SUMO1 (small ubiquitin like modifier 1)

基因基本信息

基因基本信息

symbol:
SUMO1
locus group:
protein-coding gene
location:
2q33.1
gene_family:
alias symbol:
PIC1|GMP1|SMT3C|SUMO-1|SMT3H3|OFC10
alias name:
None
entrez id:
7341
ensembl gene id:
ENSG00000116030
ucsc gene id:
uc002uyz.2
refseq accession:
NM_003352
hgnc_id:
HGNC:12502
approved reserved:
1996-06-04

基因染色体位置

基因染色体位置

2q33.1

基因简述

基因简述

SUMO1（Small Ubiquitin-like Modifier 1）是一种小泛素样修饰蛋白，属于SUMO基因家族（包括SUMO1、SUMO2、SUMO3和SUMO4）。该家族成员通过共价结合靶蛋白（称为SUMO化修饰，SUMOylation）调控其功能，类似于泛素化（ubiquitination），但不会导致蛋白降解，而是影响蛋白稳定性、亚细胞定位、转录活性或蛋白相互作用。SUMO1在进化中高度保守，主要表达于细胞核，参与DNA损伤修复、细胞周期调控、信号转导和应激反应等过程。其作用位点通常为靶蛋白的赖氨酸残基（如转录因子p53、核孔蛋白RanGAP1）。SUMO1突变可能导致修饰异常，例如SUMO1第93位甘氨酸突变为天冬氨酸（G93D）会削弱其与靶蛋白结合能力，引发神经发育缺陷或心血管疾病。研究发现SUMO1与阿尔茨海默病（淀粉样蛋白沉积异常）、癌症（如抑制肿瘤 suppressor p53的活性）及先天性心脏病（如NOTCH1信号通路失调）相关。SUMO1过表达可能增强靶蛋白的稳定性（如稳定HIF-1α促进肿瘤血管生成），但也会干扰正常SUMO化平衡，导致细胞凋亡异常；而表达降低则可能影响基因组稳定性（如削弱DNA修复蛋白Rad51的功能）。SUMO家族共性包括：C末端具有保守的"GG" motif（用于与靶蛋白结合）、依赖E1/E2/E3酶级联反应进行修饰，并通过SENP去SUMO化酶（SUMO-specific proteases）动态调控。需注意"SUMO化"早期曾被译为"类泛素化"，但当前学界统一使用"SUMO化修饰"（原英文：SUMOylation）。

中文English

无

OMIM数据库中对SUMO1基因的介绍     Wikipedia数据库中对SUMO1基因的介绍

基因序列

基因序列

SUMO1基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MSDQEAKPST EDLGDKKEGE YIKLKVIGQD SSEIHFKVKM
41TTHLKKLKES YCQRQGVPMN SLRFLFEGQR IADNHTPKEL
81 GMEEEDVIE VYQEQTGGHS TV
结构预测来自 AlphaFold DB（UniProt: P63165），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

SUMO1基因的碱基突变：           仅显示部分snp
rs1050860       rs2176167       rs2176168       rs2350359       rs2350360       rs3136634       rs3754931       rs3769816       rs3769817       rs3835911       rs4675272       rs4675273       rs6435133       rs6435134       rs6435135       rs6435137       rs6435138      

基因表达

基因表达

SUMO1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CCTTCAACTGAGGACTTGG
58
GAATCTCACTGCTATCCTGTC
58
CCTTCAACTGAGGACTTGG
58
GAATCTCACTGCTATCCTGTC
58
TCAAAGACAGGGTGTTCCA
59
ATCTTCTTCCTCCATTCCCAG
59
ACCTTCAACTGAGGACTTGG
60
ATCTCACTGCTATCCTGTCC
59
TCTGACCAGGAATCACTTAACC
60
CTTTATCTGCCATCATGGTGTG
60
CCTTCAACTGAGGACTTGG
58
GAATCTCACTGCTATCCTGTC
58
CCTTCAACTGAGGACTTGG
58
GAATCTCACTGCTATCCTGTC
58
CTTCAACTGAGGACTTGGG
58
AAGAGAAACCTGTCTTTGACAG
59
TCTGACCAGGATAGCAGTG
59
TGAGTGAATTCATTGGAACACC
59
TCAAAGACAGGGTGTTCCA
59
ATCTTCTTCCTCCATTCCCAG
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
BCL6
SUMO1
Repression
22723377
GATA4
SUMO1
Unknown
15337742
STAT5A
SUMO1
Repression
22723377
YBX1
SUMO1
Repression
20596676

