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PMID: 10527927 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function.

The Biochemical journal ·Vol. 343 Pt 3 ·1999-11-01 ·Pages 505-15

Zammit VA

Abstract

Long-chain acyl-CoA esters have potent specific actions (e.g. on gene transcription, membrane trafficking) as well as non-specific ones (e.g. on phospholipid bilayers). They are synthesized on the cytosolic aspects of several intracellular membranes, to give rise to (a) cytosolic pool(s) to which a variety of enzymes and processes have access, including some localized in the nucleus. Their concentration in cells is highly regulated, interconversion with corresponding acylcarnitines being the most important mechanism involved. This reaction is catalysed by cytosol-accessible carnitine long-chain acyl (palmitoyl) transferase activities that are themselves located on multiple membrane systems. Regulation of these activities is through the inhibitory action of malonyl-CoA. Hence the existence of a potent malonyl-CoA-acyl-CoA axis through which many processes involved in the maintenance of mammalian cell function are regulated. The molecular, topographical and physiological interactions that make this possible are described and discussed.

MeSH Terms
Acyl Coenzyme A/metabolism Animals Carnitine O-Palmitoyltransferase/metabolism Cell Physiological Phenomena Cytosol/enzymology Malonyl Coenzyme A/metabolism Mammals
Chemicals
Acyl Coenzyme A Malonyl Coenzyme A Carnitine O-Palmitoyltransferase
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Zammit V A
Cell Biochemistry, Hannah Research Institute, Ayr, KA6 5HL, Scotland, U.K. [email protected]
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
Email
[email protected]
Published
1999-11-01
Pages
505-15
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1220580
Subset
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