SYK (spleen associated tyrosine kinase)

Gene Basic Information

Gene Basic Information

symbol
SYK
locus group
protein-coding gene
location
9q22.2
gene_family
SH2 domain containing
alias symbol
-
alias name
None
entrez id
6850
ensembl gene id
ENSG00000165025
ucsc gene id
uc004aqz.4
refseq accession
NM_001135052
hgnc_id
HGNC:11491
approved reserved
1994-12-13

Chromosome Location

Chromosome Location

9q22.2

Gene Summary

Gene Summary

ChineseEnglish

SYK (spleen tyrosine kinase) is a non-receptor tyrosine kinase belonging to the SYK family, which also includes ZAP-70, and is predominantly expressed in hematopoietic lineages such as B cells, T cells, and macrophages, where it plays a pivotal role in immune receptor signal transduction. Functionally, SYK is recruited to the cytoplasmic tails of activated immune receptors, such as the B-cell receptor (BCR) and Fc receptors, by binding to phosphorylated immunoreceptor tyrosine-based activation motifs (ITAMs); its distinctive dual SH2 domains allow it to simultaneously engage two phosphorylated ITAMs, thereby amplifying downstream signaling cascades including PI3K-AKT, MAPK, and NF-κB pathways that govern immune cell proliferation, differentiation, survival, and inflammatory responses. This signaling activity is spatially concentrated at the immunological synapse, such as the contact site between B cells and antigens, and within inflammatory lesions. Dysregulation of SYK activity has significant pathological implications: gain-of-function mutations or overexpression can lead to excessive immune activation, contributing to autoimmune disorders like rheumatoid arthritis, allergic diseases, and certain hematological malignancies including diffuse large B-cell leukemia, whereas loss-of-function mutations may result in immunodeficiency. Consequently, SYK is an attractive therapeutic target, with inhibitors currently under investigation or used to modulate immune responses in conditions such as rheumatoid arthritis, leveraging the potential of reduced SYK expression to suppress aberrant inflammatory reactions.

OMIM entry for SYK     Wikipedia entry for SYK

Gene Sequence

Gene Sequence

Nucleotide sequence of SYK:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MASSGMADSA NHLPFFFGNI TREEAEDYLV QGGMSDGLYL
41LRQSRNYLGG FALSVAHGRK AHHYTIEREL NGTYAIAGGR
81 THASPADLC HYHSQESDGL VCLLKKPFNR PQGVQPKTGP
121FEDLKENLIR EYVKQTWNLQ GQALEQAIIS QKPQLEKLIA
161T TAHEKMPW FHGKISREES EQIVLIGSKT NGKFLIRARD
201NNGSYALCLL HEGKVLHYRI DKDKTGKLSI PEGKKFDTLW
241QL VEHYSYK ADGLLRVLTV PCQKIGTQGN VNFGGRPQLP
281GSHPATWSAG GIISRIKSYS FPKPGHRKSS PAQGNRQEST
321VSF NPYEPE LAPWAADKGP QREALPMDTE VYESPYADPE
361EIRPKEVYLD RKLLTLEDKE LGSGNFGTVK KGYYQMKKVV
401KTVA VKILK NEANDPALKD ELLAEANVMQ QLDNPYIVRM
441IGICEAESWM LVMEMAELGP LNKYLQQNRH VKDKNIIELV
481HQVSM GMKY LEESNFVHRD LAARNVLLVT QHYAKISDFG
521LSKALRADEN YYKAQTHGKW PVKWYAPECI NYYKFSSKSD
561VWSFGV LMW EAFSYGQKPY RGMKGSEVTA MLEKGERMGC
601PAGCPREMYD LMNLCWTYDV ENRPGFAAVE LRLRNYYYDV
641VN
Structure predicted by AlphaFold DB(UniProt: P43405). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of SYK:           Showing partial SNPs
rs8773       rs13559       rs14979       rs158507       rs158685       rs158686       rs158687       rs158688       rs158689       rs158690       rs167063       rs167078       rs169724       rs182343       rs182361       rs187306       rs188312      

