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Development of Chimeric Ribonuclease A Inhibitor for Molecular Biology Applicat…

Sukhov(D),Petrova(T),Kruglova(D),Kholoshenko… Curr Issues Mol Biol 2026-06-18

A chimeric RNase A inhibitor (SUMO-RI) was produced by fusing a SUMO domain to the N-terminus of the murine Rnh1 protein...

Genomic landscape and homologous recombination deficiency in malignant germ cel…

Xu(B),Chen(J),Peng(H),Su(X),He(C) J Pathol 2026-06-00

...RNH1) fusion, and MET focal amplification. These findings suggest a promising therapeutic opportunity with poly (ADP-rib...

Cytoplasmic PXR regulates glucose metabolism by binding mRNAs and modulating th…

Wang(X),Wang(Z),Li(S),Pattarayan(D),Wang(Y),… Nat Struct Mol Biol 2025-11-00

...RNH1, an RNase inhibitor, to regulate RNA stability. In colorectal cancer cells, cytoplasmic PXR facilitates glucose upt...

R-loop modulates odor-guided behavior in migratory locusts.

Liu(J),Zhao(L),Yu(J),Qu(J),Ma(Z) Insect Sci 2025-07-28

...RNH1 is also expressed in these 2 brain regions. RNH1 RNA interference (RNAi) knockdown does not affect the locomotion a...

Adar contributes to genome integrity by regulating R-loop homeostasis in Drosop…

Zhang(X),Liu(H),Peng(J),Wang(G),Wu(X),Li(S),… BMC Biol 2025-07-15

...RNH1) suppressed R-loop accumulation and rescued genome instability in Adar-deficient flies. Strikingly, a catalytically...

Comprehensive Epigenome-Wide Profiling Reveals Distinctive DNA Methylation Sign…

Fong-López(AA),Núñez-Enríquez(JC),Bekker-Mén… Int J Mol Sci 2025-10-22

...RNH1), cg20747787, cg05001671, and cg01767116 (FBXL22)-was significantly associated with an increased risk of relapse, h...

Novel angiogenin mutants with increased cytotoxicity enhance the depletion of p…

Cremer(Christian),Braun(Hanna),Mladenov(Rado… Cancer Immunol Immunother 2016-02-29

...RNH1. However, combining the mutations was unsuccessful because although the enzyme retained its higher activity, its su...

Plasma autoantibodies against heat shock protein 70, enolase 1 and ribonuclease…

Rucksaken(Rucksak),Pairojkul(Chawalit),Pinla… PLoS One 2016-01-18

...RNH1) obtained the highest matching scores and were thus selected for further validation. Western blot revealed immunore...

An endogenous ribonuclease inhibitor regulates the antimicrobial activity of ri…

Spencer(John D),Schwaderer(Andrew L),Eichler… Kidney Int 2015-02-09

...RNH1, the gene encoding RI, is constitutively expressed throughout the urinary tract. With pyelonephritis, RNH1 expressi...

Angiogenin mutants as novel effector molecules for the generation of fusion pro…

Cremer(Christian),Vierbuchen(Tim),Hein(Lea),… J Immunother 2015-11-20

...RNH1. The cytotoxic potential of these mutants was compared with wild-type Ang by fusing each to the CD64-specific singl...

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