LYN (LYN proto-oncogene, Src family tyrosine kinase)

基因基本信息

基因基本信息

symbol:
LYN
locus group:
protein-coding gene
location:
8q12.1
gene_family:
SH2 domain containing
alias symbol:
JTK8
alias name:
None
entrez id:
4067
ensembl gene id:
ENSG00000254087
ucsc gene id:
uc003xsk.5
refseq accession:
NM_002350
hgnc_id:
HGNC:6735
approved reserved:
1986-01-01

基因染色体位置

基因染色体位置

8q12.1

基因简述

基因简述

LYN是一种属于Src家族激酶（SFK）的非受体酪氨酸激酶基因，在免疫细胞信号传导中发挥核心作用。该基因位于人类8号染色体（8q12.1），编码的Lyn蛋白具有典型的Src家族结构特征：N端肉豆蔻酰化位点、独特结构域、SH3和SH2蛋白相互作用域以及C端的激酶活性域。作为B细胞受体（BCR）信号通路的关键调节者，Lyn通过磷酸化免疫受体酪氨酸激活基序（ITAM）启动下游信号，同时也能通过磷酸化抑制性受体（如CD22和FcγRIIB）的ITIM基序来负向调控信号。在肥大细胞中，Lyn参与FcεRI受体介导的过敏反应信号传导。该基因突变可导致功能获得或功能丧失，功能获得性突变与某些白血病相关，而功能缺失则与自身免疫疾病如系统性红斑狼疮有关。Lyn表达异常会影响多种细胞过程：过表达可能促进肿瘤发生，特别是在慢性淋巴细胞白血病（CLL）和急性髓系白血病（AML）中观察到其异常激活；而表达降低会导致B细胞过度活化，与自身抗体产生相关。在Src家族中，Lyn与Blk、Fyn等成员共享通过脂修饰锚定在细胞膜内侧的特性，都能通过酪氨酸磷酸化调控下游信号。这个家族的特征是都具有调节细胞增殖、分化、存活和迁移的酪氨酸激酶活性，且其活性受C端抑制性酪氨酸（Y507）和激活环酪氨酸（Y396）磷酸化状态的动态平衡控制。最新研究发现Lyn还参与神经退行性疾病如阿尔茨海默病的病理过程，可能通过调节小胶质细胞活性影响神经炎症。针对Lyn的抑制剂如达沙替尼已被开发用于癌症治疗，但需注意其对正常免疫功能的影响。

中文English

这个基因编码酪氨酸蛋白激酶，这可能涉及在肥大细胞脱粒，和红细胞分化的调节。已发现该基因编码不同亚型选择性剪接转录变异体。 [由RefSeq的，2011年7月提供]

OMIM数据库中对LYN基因的介绍     Wikipedia数据库中对LYN基因的介绍

基因序列

基因序列

LYN基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MGCIKSKGKD SLSDDGVDLK TQPVRNTERT IYVRDPTSNK
41QQRPVPESQL LPGQRFQTKD PEEQGDIVVA LYPYDGIHPD
81 DLSFKKGEK MKVLEEHGEW WKAKSLLTKK EGFIPSNYVA
121KLNTLETEEW FFKDITRKDA ERQLLAPGNS AGAFLIRESE
161T LKGSFSLS VRDFDPVHGD VIKHYKIRSL DNGGYYISPR
201ITFPCISDMI KHYQKQADGL CRRLEKACIS PKPQKPWDKD
241AW EIPRESI KLVKRLGAGQ FGEVWMGYYN NSTKVAVKTL
281KPGTMSVQAF LEEANLMKTL QHDKLVRLYA VVTREEPIYI
321ITE YMAKGS LLDFLKSDEG GKVLLPKLID FSAQIAEGMA
361YIERKNYIHR DLRAANVLVS ESLMCKIADF GLARVIEDNE
401YTAR EGAKF PIKWTAPEAI NFGCFTIKSD VWSFGILLYE
441IVTYGKIPYP GRTNADVMTA LSQGYRMPRV ENCPDELYDI
481MKMCW KEKA EERPTFDYLQ SVLDDFYTAT EGQYQQQP
结构预测来自 AlphaFold DB（UniProt: P07948），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

