TRIM69Gene Detail-Gene Database-Genelibs

TRIM69 (tripartite motif containing 69)

symbol

TRIM69

locus group

protein-coding gene

location

15q15-q21

gene_family

Ring finger proteins|Tripartite motif-containing

alias symbol

Trif|TRIMLESS

alias name

None

entrez id

140691

ensembl gene id

ENSG00000185880

ucsc gene id

uc001zuf.3

refseq accession

NM_001301144

hgnc_id

HGNC:17857

approved reserved

2002-01-10

15q15-q21

ChineseEnglish

TRIM69（Tripartite Motif Containing 69）属于TRIM基因家族，这是一个在进化上高度保守的蛋白质家族，其成员通常包含三个保守的结构域：RING结构域、B-box结构域和卷曲螺旋结构域。TRIM家族蛋白广泛参与多种细胞过程，包括先天免疫、细胞增殖、凋亡调控和抗病毒防御。TRIM69作为一种E3泛素连接酶，主要通过泛素-蛋白酶体系统参与蛋白质的翻译后修饰，调控靶蛋白的稳定性或功能。研究表明，TRIM69在睾丸组织中高表达，可能参与精子发生过程，并在生殖系统中发挥重要作用。此外，TRIM69还被发现可以抑制某些病毒的复制，如乙型肝炎病毒（HBV），这表明它在抗病毒免疫中具有一定功能。TRIM69的突变可能导致其E3泛素连接酶活性丧失，进而影响其对靶蛋白的调控能力，可能与男性不育或病毒感染易感性增加相关。当TRIM69过表达时，可能增强其对病毒复制的抑制作用，但过度活跃的泛素化也可能导致某些重要蛋白被异常降解，干扰正常细胞功能。相反，TRIM69表达降低可能削弱机体的抗病毒防御能力，并可能影响精子发生过程。TRIM家族成员的共性在于它们大多具有E3泛素连接酶活性，通过泛素化修饰参与多种信号通路的调控，并在免疫反应、细胞周期调控和肿瘤发生中发挥重要作用。TRIM69作为该家族的一员，其功能特点既体现了TRIM家族的共性，又在生殖系统和抗病毒免疫中展现出独特的作用。

该基??因编码的RING-B框-卷曲螺旋（RBCC）家族的成员，编码的蛋白质与N-末端RING指基序，一个PRY结构域和C-末端SPRY域。该基因的小鼠直向同源物是专门在生殖细胞在精子发生过程中的圆精子细胞阶段，过表达时表达，诱导细胞凋亡。编码不同同种型的可变剪接转录物变体已有描述。 [由RefSeq的，2008年7月提供]

This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

OMIM entry for TRIM69 Wikipedia entry for TRIM69

Nucleotide sequence of TRIM69:[NCBI]

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Protein Sequence

1MEVSTNPSSN IDPGDYVEMN DSITHLPSKV VIQDITMELH
41CPLCNDWFRD PLMLSCGHNF CEACIQDFWR LQAKETFCPE
81
CKMLCQYNN CTFNPVLDKL VEKIKKLPLL KGHPQCPEHG
121ENLKLFSKPD GKLICFQCKD ARLSVGQSKE FLQISDAVHF
161F
TEELAIQQ GQLETTLKEL QTLRNMQKEA IAAHKENKLH
201LQQHVSMEFL KLHQFLHSKE KDILTELREE GKALNEEMEL
241NL
SQLQEQC LLAKDMLVSI QAKTEQQNSF DFLKDITTLL
281HSLEQGMKVL ATRELISRKL NLGQYKGPIQ YMVWREMQDT
321LCP
GLSPLT LDPKTAHPNL VLSKSQTSVW HGDIKKIMPD
361DPERFDSSVA VLGSRGFTSG KWYWEVEVAK KTKWTVGVVR
401ESII
RKGSC PLTPEQGFWL LRLRNQTDLK ALDLPSFSLT
441LTNNLDKVGI YLDYEGGQLS FYNAKTMTHI YTFSNTFMEK
481LYPYF
CPCL NDGGENKEPL HILHPQ

Structure predicted by AlphaFold DB(UniProt: Q86WT6). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

