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Transcriptomic and bioinformatics analysis reveals the host response feature an…

Liu(C),Yu(X),Chen(J),Zhong(M),Ye(B),Wang(K),… Front Immunol None

...TRIM69. Then we estimated the relative proportion of 22 immune cell types and their correlation with signature genes. Th...

Increased expression of TRIM69 in peripheral blood from systemic lupus erythema…

Zhan(J),Tu(C),Su(R),Luo(Q),Huang(Z),Long(D),… Clin Exp Rheumatol 2026-07-00

...TRIM69 mRNA expression in whole blood was measured by RT‑qPCR; serum TRIM69 levels were detected by ELISA. Clinical corr...

TRIM69 potentiates the cGAS-STING signalling pathway by promoting STING ubiquit…

Chen(S),Yi(L),Xue(M),Zheng(C) Cell Signal 2026-07-00

...TRIM69 and STING is essential for the ability of TRIM69 to activate the K63-linked ubiquitination of STING, which result...

Transcriptomic Analysis Reveals Novel Mechanisms Underlying Neutrophil Activati…

Mazzitelli(I),Bleichmar(L),Rivelli(F),Feijoo… Int J Mol Sci 2026-01-21

...TRIM69), amphiregulin (AREG), oncostatin (OSM), and transducer of ERBB2-1 (TOB1), suggesting a broader role for neutroph...

Microtubule remodeling by the innate immune factor Trim69 compromises dynein-de…

Vadon(C),Nguyen(XN),Siahaan(V),Song(Y),Krish… Proc Natl Acad Sci U S A 2025-10-14

...Trim69s and is critical for its functions. We demonstrate that by binding and remodeling MTs, Trim69 inhibits the dockin...

Tripartite motif containing 69 elicits ERK2-dependent EYA4 turnover to impart p…

Jia(Y),Li(HY),Wang(J),Chen(X),Lou(L),Wei(YY)… J Cancer 2023-00-00

...TRIM69) with EYA4 in human PDAC. TRIM69 elicits EYA4 polyubiquitylation and turnover independent of P53 and impedes the ...

TRIM69: a marker of metastasis and potential sensitizer to 5-Fluorouracil and P…

Chi(XJ),Song(YB),Liu(DH),Wei(LQ),Zhao(AR),An… BMC Gastroenterol 2023-08-31

...TRIM69 was lacking. The present study examined the correlation between TRIM69 expression and colon adenocarcinoma (COAD)...

The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome seg…

Wang(Y),Risteski(P),Yang(Y),Chen(H),Droby(G)… Nucleic Acids Res 2023-00-27

...TRIM69. TRIM69-ablation in cancer cells leads to centrosome scattering and chromosome segregation defects. We identify S...

TRIM69 suppressed the anoikis resistance and metastasis of gastric cancer throu…

Sun(L),Chen(Y),Xia(L),Wang(J),Zhu(J),Li(J),W… Oncogene 2023-00-00

...TRIM69 and PRKCD was analyzed by coimmunoprecipitation and mass spectrometry. Our results have shown that TRIM69 was sig...

Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue vir…

Bagga(T),Tulsian(NK),Mok(YK),Kini(RM),Sivara… Cell Mol Life Sci 2022-04-10

...TRIM69 interacting with the Dengue viral protein. Collectively, our findings suggest that TRIM69 may act as a pan-antifl...

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