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PMID: 10200246 Published · ppublish English Journal Article Review

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 96 ·No. 8 ·1999-04-13 ·Pages 4240-5

Cantley LC, Neel BG

Abstract

The most recently discovered PTEN tumor suppressor gene has been found to be defective in a large number of human cancers. In addition, germ-line mutations in PTEN result in the dominantly inherited disease Cowden syndrome, which is characterized by multiple hamartomas and a high proclivity for developing cancer. A series of publications over the past year now suggest a mechanism by which PTEN loss of function results in tumors. PTEN appears to negatively control the phosphoinositide 3-kinase signaling pathway for regulation of cell growth and survival by dephosphorylating the 3 position of phosphoinositides.

MeSH Terms
Cell Division Cell Survival Genes, Tumor Suppressor Humans Neoplasms/genetics,metabolism,pathology PTEN Phosphohydrolase Phosphatidylinositol 3-Kinases/metabolism Phosphoric Monoester Hydrolases/genetics,metabolism Protein Serine-Threonine Kinases/metabolism Proto-Oncogene Proteins Proto-Oncogene Proteins c-akt Signal Transduction Tumor Suppressor Proteins
Chemicals
Proto-Oncogene Proteins Tumor Suppressor Proteins AKT1 protein, human Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-akt Phosphoric Monoester Hydrolases PTEN Phosphohydrolase PTEN protein, human
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cantley L C
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. [email protected]
Neel B G
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.96.8.4240
Email
[email protected]
Published
1999-04-13
Pages
4240-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC33561
Subset
IM
Grants
NIGMS NIH HHS · R01 GM041890 · United States
External Links
PubMed source DOI: 10.1073/pnas.96.8.4240 PMC Full Text View journal details
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