LYN基因的碱基突变：           仅显示部分snp
rs13636       rs167999       rs182832       rs182833       rs333612       rs333614       rs333615       rs333616       rs333617       rs333618       rs333619       rs867586       rs868541       rs907422       rs907423       rs907424       rs907425      

基因表达

基因表达

LYN基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CCAACGTCCAATAAACAGCA
59
CCTCTGGATCTTTAGTTTGAAACC
59
TCTGCTCAGATTGCAGAGG
59
CCAGAACATTAGCTGCTCG
58
TCTGCTCAGATTGCAGAGG
59
CAGAACATTAGCTGCTCGC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

LYN基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

LYN基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0001782
P07948 (UniProtKB)
ISS
GO:0001817
P07948 (UniProtKB)
ISS
GO:0001932
P07948 (UniProtKB)
TAS
GO:0001933
P07948 (UniProtKB)
ISS
GO:0002223
P07948 (UniProtKB)
TAS
GO:0002250
P07948 (UniProtKB)
IEA
GO:0002431
P07948 (UniProtKB)
ISS
GO:0002431
P07948 (UniProtKB)
IBA
GO:0002513
P07948 (UniProtKB)
ISS
GO:0002513
P07948 (UniProtKB)
TAS
GO:0002553
P07948 (UniProtKB)
IEA
GO:0002576
P07948 (UniProtKB)
ISS
GO:0002576
P07948 (UniProtKB)
IBA
GO:0002762
P07948 (UniProtKB)
IEA
GO:0002768
P07948 (UniProtKB)
ISS
GO:0002768
P07948 (UniProtKB)
TAS
GO:0002774
P07948 (UniProtKB)
ISS
GO:0002902
P07948 (UniProtKB)
IBA
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
IDA
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
TAS
GO:0004713
P07948 (UniProtKB)
TAS
GO:0004713
P07948 (UniProtKB)
TAS
GO:0004713
P07948 (UniProtKB)
TAS
GO:0004713
P07948 (UniProtKB)
TAS
GO:0004713
P07948 (UniProtKB)
TAS
GO:0004715
P07948 (UniProtKB)
IBA
GO:0004715
P07948 (UniProtKB)
TAS
GO:0004716
P07948 (UniProtKB)
TAS
GO:0005102
P07948 (UniProtKB)
IBA
GO:0005161
P07948 (UniProtKB)
IEA
GO:0005178
P07948 (UniProtKB)
IEA
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005524
P07948 (UniProtKB)
IEA
GO:0005634
P07948 (UniProtKB)
ISS
GO:0005634
P07948 (UniProtKB)
IDA
GO:0005737
P07948 (UniProtKB)
ISS
GO:0005758
P07948 (UniProtKB)
IEA
GO:0005794
P07948 (UniProtKB)
IDA
GO:0005794
P07948 (UniProtKB)
IDA
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
IDA
GO:0005886
P07948 (UniProtKB)
IDA
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005913
P07948 (UniProtKB)
IEA
GO:0006468
P07948 (UniProtKB)
IDA
GO:0006954
P07948 (UniProtKB)
IBA
GO:0006974
P07948 (UniProtKB)
IDA
GO:0006974
P07948 (UniProtKB)
IDA
GO:0006991
P07948 (UniProtKB)
IEA
GO:0007165
P07948 (UniProtKB)
TAS
GO:0007169
P07948 (UniProtKB)
IMP
GO:0007417
P07948 (UniProtKB)
IBA
GO:0007596
P07948 (UniProtKB)
TAS
GO:0008284
P07948 (UniProtKB)
ISS
GO:0008285
P07948 (UniProtKB)
IMP
GO:0009636
P07948 (UniProtKB)
IEA
GO:0009725
P07948 (UniProtKB)
ISS
GO:0009743
P07948 (UniProtKB)
IEA
GO:0010976
P07948 (UniProtKB)
IMP
GO:0014003
P07948 (UniProtKB)
IEA
GO:0014069
P07948 (UniProtKB)
