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PMID: 10440228 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Heat shock factor function and regulation in response to cellular stress, growth, and differentiation signals.

Gene expression ·Vol. 7 ·No. 4-6 ·1999-00-00 ·Pages 271-82

Morano KA, Thiele DJ

Abstract

Heat shock factors (HSF) activate the transcription of genes encoding products required for protein folding, processing, targeting, degradation, and function. Although HSFs have been extensively studied with respect to their role in thermotolerance and the activation of gene expression in response to environmental stress, the involvement of HSFs in response to stresses associated with cell growth and differentiation, and in response to normal physiological processes is becoming increasingly clear. In this work, we review recent advances toward understanding how cells transmit growth control and developmental signals, and interdigitate cellular physiology, to regulate HSF function.

MeSH Terms
Animals Apoptosis Cell Differentiation/physiology Cell Division/physiology DNA-Binding Proteins/physiology Gametogenesis HSP90 Heat-Shock Proteins/metabolism Heat Shock Transcription Factors Heat-Shock Proteins/physiology Humans Transcription Factors/physiology
Chemicals
DNA-Binding Proteins HSP90 Heat-Shock Proteins Heat Shock Transcription Factors Heat-Shock Proteins Transcription Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Morano K A
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109-0606, USA.
Thiele D J
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Article Info
Journal
Gene expression
Abbr.
Gene Expr
ISSN
1052-2166
Published
1999-00-00
Pages
271-82
Language
English
Region
United States
NLM ID
9200651
PMCID
PMC6174667
Subset
IM
Grants
NIGMS NIH HHS · F32 GM019195 · United States
NCI NIH HHS · T32 CA009676 · United States
NIGMS NIH HHS · 1F32GM19195-01 · United States
NCI NIH HHS · 5T32CA09676-06 · United States
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