SNP variants of TRIM69: Showing partial SNPs

rs935888 rs935888 rs935889 rs935889 rs1901534 rs1901534 rs1901535 rs1901535 rs1901536 rs1901536 rs1901537 rs1901537 rs1901538 rs1901538 rs2084835 rs2084835 rs2123149

Tissue expression of TRIM69: [UniProt]

Forward Primer

Forward Tm

Reverse Primer

Reverse Tm

Score

GAATAACTACCGGGCAGGA

58

GAGTGGATCTTCTGGGAGC

59

TGAGCATTCAGGCAAAGAC

58

CTTGCTCCAAGCTATGTAAGAG

59

CAAATAGTCGAGAATAGCGATCC

59

TTGATCATCATTTGCGAGATGG

59

CTTACATAGCTTGGAGCAAGG

58

TAGGACCTTTGTACTGGCC

58

GAATCTGAGCCAGCTTCAG

58

CTTGCTCCAAGCTATGTAAGAG

59

ATAGTCGAGAATAGCGATCCG

59

CTGGACTAAGGATGCTCGA

58

AATAACTACCGGGCAGGAC

59

GGAGTGGATCTTCTGGGAG

58

GAGCATTCAGGCAAAGACG

59

CTTGCTCCAAGCTATGTAAGAG

59

GAATCTGAGCCAGCTTCAG

58

TTGCTCCAAGCTATGTAAGAG

57

GCAAATAGTCGAGAATAGCGA

58

GATCATCATTTGCGAGATGGT

58

Subcellular localization of TRIM69 (and its protein):

[UniProt] [GenomeNet]

plasma membrane
cytoplasm
extracellular
golgi
vesicle
cytoskeleton
endoplasmic reticulum
nucleus
endosome
lysosome
mitochondrion

Gene Ontology (GO) terms for TRIM69:

GO ID

Protein

Source DB

GO:0005622

A0A0G2JPI4 (UniProtKB)

IEA

GO:0008270

A0A0G2JPI4 (UniProtKB)

IEA

GO:0005634

H0YL66 (UniProtKB)

IDA

GO:0005730

H0YL66 (UniProtKB)

IDA

GO:0005794

H0YL66 (UniProtKB)

IDA

GO:0005886

H0YL66 (UniProtKB)

IDA

GO:0043231

H0YL66 (UniProtKB)

IDA

GO:0000209

Q86WT6 (UniProtKB)

TAS

GO:0004842

Q86WT6 (UniProtKB)

EXP

GO:0004842

Q86WT6 (UniProtKB)

IDA

GO:0004842

Q86WT6 (UniProtKB)

TAS

GO:0005515

Q86WT6 (UniProtKB)

IPI

GO:0005515

Q86WT6 (UniProtKB)

IPI

GO:0005515

Q86WT6 (UniProtKB)

IPI

GO:0005515

Q86WT6 (UniProtKB)

IPI

GO:0005515

Q86WT6 (UniProtKB)

IPI

GO:0005515

Q86WT6 (UniProtKB)

IPI

GO:0005515

Q86WT6 (UniProtKB)

IPI

GO:0005515

Q86WT6 (UniProtKB)

IPI

GO:0005515

Q86WT6 (UniProtKB)

IPI

GO:0005515

Q86WT6 (UniProtKB)

IPI

GO:0005515

Q86WT6 (UniProtKB)

IPI

GO:0005515

Q86WT6 (UniProtKB)

IPI

GO:0005515

Q86WT6 (UniProtKB)

IPI

GO:0005515

Q86WT6 (UniProtKB)

IPI

GO:0005515

Q86WT6 (UniProtKB)

IPI

GO:0005515

Q86WT6 (UniProtKB)

IPI

GO:0005515

Q86WT6 (UniProtKB)

IPI

GO:0005515

Q86WT6 (UniProtKB)

IPI

GO:0005515

Q86WT6 (UniProtKB)

IPI

GO:0005634

Q86WT6 (UniProtKB)

IDA

GO:0005737

Q86WT6 (UniProtKB)

IDA

GO:0005737

Q86WT6 (UniProtKB)

IDA

GO:0005829

Q86WT6 (UniProtKB)

TAS

GO:0005829

Q86WT6 (UniProtKB)

TAS

GO:0005829

Q86WT6 (UniProtKB)