IEA
GO:0014070
P07948 (UniProtKB)
IEA
GO:0016032
P07948 (UniProtKB)
IEA
GO:0017124
P07948 (UniProtKB)
IEA
GO:0018108
P07948 (UniProtKB)
IDA
GO:0019899
P07948 (UniProtKB)
IPI
GO:0019899
P07948 (UniProtKB)
IPI
GO:0023014
P07948 (UniProtKB)
IEA
GO:0030061
P07948 (UniProtKB)
IEA
GO:0030168
P07948 (UniProtKB)
TAS
GO:0030218
P07948 (UniProtKB)
ISS
GO:0030335
P07948 (UniProtKB)
IEA
GO:0030889
P07948 (UniProtKB)
IBA
GO:0031175
P07948 (UniProtKB)
IEA
GO:0031234
P07948 (UniProtKB)
IBA
GO:0031295
P07948 (UniProtKB)
TAS
GO:0031295
P07948 (UniProtKB)
TAS
GO:0031625
P07948 (UniProtKB)
IEA
GO:0031663
P07948 (UniProtKB)
ISS
GO:0031668
P07948 (UniProtKB)
IEA
GO:0032868
P07948 (UniProtKB)
IEA
GO:0033003
P07948 (UniProtKB)
ISS
GO:0033628
P07948 (UniProtKB)
IMP
GO:0034136
P07948 (UniProtKB)
ISS
GO:0034144
P07948 (UniProtKB)
ISS
GO:0034605
P07948 (UniProtKB)
IEA
GO:0034666
P07948 (UniProtKB)
IEA
GO:0038083
P07948 (UniProtKB)
IBA
GO:0038095
P07948 (UniProtKB)
TAS
GO:0038096
P07948 (UniProtKB)
TAS
GO:0042493
P07948 (UniProtKB)
IEA
GO:0042531
P07948 (UniProtKB)
ISS
GO:0042629
P07948 (UniProtKB)
IEA
GO:0043015
P07948 (UniProtKB)
IEA
GO:0043200
P07948 (UniProtKB)
IEA
GO:0043208
P07948 (UniProtKB)
IEA
GO:0043304
P07948 (UniProtKB)
ISS
GO:0043304
P07948 (UniProtKB)
IBA
GO:0043407
P07948 (UniProtKB)
ISS
GO:0043552
P07948 (UniProtKB)
IEA
GO:0044325
P07948 (UniProtKB)
IPI
GO:0044325
P07948 (UniProtKB)
IPI
GO:0045087
P07948 (UniProtKB)
IBA
GO:0045121
P07948 (UniProtKB)
IDA
GO:0045646
P07948 (UniProtKB)
ISS
GO:0046777
P07948 (UniProtKB)
IDA
GO:0048013
P07948 (UniProtKB)
TAS
GO:0048471
P07948 (UniProtKB)
IDA
GO:0048678
P07948 (UniProtKB)
IEA
GO:0050663
P07948 (UniProtKB)
IEA
GO:0050707
P07948 (UniProtKB)
IEA
GO:0050727
P07948 (UniProtKB)
IEA
GO:0050777
P07948 (UniProtKB)
TAS
GO:0050853
P07948 (UniProtKB)
IEA
GO:0050855
P07948 (UniProtKB)
ISS
GO:0050855
P07948 (UniProtKB)
IBA
GO:0050861
P07948 (UniProtKB)
IEA
GO:0050900
P07948 (UniProtKB)
TAS
GO:0051219
P07948 (UniProtKB)
IEA
GO:0051272
P07948 (UniProtKB)
IDA
GO:0051279
P07948 (UniProtKB)
IEA
GO:0051279
P07948 (UniProtKB)
IEA
GO:0060252
P07948 (UniProtKB)
IEA
GO:0060369
P07948 (UniProtKB)
IEA
GO:0060397
P07948 (UniProtKB)
TAS
GO:0070062
P07948 (UniProtKB)
IDA
GO:0070062
P07948 (UniProtKB)
IDA
GO:0070304
P07948 (UniProtKB)
IDA
GO:0070372
P07948 (UniProtKB)
ISS
GO:0070373
P07948 (UniProtKB)
ISS
GO:0070447
P07948 (UniProtKB)
IEA
GO:0070667
P07948 (UniProtKB)
ISS
GO:0070667
P07948 (UniProtKB)
IBA
GO:0070668
P07948 (UniProtKB)
IMP
GO:0071300
P07948 (UniProtKB)
IMP
GO:0090025
P07948 (UniProtKB)
IMP
GO:0090330
P07948 (UniProtKB)
ISS
GO:0090330
P07948 (UniProtKB)
IBA
GO:0097028
P07948 (UniProtKB)
ISS
GO:0097028
P07948 (UniProtKB)
IBA
GO:1902532
P07948 (UniProtKB)
ISS
GO:2000670
P07948 (UniProtKB)
ISS
GO:2000670
P07948 (UniProtKB)
IBA

