The three major Spanish clones of penicillin-resistant Streptococcus pneumoniae are the most common clones recovered in recent cases of meningitis in Spain.

Journal of clinical microbiology ·Vol. 37 ·No. 10 ·1999-10-00 ·Pages 3210-6

Enright MC, Fenoll A, Griffiths D, Spratt BG

Abstract

One hundred six isolates of Streptococcus pneumoniae recovered in Spain from patients with meningitis in 1997 and 1998 were characterized by multilocus sequence typing. A heterogeneous collection of genotypes was associated with meningitis in Spain: 65 different sequence types were resolved and, even at a genetic distance of 0.43, there were 37 distinct lineages. Thirty-eight percent of the isolates, including all isolates of serotypes 6B, 9V, 14, and 23F, were resistant to penicillin, and 24% of the isolates were members of the three major Spanish penicillin-resistant or multidrug-resistant clones of serotypes 6B, 9V, and 23F or serotype variants of these clones. These three clones (MICs, 1 to 2 microg of penicillin/ml) were the most common clones associated with pneumococcal meningitis in Spain during 1997 and 1998. Only two of the other clones associated with meningitis were penicillin resistant (MICs, 0.12 to 0.5 microg/ml). One of the two most prevalent penicillin-susceptible clones causing meningitis (serotype 3) has not been detected outside of Spain, whereas the other (serotype 18C) has been recovered from patients with meningitis in the United Kingdom, The Netherlands, and Denmark. The prevalence of meningitis caused by isolates of the three major Spanish penicillin-resistant or multiply antibiotic-resistant clones, which are now globally distributed, is disturbing and clearly establishes their ability to cause life-threatening disease.

MeSH Terms

Base Sequence Humans Meningitis, Pneumococcal/microbiology Microbial Sensitivity Tests Molecular Sequence Data Penicillin Resistance Spain Streptococcus pneumoniae/classification,drug effects,genetics

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Enright M C

Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford OX1 3FY, United Kingdom.

Fenoll A

Griffiths D

Spratt B G

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Article Info

Journal

Journal of clinical microbiology

Abbr.

J Clin Microbiol

ISSN

0095-1137

DOI

10.1128/JCM.37.10.3210-3216.1999

Published

1999-10-00

Pages

3210-6

Language

English

Region

United States

NLM ID

7505564

PMCID

PMC85530

Subset

Grants

Wellcome Trust · United Kingdom

Databases

GENBANK

AJ252518, AJ252519, AJ252520, AJ252521, AJ252522, AJ252523, AJ252524, AJ252525, AJ252526, AJ252527, AJ252528, AJ252529, AJ252530, AJ252531, AJ252532, AJ252533, AJ252534, AJ252535, AJ252536, AJ252537, AJ252538, AJ252539, AJ252540, AJ252541, AJ252542, AJ252543, AJ252544, AJ252545, AJ252546, AJ252547

External Links

PubMed source DOI: 10.1128/JCM.37.10.3210-3216.1999 PMC Full Text View journal details

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The three major Spanish clones of penicillin-resistant Streptococcus pneumoniae are the most common clones recovered in recent cases of meningitis in Spain.

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