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GTGCTGGACATACGATGTG
59
ACCACGTCATAGTAGTAATTGC
58
GTGCTGGACATACGATGTG
59
ACCACGTCATAGTAGTAATTGC
58
GTGCTGGACATACGATGTG
59
ACCACGTCATAGTAGTAATTGC
58
GTGCTGGACATACGATGTG
59
ACCACGTCATAGTAGTAATTGC
58
AAATACAGGTGGACACCTG
57
AGGTAATCTTCTGCCTCCT
57
AACTACTACAAGGCCCAGAC
59
GGAGAACTTGTAGTAGTTGATGC
59
AACTACTACAAGGCCCAGAC
59
GGAGAACTTGTAGTAGTTGATGC
59
AACTACTACAAGGCCCAGAC
59
GGAGAACTTGTAGTAGTTGATGC
59
AAATACAGGTGGACACCTG
57
GGTAATCTTCTGCCTCCTC
57
AACTACTACAAGGCCCAGAC
59
GGAGAACTTGTAGTAGTTGATGC
59

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
JUN
SYK
Unknown
22354960

Gene Ontology

Subcellular localization of SYK (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for SYK:

GO ID
Protein
Source DB
GO:0001525
P43405 (UniProtKB)
IEA
GO:0001945
P43405 (UniProtKB)
ISS
GO:0002092
P43405 (UniProtKB)
IEA
GO:0002223
P43405 (UniProtKB)
TAS
GO:0002250
P43405 (UniProtKB)
ISS
GO:0002250
P43405 (UniProtKB)
IBA
GO:0002281
P43405 (UniProtKB)
ISS
GO:0002281
P43405 (UniProtKB)
IBA
GO:0002283
P43405 (UniProtKB)
ISS
GO:0002283
P43405 (UniProtKB)
IBA
GO:0002366
P43405 (UniProtKB)
ISS
GO:0002554
P43405 (UniProtKB)
ISS
GO:0004672
P43405 (UniProtKB)
NAS
GO:0004672
P43405 (UniProtKB)
IDA
GO:0004674
P43405 (UniProtKB)
IDA
GO:0004713
P43405 (UniProtKB)
EXP
GO:0004713
P43405 (UniProtKB)
EXP
GO:0004713
P43405 (UniProtKB)
EXP
GO:0004713
P43405 (UniProtKB)
EXP
GO:0004713
P43405 (UniProtKB)
EXP
GO:0004713
P43405 (UniProtKB)
EXP
GO:0004713
P43405 (UniProtKB)
TAS
GO:0004713
P43405 (UniProtKB)
TAS
GO:0004713
P43405 (UniProtKB)
TAS
GO:0004713
P43405 (UniProtKB)
TAS
GO:0004713
P43405 (UniProtKB)
TAS
GO:0004713
P43405 (UniProtKB)
TAS
GO:0004713
P43405 (UniProtKB)
TAS
GO:0004713
P43405 (UniProtKB)
TAS
GO:0004715
P43405 (UniProtKB)
IDA
GO:0004715
P43405 (UniProtKB)
TAS
GO:0004716
P43405 (UniProtKB)
IEA
GO:0005178
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005524
P43405 (UniProtKB)
IEA
GO:0005634
P43405 (UniProtKB)
IDA
GO:0005737
P43405 (UniProtKB)
IDA
GO:0005829
P43405 (UniProtKB)
IC
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005886
P43405 (UniProtKB)
TAS
GO:0005886
P43405 (UniProtKB)
TAS
GO:0005886
P43405 (UniProtKB)
TAS
GO:0005886
P43405 (UniProtKB)
TAS
GO:0005886
P43405 (UniProtKB)
TAS
GO:0005886
P43405 (UniProtKB)
TAS
GO:0005886
P43405 (UniProtKB)
TAS
GO:0006468
P43405 (UniProtKB)
ISS
GO:0006468
P43405 (UniProtKB)
IDA
GO:0006954
P43405 (UniProtKB)
IBA
GO:0007159
P43405 (UniProtKB)
IDA
GO:0007169
P43405 (UniProtKB)
