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PMID: 100051 Published · ppublish English Journal Article

Modified peptidoglycan transpeptidase activity in a carbenicillin-resistant mutant of Pseudomonas aeruginosa 18s.

Antimicrobial agents and chemotherapy ·Vol. 14 ·No. 2 ·1978-08-00 ·Pages 246-51

Curtis NA, Brown C, Boxall M, Boulton MG

Abstract

A carbenicillin-resistant mutant of Pseudomonas aeruginosa 18s was found to possess peptidoglycan transpeptidase activity significantly more resistant to inhibition by benzyl penicillin, ampicillin, carbenicillin, and cephaloridine than that of the parent strain. The mutant was more resistant than the parent strain to all of the beta-lactam antibiotics tested, and 50% inhibition values for these compounds against membrane-bound model transpeptidase activity paralleled this increase. The resistance of the mutant to kanamycin, streptomycin, and chloramphenicol was unchanged.

MeSH Terms
Acyltransferases/metabolism Aminoacyltransferases Anti-Bacterial Agents/pharmacology Carbenicillin/pharmacology Kinetics Mutation Penicillin Resistance Penicillinase/metabolism Peptidoglycan Peptidyl Transferases/antagonists & inhibitors,metabolism Pseudomonas aeruginosa/drug effects,enzymology,genetics
Chemicals
Anti-Bacterial Agents Peptidoglycan Acyltransferases Aminoacyltransferases peptidoglycan transpeptidase Peptidyl Transferases Penicillinase Carbenicillin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Curtis N A
Brown C
Boxall M
Boulton M G
References (21)
21 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.14.2.246
Published
1978-08-00
Pages
246-51
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC352441
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.14.2.246 PMC Full Text View journal details
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