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PMID: 10393989 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Right hemispheric dominance of inhibitory control: an event-related functional MRI study.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 96 ·No. 14 ·1999-07-06 ·Pages 8301-6

Garavan H, Ross TJ, Stein EA

Abstract

Normal human behavior and cognition are reliant on a person's ability to inhibit inappropriate thoughts, impulses, and actions. The temporal and spatial advantages of event-related functional MRI (fMRI) were exploited to identify cortical regions that showed a transient change in fMRI signal after the withholding of a prepotent motor response. The temporal specificity of the event-related fMRI design also minimized possible contamination from response inhibition errors (i. e., commission errors) and other extraneous processes. Regions identified were strongly lateralized to the right hemisphere and included the middle and inferior frontal gyri, frontal limbic area, anterior insula, and inferior parietal lobe. Contrary to the prominence traditionally given to ventral frontal regions for response inhibition, the results suggest that response inhibition is accomplished by a distributed cortical network.

MeSH Terms
Adult Brain/physiology Brain Mapping/methods Dominance, Cerebral/physiology Female Humans Inhibition, Psychological Magnetic Resonance Imaging/methods Male Prefrontal Cortex/physiology Regression Analysis
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Garavan H
Department of Psychiatry, Medical College of Wisconsin, Milwaukee, WI 53226, USA. [email protected]
Ross T J
Stein E A
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.96.14.8301
Email
[email protected]
Published
1999-07-06
Pages
8301-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC22229
Subset
IM
Grants
NIDA NIH HHS · DA09465 · United States
NCRR NIH HHS · M01 RR000058 · United States
NIDA NIH HHS · DA10214 · United States
NCRR NIH HHS · RR-00058 · United States
NIDA NIH HHS · R01 DA009465 · United States
NIDA NIH HHS · R01 DA010214 · United States
External Links
PubMed source DOI: 10.1073/pnas.96.14.8301 PMC Full Text View journal details
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