IBA
GO:0007229
P43405 (UniProtKB)
ISS
GO:0007229
P43405 (UniProtKB)
NAS
GO:0007257
P43405 (UniProtKB)
IEA
GO:0008283
P43405 (UniProtKB)
TAS
GO:0009887
P43405 (UniProtKB)
TAS
GO:0010543
P43405 (UniProtKB)
ISS
GO:0010803
P43405 (UniProtKB)
IMP
GO:0016032
P43405 (UniProtKB)
IEA
GO:0018105
P43405 (UniProtKB)
IEA
GO:0019370
P43405 (UniProtKB)
IEA
GO:0019815
P43405 (UniProtKB)
IEA
GO:0019901
P43405 (UniProtKB)
IEA
GO:0030168
P43405 (UniProtKB)
TAS
GO:0030593
P43405 (UniProtKB)
IDA
GO:0031234
P43405 (UniProtKB)
IBA
GO:0031623
P43405 (UniProtKB)
ISS
GO:0032009
P43405 (UniProtKB)
ISS
GO:0032481
P43405 (UniProtKB)
IEA
GO:0032928
P43405 (UniProtKB)
ISS
GO:0033630
P43405 (UniProtKB)
ISS
GO:0033630
P43405 (UniProtKB)
IBA
GO:0038083
P43405 (UniProtKB)
IBA
GO:0038095
P43405 (UniProtKB)
TAS
GO:0038096
P43405 (UniProtKB)
TAS
GO:0042101
P43405 (UniProtKB)
IDA
GO:0042742
P43405 (UniProtKB)
ISS
GO:0042991
P43405 (UniProtKB)
IMP
GO:0043234
P43405 (UniProtKB)
IDA
GO:0043306
P43405 (UniProtKB)
IBA
GO:0043313
P43405 (UniProtKB)
ISS
GO:0043366
P43405 (UniProtKB)
IEA
GO:0045087
P43405 (UniProtKB)
ISS
GO:0045087
P43405 (UniProtKB)
IBA
GO:0045401
P43405 (UniProtKB)
IEA
GO:0045425
P43405 (UniProtKB)
IEA
GO:0045579
P43405 (UniProtKB)
IMP
GO:0045588
P43405 (UniProtKB)
IEA
GO:0045780
P43405 (UniProtKB)
ISS
GO:0046638
P43405 (UniProtKB)
IEA
GO:0046641
P43405 (UniProtKB)
IBA
GO:0048514
P43405 (UniProtKB)
ISS
GO:0050715
P43405 (UniProtKB)
IEA
GO:0050731
P43405 (UniProtKB)
IEA
GO:0050764
P43405 (UniProtKB)
ISS
GO:0050850
P43405 (UniProtKB)
IEA
GO:0050853
P43405 (UniProtKB)
ISS
GO:0050853
P43405 (UniProtKB)
IBA
GO:0051090
P43405 (UniProtKB)
IMP
GO:0070372
P43405 (UniProtKB)
ISS
GO:0071226
P43405 (UniProtKB)
ISS
GO:0071404
P43405 (UniProtKB)
ISS
GO:0090237
P43405 (UniProtKB)
ISS
GO:0090330
P43405 (UniProtKB)
ISS
GO:0090330
P43405 (UniProtKB)
IBA

Related microRNA

Related microRNA

microRNAs potentially regulating SYK:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
melanoma 0.125991584 3 0 BeFree_CTD_human_LHGDN
Multiple Sclerosis 0.122367032 1 1 GAD_GWASCAT
Dementia, Vascular 0.120271442 1 1 BeFree_GWASCAT
Mesothelioma 0.12 1 0 CTD_human
Anti-Glomerular Basement Membrane Disease 0.08 1 0 RGD
Neoplasm Metastasis 0.010073144 9 0 BeFree_LHGDN
Mammary Neoplasms 0.009258818 7 0 BeFree_LHGDN
Lymphoma 0.00680591 7 0 BeFree_LHGDN
Peripheral T-Cell Lymphoma 0.004624443 8 0 BeFree_LHGDN
leukemia 0.003538676 3 0 BeFree_LHGDN

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