基因本体信息

SUMO1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

SUMO1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005634
B8ZZJ0 (UniProtKB)
IDA
GO:0005730
B8ZZJ0 (UniProtKB)
IDA
GO:0031965
B8ZZJ0 (UniProtKB)
IDA
GO:0005634
B8ZZN6 (UniProtKB)
IDA
GO:0005730
B8ZZN6 (UniProtKB)
IDA
GO:0031965
B8ZZN6 (UniProtKB)
IDA
GO:0005634
B9A032 (UniProtKB)
IDA
GO:0005730
B9A032 (UniProtKB)
IDA
GO:0031965
B9A032 (UniProtKB)
IDA
GO:0000792
P63165 (UniProtKB)
IEA
GO:0001650
P63165 (UniProtKB)
IEA
GO:0001741
P63165 (UniProtKB)
IEA
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005515
P63165 (UniProtKB)
IPI
GO:0005634
P63165 (UniProtKB)
IDA
GO:0005634
P63165 (UniProtKB)
IDA
GO:0005634
P63165 (UniProtKB)
IDA
GO:0005634
P63165 (UniProtKB)
IDA
GO:0005643
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005654
P63165 (UniProtKB)
TAS
GO:0005730
P63165 (UniProtKB)
IDA
GO:0005737
P63165 (UniProtKB)
IEA
GO:0005886
P63165 (UniProtKB)
IDA
GO:0006281
P63165 (UniProtKB)
TAS
GO:0006303
P63165 (UniProtKB)
TAS
GO:0008134
P63165 (UniProtKB)
ISS
GO:0015459
P63165 (UniProtKB)
IDA
GO:0016032
P63165 (UniProtKB)
IEA
GO:0016604
P63165 (UniProtKB)
IDA
GO:0016605
P63165 (UniProtKB)
IDA
GO:0016607
P63165 (UniProtKB)
IEA
GO:0016925
P63165 (UniProtKB)
IDA
GO:0016925
P63165 (UniProtKB)
IDA
GO:0016925
P63165 (UniProtKB)
IDA
GO:0016925
P63165 (UniProtKB)
IDA
GO:0016925
P63165 (UniProtKB)
IDA
GO:0016925
P63165 (UniProtKB)
IDA
GO:0016925
P63165 (UniProtKB)
IDA
GO:0016925
P63165 (UniProtKB)
TAS
GO:0016925
P63165 (UniProtKB)
TAS
GO:0016925
P63165 (UniProtKB)
TAS
GO:0016925
P63165 (UniProtKB)
TAS
GO:0016925
P63165 (UniProtKB)
TAS
GO:0016925
P63165 (UniProtKB)
TAS
GO:0016925
P63165 (UniProtKB)
TAS
GO:0016925
P63165 (UniProtKB)
TAS
GO:0016925
P63165 (UniProtKB)
TAS
GO:0016925
P63165 (UniProtKB)
TAS
GO:0016925
P63165 (UniProtKB)
TAS
GO:0016925
P63165 (UniProtKB)
TAS
GO:0016925
P63165 (UniProtKB)
TAS
GO:0030425
P63165 (UniProtKB)
IEA
GO:0030578
P63165 (UniProtKB)
IEA
GO:0031334
P63165 (UniProtKB)
IDA
GO:0031386
P63165 (UniProtKB)
IBA
GO:0031625
P63165 (UniProtKB)
IPI
GO:0031965
P63165 (UniProtKB)
IDA
GO:0032436
P63165 (UniProtKB)
IDA
GO:0032880
P63165 (UniProtKB)
TAS
GO:0043392
P63165 (UniProtKB)
IMP
GO:0043433
P63165 (UniProtKB)
IMP
GO:0044325
P63165 (UniProtKB)
IPI
GO:0044822
P63165 (UniProtKB)
IDA
GO:0045202
P63165 (UniProtKB)
IEA
GO:0045759
P63165 (UniProtKB)
IDA
GO:0045892
P63165 (UniProtKB)
IMP
GO:0045892
P63165 (UniProtKB)
IDA
GO:0050821
P63165 (UniProtKB)
IDA
GO:0060021
P63165 (UniProtKB)
ISS
GO:0060334
P63165 (UniProtKB)
TAS
GO:0070911
P63165 (UniProtKB)
TAS
GO:0086004
P63165 (UniProtKB)
IEA
GO:0090204
P63165 (UniProtKB)
IEA
GO:1901896
P63165 (UniProtKB)
IEA
GO:1902260
P63165 (UniProtKB)
IDA
GO:0008076
P63165 (UniProtKB)
IDA
GO:0016605
P63165 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 SUMO1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String
BioGrid
IntAct
mentha
MINT
Reactome
加载中…
关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
OROFACIAL CLEFT 10 0.24 0 0 CLINVAR_CTD_human
Cleft Palate 0.130096888 5 0 BeFree_CTD_human_GAD_LHGDN
Cleft Lip 0.130096888 5 0 BeFree_CTD_human_GAD_LHGDN
Neoplasm Invasiveness 0.12 1 0 CTD_human
Cytomegalovirus Infections 0.0054487 2 0 LHGDN
Rheumatoid Arthritis 0.003810118 4 0 BeFree_LHGDN
Neurodegenerative Disorders 0.002995792 2 0 BeFree_LHGDN
Osteosarcoma 0.00272435 1 0 LHGDN
leukemia 0.00272435 1 0 LHGDN
Glioma 0.00272435 1 0 LHGDN

