ZFX (zinc finger protein X-linked)

Gene Basic Information

Gene Basic Information

symbol
ZFX
locus group
protein-coding gene
location
Xp22.11
gene_family
Zinc fingers, C2H2-type
alias symbol
ZNF926
alias name
None
entrez id
7543
ensembl gene id
ENSG00000005889
ucsc gene id
uc004dbd.3
refseq accession
NM_003410
hgnc_id
HGNC:12869
approved reserved
1988-07-06

Chromosome Location

Chromosome Location

Xp22.11

Gene Summary

Gene Summary

ChineseEnglish

This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]

OMIM entry for ZFX     Wikipedia entry for ZFX

Gene Sequence

Gene Sequence

Nucleotide sequence of ZFX:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MDEDGLELQQ EPNSFFDATG ADGTHMDGDQ IVVEVQETVF
41VSDVVDSDIT VHNFVPDDPD SVVIQDVIED VVIEDVQCPD
81 IMEEADVSE TVIIPEQVLD SDVTEEVSLA HCTVPDDVLA
121SDITSASMSM PEHVLTGDSI HVSDVGHVGH VGHVEHVVHD
161S VVEAEIVT DPLTTDVVSE EVLVADCASE AVIDANGIPV
201DQQDDDKGNC EDYLMISLDD AGKIEHDGSS GMTMDTESEI
241DP CKVDGTC PEVIKVYIFK ADPGEDDLGG TVDIVESEPE
281NDHGVELLDQ NSSIRVPREK MVYMTVNDSQ PEDEDLNVAE
321IAD EVYMEV IVGEEDAAAA AAAAAVHEQQ MDDNEIKTFM
361PIAWAAAYGN NSDGIENRNG TASALLHIDE SAGLGRLAKQ
401KPKK RRRPD SRQYQTAIII GPDGHPLTVY PCMICGKKFK
441SRGFLKRHMK NHPEHLAKKK YRCTDCDYTT NKKISLHNHL
481ESHKL TSKA EKAIECDECG KHFSHAGALF THKMVHKEKG
521ANKMHKCKFC EYETAEQGLL NRHLLAVHSK NFPHICVECG
561KGFRHP SEL KKHMRIHTGE KPYQCQYCEY RSADSSNLKT
601HVKTKHSKEM PFKCDICLLT FSDTKEVQQH ALIHQESKTH
641QCLHCDH KS SNSSDLKRHI ISVHTKDYPH KCDMCDKGFH
681RPSELKKHVA AHKGKKMHQC RHCDFKIADP FVLSRHILSV
721HTKDLPFR C KRCRKGFRQQ SELKKHMKTH SGRKVYQCEY
761CEYSTTDASG FKRHVISIHT KDYPHRCEYC KKGFRRPSEK
801NQHIMRHHK EVGLP
Structure predicted by AlphaFold DB(UniProt: P17010). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of ZFX:           Showing partial SNPs
rs3761639       rs3761640       rs3838208       rs6526373       rs11795835       rs34848343       rs73474140       rs78155031       rs112380861       rs113207918       rs139447985       rs140372953       rs142707879       rs181789028       rs182414125       rs184087956       rs184894370      

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TTTGATGCAACAGGAGCTG
59
GCACAGTTATGTCTGAATCCA
59
ACAGTCCTGTGAGATTCAGAG
59
TTCTGGTGCAATATACCACCA
60
CTACCTTATGATTTCCTGTGGA
57
TGATCAAGCAGTTCAACTCC
58
TGATTTCCTTGGATGATGCTG
59
GATCAATTTCCGACTCTGTGTC
60
CATAGATGAGTCTGCTGGC
58
CAGGGCCAATAATTATTGCTG
58
ATGCAACAGACAGGGTCTC
60
AGCAGATCACTTGAGCCTG
60
TGACTTAGGTGGAACTGTAGAC
59
CTGCTGTTCTGATCAAGCAG
59
TGGGCTTGAATTACAACAAGAG
59
TGTGTACCATCAGCTCCTG
59
TCAGTAAACACTGGGAAAGAC
58
TGAACATCCACTGTTGCTG
58
TAAGGTGCTTTCGATGCAG
58
CTTCCTTTATTCAGATACTCGGG
59

