RARA (retinoic acid receptor alpha)

Gene Basic Information

Gene Basic Information

symbol
RARA
locus group
protein-coding gene
location
17q21.2
gene_family
Nuclear hormone receptors
alias symbol
RAR|NR1B1|RARalpha|RAR-alpha
alias name
None
entrez id
5914
ensembl gene id
ENSG00000131759
ucsc gene id
uc002huk.3
refseq accession
NM_000964
hgnc_id
HGNC:9864
approved reserved
1988-06-09

Chromosome Location

Chromosome Location

17q21.2

Gene Summary

Gene Summary

ChineseEnglish

This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]

OMIM entry for RARA     Wikipedia entry for RARA

Gene Sequence

Gene Sequence

Nucleotide sequence of RARA:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MASNSSSCPT PGGGHLNGYP VPPYAFFFPP MLGGLSPPGA
41LTTLQHQLPV SGYSTPSPAT IETQSSSSEE IVPSPPSPPP
81 LPRIYKPCF VCQDKSSGYH YGVSACEGCK GFFRRSIQKN
121MVYTCHRDKN CIINKVTRNR CQYCRLQKCF EVGMSKESVR
161N DRNKKKKE VPKPECSESY TLTPEVGELI EKVRKAHQET
201FPALCQLGKY TTNNSSEQRV SLDIDLWDKF SELSTKCIIK
241TV EFAKQLP GFTTLTIADQ ITLLKAACLD ILILRICTRY
281TPEQDTMTFS DGLTLNRTQM HNAGFGPLTD LVFAFANQLL
321PLE MDDAET GLLSAICLIC GDRQDLEQPD RVDMLQEPLL
361EALKVYVRKR RPSRPHMFPK MLMKITDLRS ISAKGAERVI
401TLKM EIPGS MPPLIQEMLE NSEGLDTLSG QPGGGGRDGG
441GLAPPPGSCS PSLSPSSNRS SPATHSP
Structure predicted by AlphaFold DB(UniProt: P10276). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of RARA:           Showing partial SNPs
rs2732783       rs7219013       rs34789145       rs58577573       rs67142006       rs71355449       rs71356657       rs73309029       rs73983034       rs76921025       rs78281655       rs79329721       rs79803221       rs114559376       rs116012720       rs116369621       rs116988367      

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
ATCATCAACAAGGTGACCC
57
TTTCTCACAGACTCCTTGGA
58
CTATGCTGGGTGGACTCTC
59
CTCTGGGTCTCAATGGTGG
60
CAAACCACTCCATTGAGACC
59
AAAGCAAGGCTTGTAGATGC
59
ATACACTACGAACAACAGCT
57
CTTGGTGGAGAGTTCACTG
58
CATCATCAACAAGGTGACCC
59
TTCTCACAGACTCCTTGGAC
59
TCAAACCACTCCATTGAGAC
58
AAGCAAGGCTTGTAGATGC
59
ATCATCAACAAGGTGACCC
57
TTTCTCACAGACTCCTTGGA
58
CATCATCAACAAGGTGACCC
59
TTCTCACAGACTCCTTGGAC
59
ATACACTACGAACAACAGCT
57
CTTGGTGGAGAGTTCACTG
58
ATACACTACGAACAACAGCT
57
CTTGGTGGAGAGTTCACTG
58

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
CRABP2
RARA
Activation
16166294
CREBBP
RARA
Unknown
21110951
ESR1
RARA
Activation
9626663
JUN
RARA
Repression
9377582
KLF4
RARA
Repression
19531492
RARA
ABCC3
Repression
17272513
RARA
ANXA8
Repression
1313714
RARA
CCNA1
Repression
11090075
RARA
CDKN1A
Activation
10356361
RARA
CRABP1
Activation
18000064

Gene Ontology

Subcellular localization of RARA (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for RARA:

