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PMID: 10550321 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Insulin-like growth factor I reverses experimental diabetic autonomic neuropathy.

The American journal of pathology ·Vol. 155 ·No. 5 ·1999-11-00 ·Pages 1651-60

Schmidt RE, Dorsey DA, Beaudet LN, Plurad SB, Parvin CA, Miller MS

Abstract

Recent studies have suggested a role for neurotrophic substances in the pathogenesis and treatment of diabetic neuropathy. In this study, the effect of insulin-like growth factor I (IGF-I) on diabetic sympathetic autonomic neuropathy was examined in an experimental streptozotocin-induced diabetic rat model. Two months of IGF-I treatment of chronically diabetic rats with established neuroaxonal dystrophy (the neuropathological hallmark of the disease) involving the superior mesenteric ganglion and ileal mesenteric nerves resulted in nearly complete normalization of the frequency of neuroaxonal dystrophy in both sites without altering the severity of diabetes. Treatment with low-dose insulin (to control for the transient glucose-lowering effects of IGF-I) failed to affect the frequency of ganglionic or mesenteric nerve neuroaxonal dystrophy or the severity of diabetes. The striking improvement in the severity of diabetic autonomic neuropathy shown with IGF-I treatment in these studies and the fidelity of the rat model to findings in diabetic human sympathetic ganglia provide promise for the development of new clinical therapeutic strategies.

MeSH Terms
Animals Diabetes Mellitus, Experimental/drug therapy,pathology,physiopathology Diabetic Neuropathies/drug therapy,pathology,physiopathology Humans Insulin-Like Growth Factor I/pharmacology,therapeutic use Male Microscopy, Electron Rats Rats, Sprague-Dawley Streptozocin Sympathetic Nervous System/drug effects,physiopathology,ultrastructure
Chemicals
Streptozocin Insulin-Like Growth Factor I
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Schmidt R E
Division of Neuropathology, Department of Pathology, Washington University School of Medicine, St. Louis, Missouri, USA. [email protected]
Dorsey D A
Beaudet L N
Plurad S B
Parvin C A
Miller M S
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
DOI
10.1016/S0002-9440(10)65480-6
Email
[email protected]
Published
1999-11-00
Pages
1651-60
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1866997
Subset
IM
Grants
NIDDK NIH HHS · R01 DK019645 · United States
NIA NIH HHS · AG10299 · United States
NIDDK NIH HHS · DK19645 · United States
NIDDK NIH HHS · R37 DK019645 · United States
NIA NIH HHS · R01 AG010299 · United States
External Links
PubMed source DOI: 10.1016/S0002-9440(10)65480-6 PMC Full Text View journal details
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