQGLG QPGSVLRVLW LADCDVSDSS CSSLAATLLA
401NHSL RELDL SNNCLGDAGI LQLVESVRQP GCLLEQLVLY
441DIYWSEEMED RLQALEKDKP SLRVIS
结构预测来自 AlphaFold DB（UniProt: P13489），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

Gene Variants

Gene Variants

SNP variants of RNH1:           Showing partial SNPs
rs7983       rs7983       rs10540       rs10540       rs17584       rs17584       rs17585       rs17585       rs176939       rs176939       rs211523       rs211523       rs211524       rs211524       rs211525       rs211525       rs211526      

Gene Expression

Gene Expression

Tissue expression of RNH1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
AGATCCAGAAGCTGAGGAG
58
GAGAGGCTGCAATACTCCA
59
GTGCTCAGGGAATGTATCCA
60
AAAGTGGTCAGGCAGAGAC
60
GGTGTCTCAGAATCTCCGG
60
CCTCACACTGGATGTCCAG
60
TTAACAGTTACACTGGGCC
57
GTTCTTCATGCCATGTTGG
57
GTGTGACATCAGACAACTGC
60
CACACTCCCAGATCCACAG
60
TCTTGACTGACAGAAACGGA
59
CCGGAGATTCTGAGACACC
60
CCTGGACATCCAGTGTGAG
60
GAAGTGCAGAGCTGATGTC
59
TAACAGTTACACTGGGCCG
60
AGTTCTTCATGCCATGTTGG
59
GTGACATCAGACAACTGCC
59
CACACTCCCAGATCCACAG
60
TTTCGTCTTCCTCACTGGT
59
GAGGGCTAAGGAGACAGAG
59

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of RNH1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for RNH1:

GO ID
Protein
Source DB
GO:0005654
E9PIK5 (UniProtKB)
IDA
GO:0005737
E9PIK5 (UniProtKB)
IDA
GO:0005654
E9PIM9 (UniProtKB)
IDA
GO:0005737
E9PIM9 (UniProtKB)
IDA
GO:0005654
E9PLZ3 (UniProtKB)
IDA
GO:0005737
E9PLZ3 (UniProtKB)
IDA
GO:0005654
E9PMJ3 (UniProtKB)
IDA
GO:0005737
E9PMJ3 (UniProtKB)
IDA
GO:0005654
H0YCR7 (UniProtKB)
IDA
GO:0005737
H0YCR7 (UniProtKB)
IDA
GO:0005515
P13489 (UniProtKB)
IPI
GO:0005515
P13489 (UniProtKB)
IPI
GO:0005515
P13489 (UniProtKB)
IPI
GO:0005515
P13489 (UniProtKB)
IPI
GO:0005515
P13489 (UniProtKB)
IPI
GO:0005515
P13489 (UniProtKB)
IPI
GO:0005515
P13489 (UniProtKB)
IPI
GO:0005654
P13489 (UniProtKB)
IDA
GO:0005737
P13489 (UniProtKB)
IDA
GO:0006402
P13489 (UniProtKB)
NAS
GO:0008428
P13489 (UniProtKB)
IDA
GO:0032311
P13489 (UniProtKB)
IPI
GO:0043086
P13489 (UniProtKB)
IEA
GO:0045765
P13489 (UniProtKB)
IDA
GO:0070062
P13489 (UniProtKB)
IDA
GO:0070062
P13489 (UniProtKB)
IDA
GO:0070062
P13489 (UniProtKB)
IDA
GO:0070062
P13489 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating RNH1:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
melanoma 0.002995792 2 0 BeFree_LHGDN
Schizophrenia 0.00272435 1 0 LHGDN
Skin carcinoma 0.002367032 1 0 GAD
Neoplasm Metastasis 0.001628651 6 0 BeFree
Malignant neoplasm of urinary bladder 0.001085767 4 0 BeFree
Carcinoma of bladder 0.001085767 4 0 BeFree
HIV Infections 0.001085767 4 0 BeFree
Colorectal Carcinoma 0.000814326 3 0 BeFree
Carcinogenesis 0.000814326 3 0 BeFree
Experimental Organism Basal Cell Carcinoma 0.000814326 3 0 BeFree

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