GO ID
Protein
Source DB
GO:0003707
A8MUP8 (UniProtKB)
IEA
GO:0003708
A8MUP8 (UniProtKB)
IEA
GO:0005634
A8MUP8 (UniProtKB)
IDA
GO:0005737
A8MUP8 (UniProtKB)
IDA
GO:0006351
A8MUP8 (UniProtKB)
IEA
GO:0006355
A8MUP8 (UniProtKB)
IEA
GO:0008270
A8MUP8 (UniProtKB)
IEA
GO:0015629
A8MUP8 (UniProtKB)
IDA
GO:0043401
A8MUP8 (UniProtKB)
IEA
GO:0043565
A8MUP8 (UniProtKB)
IEA
GO:0048384
A8MUP8 (UniProtKB)
IEA
GO:0003707
J3KSJ4 (UniProtKB)
IEA
GO:0003708
J3KSJ4 (UniProtKB)
IEA
GO:0005634
J3KSJ4 (UniProtKB)
IEA
GO:0006351
J3KSJ4 (UniProtKB)
IEA
GO:0006355
J3KSJ4 (UniProtKB)
IEA
GO:0008270
J3KSJ4 (UniProtKB)
IEA
GO:0043401
J3KSJ4 (UniProtKB)
IEA
GO:0043565
J3KSJ4 (UniProtKB)
IEA
GO:0048384
J3KSJ4 (UniProtKB)
IEA
GO:0000122
P10276 (UniProtKB)
IEA
GO:0000790
P10276 (UniProtKB)
IDA
GO:0000900
P10276 (UniProtKB)
IEA
GO:0000977
P10276 (UniProtKB)
IEA
GO:0001657
P10276 (UniProtKB)
IEA
GO:0001843
P10276 (UniProtKB)
IEA
GO:0001889
P10276 (UniProtKB)
IEA
GO:0001972
P10276 (UniProtKB)
IDA
GO:0002068
P10276 (UniProtKB)
IEA
GO:0003148
P10276 (UniProtKB)
IEA
GO:0003417
P10276 (UniProtKB)
IEA
GO:0003700
P10276 (UniProtKB)
IDA
GO:0003700
P10276 (UniProtKB)
IDA
GO:0003707
P10276 (UniProtKB)
IEA
GO:0003708
P10276 (UniProtKB)
IDA
GO:0003713
P10276 (UniProtKB)
IMP
GO:0003713
P10276 (UniProtKB)
IDA
GO:0003713
P10276 (UniProtKB)
IDA
GO:0003714
P10276 (UniProtKB)
IDA
GO:0005102
P10276 (UniProtKB)
IDA
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005515
P10276 (UniProtKB)
IPI
GO:0005634
P10276 (UniProtKB)
IDA
GO:0005634
P10276 (UniProtKB)
IDA
GO:0005634
P10276 (UniProtKB)
IDA
GO:0005634
P10276 (UniProtKB)
IDA
GO:0005654
P10276 (UniProtKB)
TAS
GO:0005654
P10276 (UniProtKB)
TAS
GO:0005654
P10276 (UniProtKB)
TAS
GO:0005737
P10276 (UniProtKB)
IDA
GO:0005737
P10276 (UniProtKB)
IDA
GO:0006367
P10276 (UniProtKB)
TAS
GO:0006468
P10276 (UniProtKB)
IMP
GO:0007165
P10276 (UniProtKB)
IDA
GO:0007281
P10276 (UniProtKB)
IEA
GO:0007283
P10276 (UniProtKB)
IEA
GO:0007565
P10276 (UniProtKB)
IEA
GO:0008134
P10276 (UniProtKB)
IPI
GO:0008134
P10276 (UniProtKB)
IPI
GO:0008144
P10276 (UniProtKB)
IEA
GO:0008270
P10276 (UniProtKB)
IEA
GO:0008284
P10276 (UniProtKB)
IMP
GO:0008285
P10276 (UniProtKB)
IEA
GO:0009986
P10276 (UniProtKB)
IC
GO:0015629
P10276 (UniProtKB)
IDA
GO:0019899
P10276 (UniProtKB)
IPI
GO:0019899
P10276 (UniProtKB)
IPI
GO:0019904
P10276 (UniProtKB)
IPI
GO:0021766
P10276 (UniProtKB)
IEA
GO:0030425
P10276 (UniProtKB)
IEA
