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PMID: 1064853 Published · ppublish English Journal Article

Localization of acetylcholine receptors during synaptogenesis in retina.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 6 ·1976-06-00 ·Pages 1806-10

Vogel Z, Nirenberg M

Abstract

Nicotinic acetylcholine receptors are synthesized in chick embryo retina before synapses appear. Most of the receptors are found associated with neurites in the inner synaptic layer of the retina; later in development the receptors appear in the outer synaptic layer. Cells dissociated from retina and cultured in vitro form aggregates and also sort out into regions comprised either of neurites or cell bodies. Most of the nicotinic acetylcholine receptors of aggregates are found associated with neurite regions. The receptor distribution of cultured retina cells thus resembles that of intact retina.

MeSH Terms
Age Factors Animals Autoradiography Binding Sites Bungarotoxins/metabolism Cells, Cultured Chick Embryo Receptors, Cholinergic Retina/embryology,metabolism,ultrastructure Synapses
Chemicals
Bungarotoxins Receptors, Cholinergic
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Vogel Z
Nirenberg M
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26 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.6.1806
Published
1976-06-00
Pages
1806-10
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC430395
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.6.1806 PMC Full Text View journal details
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