Gene Ontology

Subcellular localization of ZFX (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for ZFX:

GO ID
Protein
Source DB
GO:0003677
C9J682 (UniProtKB)
IEA
GO:0005634
C9J682 (UniProtKB)
IEA
GO:0006355
C9J682 (UniProtKB)
IEA
GO:0046872
C9J682 (UniProtKB)
IEA
GO:0003677
E9PEP7 (UniProtKB)
IEA
GO:0005634
E9PEP7 (UniProtKB)
IEA
GO:0006355
E9PEP7 (UniProtKB)
IEA
GO:0046872
E9PEP7 (UniProtKB)
IEA
GO:0000977
P17010 (UniProtKB)
IBA
GO:0003677
P17010 (UniProtKB)
TAS
GO:0003700
P17010 (UniProtKB)
IBA
GO:0003713
P17010 (UniProtKB)
TAS
GO:0005634
P17010 (UniProtKB)
IEA
GO:0006351
P17010 (UniProtKB)
IEA
GO:0006355
P17010 (UniProtKB)
IBA
GO:0007275
P17010 (UniProtKB)
IBA
GO:0046872
P17010 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating ZFX:     

Gene Interactions

Gene Interactions

String
IntAct
mentha
Loading…
Interacting Gene Interaction Source/Score

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Carcinogenesis 0.001085767 4 0 BeFree
Malignant neoplasm of stomach 0.000814326 3 0 BeFree
Glioma 0.000814326 3 0 BeFree
Stomach Carcinoma 0.000814326 3 0 BeFree
Non-Small Cell Lung Carcinoma 0.000814326 3 0 BeFree
Secondary malignant neoplasm of lymph node 0.000542884 2 0 BeFree
Laryngeal Squamous Cell Carcinoma 0.000542884 2 0 BeFree
Malignant neoplasm of gallbladder 0.000542884 2 0 BeFree
Squamous cell carcinoma of tongue 0.000542884 2 0 BeFree
Gallbladder Carcinoma 0.000542884 2 0 BeFree

Related Publications

Related Publications

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The Y Chromosome is a Reliable Marker for Deep-Time Phylogenetic Inference.
Alexander EP, Foley NM, Murphy WJ Syst Biol IF: 6.2 2026-07-22
Systematic identification of single transcription factor perturbations that drive cellular and tissue rejuvenation.
Sengstack J, Zheng J, Aghayev T, Bieri G, Mobaraki M, Lin J, Deng C, Villeda SA, Li H Proc Natl Acad Sci U S A IF: 9.5 2026-01-13
Species delimitation based on phylogenetic analyses of males: A case study revealing the complex evolutionary history of giraffes.
Hassanin A, Jullemier E, Chardonnet B, Robinson TJ Mol Phylogenet Evol IF: 4.0 2026-05-00
De Novo Heterozygous ZFX Frameshift Variant in a Female With an X-Linked Neurodevelopmental Disorder.
Showpnil IA, Daley A, Sites ER, Plourde SM, Hunter JM, Bartholomew DW, Lehman AN, Koboldt DC, Stottmann RW Am J Med Genet A IF: 1.7 2026-02-00
Tightening the Sphincter on Faecal Sample Anonymity: The Case of the Weddell Seal (Leptonychotes weddellii).
van den Hoff J, Fanson KV, Polanowski A, Wotherspoon S Zoo Biol IF: 1.5 2026-06-06
Single-cell multiomics gene regulatory landscape reveals impaired spermatogonial stem cells and macrophage-driven inflammaging during testicular aging.
Lin N, Zhang Z, Sha X, Yao J, Sun X, Sun R, Yang J, Yu Q, Wu Z, Guan J, Mo C, Ouyang B, Xie Y J Genet Genomics IF: 7.9 2026-05-20
Expansion of the phenotype in ZFX neurodevelopmental disorder in a family.
van der Tol L, de Jong M, Alders M, Wilke M, van der Schoot V, van Slegtenhorst MA, Goverde A Eur J Med Genet IF: 2.2 2025-12-00

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