GO:0030425
P10276 (UniProtKB)
IEA
GO:0030850
P10276 (UniProtKB)
IEA
GO:0030853
P10276 (UniProtKB)
IDA
GO:0031076
P10276 (UniProtKB)
IEA
GO:0031490
P10276 (UniProtKB)
IDA
GO:0031641
P10276 (UniProtKB)
IEA
GO:0032355
P10276 (UniProtKB)
IEA
GO:0032526
P10276 (UniProtKB)
IMP
GO:0032689
P10276 (UniProtKB)
IDA
GO:0032720
P10276 (UniProtKB)
IDA
GO:0032736
P10276 (UniProtKB)
IDA
GO:0032753
P10276 (UniProtKB)
IDA
GO:0032754
P10276 (UniProtKB)
IDA
GO:0033189
P10276 (UniProtKB)
IEA
GO:0034097
P10276 (UniProtKB)
IEA
GO:0035264
P10276 (UniProtKB)
IEA
GO:0042826
P10276 (UniProtKB)
IEA
GO:0043025
P10276 (UniProtKB)
IEA
GO:0043066
P10276 (UniProtKB)
IEA
GO:0043277
P10276 (UniProtKB)
IMP
GO:0043401
P10276 (UniProtKB)
IEA
GO:0043422
P10276 (UniProtKB)
IPI
GO:0044323
P10276 (UniProtKB)
IDA
GO:0045471
P10276 (UniProtKB)
IEA
GO:0045630
P10276 (UniProtKB)
IDA
GO:0045666
P10276 (UniProtKB)
IEA
GO:0045787
P10276 (UniProtKB)
IMP
GO:0045892
P10276 (UniProtKB)
IDA
GO:0045893
P10276 (UniProtKB)
IDA
GO:0045893
P10276 (UniProtKB)
IMP
GO:0045893
P10276 (UniProtKB)
IDA
GO:0045893
P10276 (UniProtKB)
IDA
GO:0045944
P10276 (UniProtKB)
IDA
GO:0045944
P10276 (UniProtKB)
IMP
GO:0045947
P10276 (UniProtKB)
IEA
GO:0046982
P10276 (UniProtKB)
IDA
GO:0048027
P10276 (UniProtKB)
IEA
GO:0048167
P10276 (UniProtKB)
IEA
GO:0048384
P10276 (UniProtKB)
IMP
GO:0048471
P10276 (UniProtKB)
IEA
GO:0051018
P10276 (UniProtKB)
IDA
GO:0051099
P10276 (UniProtKB)
IMP
GO:0051393
P10276 (UniProtKB)
IPI
GO:0055012
P10276 (UniProtKB)
IEA
GO:0060010
P10276 (UniProtKB)
IEA
GO:0060173
P10276 (UniProtKB)
IEA
GO:0060324
P10276 (UniProtKB)
IEA
GO:0060534
P10276 (UniProtKB)
IEA
GO:0060591
P10276 (UniProtKB)
IEA
GO:0061037
P10276 (UniProtKB)
IEA
GO:0071222
P10276 (UniProtKB)
IEA
GO:0071300
P10276 (UniProtKB)
IDA
GO:0071391
P10276 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating RARA:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Acute Promyelocytic Leukemia 0.347243502 399 1 BeFree_CTD_human_LHGDN_ORPHANET
Mammary Neoplasms 0.127077352 9 0 BeFree_CTD_human_LHGDN
Liver carcinoma 0.121085767 5 0 BeFree_CTD_human
Phyllodes Tumor 0.12 1 0 CTD_human
Neoplasms, Second Primary 0.12 1 0 CTD_human
Sciatic Neuropathy 0.12 1 0 CTD_human
Fibroadenoma 0.12 1 0 CTD_human
Amyotrophic Lateral Sclerosis 0.08 1 0 RGD
Promyelocytic leukemia 0.025244094 93 0 BeFree
leukemia 0.020397866 39 0 BeFree_LHGDN

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