基因相关microRNA

基因相关microRNA

可能调控 LYN基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

BioGrid
IntAct
mentha
MINT
Reactome
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关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
HIV Infections 0.122367032 2 0 CTD_human_GAD
Lupus Erythematosus, Systemic 0.087729856 3 0 BeFree_GAD_LHGDN_MGD
Parkinsonian Disorders 0.08 1 0 RGD
Endometriosis 0.08 1 0 RGD
Cardiomegaly 0.08 1 0 RGD
Lymphoma 0.008444493 4 0 BeFree_LHGDN
Myeloid Leukemia, Chronic 0.003810118 4 0 BeFree_LHGDN
Lymphoid leukemia 0.00272435 1 0 LHGDN
B-Cell Lymphomas 0.00272435 1 0 LHGDN
Malignant Mixed Tumor 0.00272435 1 0 LHGDN

基因相关文献

基因相关文献

PDZK1-ULK1 Axis Triggers Lipophagy to Inhibit Tumor Progression and Sunitinib Resistance in Clear Cell Renal Cell Carcinoma.
Qi X, Guo Y, Yang Y, Wang H, Yang X, Song R, Qin Q, Zhang Y, Hu M, Zhou H, Feng D, He J Adv Sci (Weinh) IF: 9.034 2026-04-00
Microglial Lyn Kinase-TRPV4 axis mediates social deficits in a maternal immune activation model.
Islam R, Zhang F, Choudhary HH, Yoshida J, Thomas AJ, Sorum B, Hanafy KA J Neuroinflammation IF: 5.102 2026-02-19
Tussilagone inhibits MRGPRX2-mediated mast cell degranulation and suppresses pseudo-allergic reactions.
Yan PP, Huang TT, Attiogbe MKI, Mi YN, Cao YX Toxicol Appl Pharmacol IF: 3.6 2026-05-00
Site-Specific Phosphoproteomic Profiling of CAV1 Reveals Co-Regulatory Kinase Networks in Cancer Signaling.
Vaz CE, Suresh M, Dcunha L, Raju R, Kanekar S Int J Mol Sci IF: 3.226 2026-05-12
Immune checkpoints in a genetically engineered mouse model of spontaneous autoimmune uveitis.
Yin M, Hiam-Galvez KJ, Proekt I, Chan J, Hu Y, Lowell CA, Caspi RR, Spitzer MH, Anderson MS, DeFranco AL J Immunol IF: 4.0 2026-03-17
ULK1-driven autophagy modulation alters tumor-promoting pathways in triple-negative breast cancer.
Bal Albayrak MG, Yanar S, Korak T, Akpinar G, Kasap M Med Oncol IF: 4.7 2026-03-03
Treml4 Drives Microglial Activation via the Lyn/Syk/ERK Pathway in Sepsis-Associated Encephalopathy.
Li R, Xie J, Li Q, Ouyang Y, Zhang Q, Wang JF, Deng XM Neurochem Res IF: 4.5 2026-05-20
When less is more and when it isn't: Microglial Spi1 and the limits of what we know.
Koldamova R, Fitz NF, Lefterov I Neuron IF: 16.9 2026-08-05

基因相关服务

基因相关服务

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