基因相关文献

基因相关文献

SUMOylation of EphB4 enhances its stability in prostate cancer.
Maharaj MSN, Mertens-Walker I, Lisle JE, Herington A, Stephens C, Chai M, Meutermans W, Stephenson SA Br J Cancer IF: 7.8 2026-07-00
PIAS4 inhibition induces cell cycle arrest and exhibits a synergistic effect in combination with CDK4/6 inhibitor in breast cancer treatment.
Chen H, Hu X, Feng L, Cheng X, Zhu L, Xu F, Zhu T, Gao Y, Wang J, Jin H, Jiang Z Oncogene IF: 9.1 2026-05-00
SUMO mediates the coordinate regulation of meiotic chromosome length and crossover rate.
Yun Y, Qiao H, White M, Sandhu S, Qiu W, Bourne S, Deshpande A, Bhatt S, Sharma A, Bailey L, Tran H, Van B, Rao HBDP, Hunter N bioRxiv 2026-03-11
Denaturing SUMO Immunoprecipitation From Mitotic Cells.
Walker AK, Lanz AJ, Morris JR Bio Protoc 2026-04-05
Proteomic insights into the effects of cryopreservation on sperm of endangered Eld's deer (Rucervus eldii).
Nijaran M, Roytrakul S, Phaonakrop N, Thongphakdee A, Boonorrana I, Kiatsomboon S, Karoon S, Suriyaphol G Reprod Biol IF: 2.5 2026-06-00
Neurokinin-1 regulates progression of triple negative breast cancer by enhancing G3BP2 SUMOylation.
Bao L, Kong W, Pan X, Liu Y, Zhang X, Wang J Cell Signal IF: 4.7 2026-08-25
DACH1 SUMOylation protects against diabetic cardiomyopathy by suppressing endoplasmic reticulum stress.
Lin J, Liu N, Li B, Wang Y, Li C, Yin Y, Ma H, Yu L, Zhou J J Adv Res IF: 17.1 2026-08-08
Protein SUMOylation confers sorafenib resistance in human hepatocellular carcinoma via the induction of PKM2-mediated glycolysis.
Yuan H, Lu Y, Jiang Z, Chan YT, Wu J, Feng Z, Xu L, Li Q, Lu P, Kwok CF, Fong TL, Huang Q, Wei L, Feng Y, Chen ZS, Wang N Drug Resist Updat IF: 22.0 2026-09-00

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