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PMID: 10490658 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality.

Molecular and cellular biology ·Vol. 19 ·No. 10 ·1999-10-00 ·Pages 7237-44

Donohoe ME, Zhang X, McGinnis L, Biggers J, Li E, Shi Y

Abstract

Yin Yang 1 (YY1) is a zinc finger-containing transcription factor and a target of viral oncoproteins. To determine the biological role of YY1 in mammalian development, we generated mice deficient for YY1 by gene targeting. Homozygosity for the mutated YY1 allele results in embryonic lethality in the mouse. YY1 mutants undergo implantation and induce uterine decidualization but rapidly degenerate around the time of implantation. A subset of YY1 heterozygote embryos are developmentally retarded and exhibit neurulation defects, suggesting that YY1 may have additional roles during later stages of mouse embryogenesis. Our studies demonstrate an essential function for YY1 in the development of the mouse embryo.

MeSH Terms
Animals DNA-Binding Proteins/genetics Embryo Implantation/genetics Erythroid-Specific DNA-Binding Factors Female Genes, Lethal Heterozygote Homozygote Mice Mice, Mutant Strains/embryology Neural Tube Defects Transcription Factors/genetics YY1 Transcription Factor
Chemicals
DNA-Binding Proteins Erythroid-Specific DNA-Binding Factors Transcription Factors YY1 Transcription Factor Yy1 protein, mouse
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Donohoe M E
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Zhang X
McGinnis L
Biggers J
Li E
Shi Y
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/MCB.19.10.7237
Published
1999-10-00
Pages
7237-44
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC84716
Subset
IM
Grants
NIGMS NIH HHS · R01 GM053874 · United States
NCI NIH HHS · T32 CA009031 · United States
NIGMS NIH HHS · GM 53874 · United States
NCI NIH HHS · T32CA09031-22 · United States
External Links
PubMed source DOI: 10.1128/MCB.19.10.7237 PMC Full Text View journal details
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