TAS

GO:0005829

Q86WT6 (UniProtKB)

TAS

GO:0005886

Q86WT6 (UniProtKB)

IDA

GO:0006915

Q86WT6 (UniProtKB)

IEA

GO:0008270

Q86WT6 (UniProtKB)

IEA

GO:0016607

Q86WT6 (UniProtKB)

IDA

GO:0016874

Q86WT6 (UniProtKB)

IEA

microRNAs potentially regulating TRIM69:

hsa-miR-335 hsa-miR-147

String

BioGrid

IntAct

mentha

MINT

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Interacting Gene	Interaction	Source/Score

Disease

Score

NofPmids

NofSnps

Source

Disease	Score	NofPmids	NofSnps	Source
Narcolepsy	0.002367032	1	0	GAD
Tobacco Use Disorder	0.002367032	1	0	GAD
Herpes encephalitis	0.000542884	2	0	BeFree
Virus Diseases	0.000542884	2	0	BeFree
Herpes Simplex Infections	0.000542884	2	0	BeFree
Influenza	0.000542884	2	0	BeFree
Respiratory Syncytial Virus Infections	0.000542884	2	0	BeFree
Intraocular Infection	0.000271442	1	0	BeFree
Malignant neoplasm of pancreas	0.000271442	1	0	BeFree
Sepsis	0.000271442	1	0	BeFree

Transcriptomic and bioinformatics analysis reveals the host response feature and potential treatment strategy of patients with dengue fever.

Liu C, Yu X, Chen J, Zhong M, Ye B, Wang K, Jiang Y, Li G, Zhan S Front Immunol IF: 7.0 None

Increased expression of TRIM69 in peripheral blood from systemic lupus erythematosus and its clinical significance.

Zhan J, Tu C, Su R, Luo Q, Huang Z, Long D, Li J Clin Exp Rheumatol IF: 3.2 2026-07-00

TRIM69 potentiates the cGAS-STING signalling pathway by promoting STING ubiquitination.

Chen S, Yi L, Xue M, Zheng C Cell Signal IF: 4.7 2026-07-00

Transcriptomic Analysis Reveals Novel Mechanisms Underlying Neutrophil Activation Induced by High Salt.

Mazzitelli I, Bleichmar L, Rivelli F, Feijoo I, Adamczyk A, Cabrerizo G, Erra Díaz F, Geffner J Int J Mol Sci IF: 3.226 2026-01-21

Microtubule remodeling by the innate immune factor Trim69 compromises dynein-dependent migration of HIV virion cores toward the nucleus.

Vadon C, Nguyen XN, Siahaan V, Song Y, Krishnan A, Henriot V, Chantharath A, Burlaud-Gaillard J, Roingeard P, Janke C, Etienne L, Fiorini F, Magiera MM, Cimarelli A Proc Natl Acad Sci U S A IF: 9.5 2025-10-14

Tripartite motif containing 69 elicits ERK2-dependent EYA4 turnover to impart pancreatic tumorigenesis.

Jia Y, Li HY, Wang J, Chen X, Lou L, Wei YY, Wang Y, Mo SJ J Cancer IF: 3.4 2023-00-00

TRIM69: a marker of metastasis and potential sensitizer to 5-Fluorouracil and PD-1 blockers in colon adenocarcinoma.

Chi XJ, Song YB, Liu DH, Wei LQ, Zhao AR, An X, Feng ZZ, Lan XH, Lv YM, Li HJ, Lan D, He HM BMC Gastroenterol IF: 2.212 2023-08-31

Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry.

Bagga T, Tulsian NK, Mok YK, Kini RM, Sivaraman J Cell Mol Life Sci IF: 6.5 2022-04-10

Trim69 is a microtubule regulator that acts as a pantropic viral inhibitor.

Song Y, Nguyen XN, Kumar A, da Silva C, Picard L, Etienne L, Cimarelli A Proc Natl Acad Sci U S A IF: 9.5 2022-00-25

HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by diminishing Trim69-dependent FSP1 degradation in hepatocellular carcinoma.

Yuan J, Lv T, Yang J, Wu Z, Yan L, Yang J, Shi Y Redox Biol IF: 16.2 2022-00-00

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TRIM69 (tripartite motif containing 69)

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Gene Summary

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