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PMID: 10440223 Published · ppublish English Journal Article Review

Activation of the AP-1 transcription factor by inflammatory cytokines of the TNF family.

Gene expression ·Vol. 7 ·No. 4-6 ·1999-00-00 ·Pages 217-31

Kyriakis JM

Abstract

Inflammatory cytokines of the tumor necrosis factor (TNF) family mediate a large variety of cellular and organismal inflammatory responses and are important to the pathogenesis of a number of important disease states including arthritis, septic shock, inflammatory bowel disease, and, possibly, type II diabetes. Many of the responses to these cytokines require de novo gene expression mediated by the activator protein-1 (AP-1) heterodimeric transcription factor. This review will discuss what is known of how cytokines of the TNF family, acting at the cell surface, recruit two mitogen-activated protein kinase (MAPK) subfamilies, the stress-activated protein kinases (SAPKs, also called JNKs) and the p38s, to transduce signals to AP-1.

MeSH Terms
Amino Acid Sequence Animals Calcium-Calmodulin-Dependent Protein Kinases/metabolism Gene Expression Regulation Humans Mitogen-Activated Protein Kinases Molecular Sequence Data Proteins/metabolism Receptors, Tumor Necrosis Factor/metabolism Signal Transduction TNF Receptor-Associated Factor 1 Transcription Factor AP-1/metabolism Tumor Necrosis Factor-alpha/metabolism p38 Mitogen-Activated Protein Kinases
Chemicals
Proteins Receptors, Tumor Necrosis Factor TNF Receptor-Associated Factor 1 Transcription Factor AP-1 Tumor Necrosis Factor-alpha Calcium-Calmodulin-Dependent Protein Kinases Mitogen-Activated Protein Kinases p38 Mitogen-Activated Protein Kinases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kyriakis J M
Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Charlestown, USA. [email protected]
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Article Info
Journal
Gene expression
Abbr.
Gene Expr
ISSN
1052-2166
Email
[email protected]
Published
1999-00-00
Pages
217-31
Language
English
Region
United States
NLM ID
9200651
PMCID
PMC6174675
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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