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PMID: 10503240 Published · ppublish English Journal Article Review

Polyamines. An overview.

Molecular biotechnology ·Vol. 11 ·No. 3 ·1999-06-00 ·Pages 229-50

Morgan DM

Abstract

The polyamines spermine, spermidine, and putrescine are small organic molecules one or more of which are present in all living organisms. Many natural products contain polyamine residues. Polyamines are synthesized by a highly regulated pathway from arginine or ornithine and also can be transported in and out of cells. Polyamines are degraded to a variety of compounds the functions of which are largely unknown. Polyamines influence the transcriptional and translational stages of protein synthesis, stabilize membranes, and, in mammalian systems, modulate neurophysiological functions and may act as intracellular messengers. However, at the molecular level the mode of action of the polyamines is largely unknown.

MeSH Terms
Animals Biogenic Polyamines/metabolism Homeostasis Humans
Chemicals
Biogenic Polyamines
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Morgan D M
[email protected]
References (132)
132 references, click to expand
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Article Info
Journal
Molecular biotechnology
Abbr.
Mol Biotechnol
ISSN
1073-6085
DOI
10.1007/BF02788682
Email
[email protected]
Published
1999-06-00
Pages
229-50
Language
English
Region
United States
NLM ID
9423533
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02788682 View journal details
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