In vitro activity of rosamicin, josamycin, erythromycin, and clindamycin against beta-lactamase-nagative and beta-lactamase-positive strains of Neisseria gonorrhoeae.

Antimicrobial agents and chemotherapy ·Vol. 15 ·No. 2 ·1979-02-00 ·Pages 243-5

Biddle JW, Thornsberry C

Abstract

Randomly selected strains of beta-lactamase-negative and beta-lactamase-positive Neisseria gonorrhoeae were tested by an agar dilution method for susceptibility to rosamicin, josamycin, erythromycin, clindamycin, and penicillin G. Rosamicin was more active than erythromycin, which was more active than josamycin or clindamycin; the latter two were similar in their activity. The susceptibility to the macrolide antibiotics and clindamycin was independent of beta-lactamase production, but the penicillin minimal inhibitory concentrations were higher in the beta-lactamase-positive group because of the enzyme.

MeSH Terms

Anti-Bacterial Agents/pharmacology Clindamycin/pharmacology Erythromycin/pharmacology Leucomycins/pharmacology Microbial Sensitivity Tests Neisseria gonorrhoeae/drug effects,enzymology beta-Lactamases/metabolism

Chemicals

Anti-Bacterial Agents Leucomycins Clindamycin Erythromycin beta-Lactamases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Biddle J W

Thornsberry C

References (15)

15 references, click to expand

National gonorrhea therapy monitoring study: treatment results.
N Engl J Med. 1976 Jan 1;294(1):1-4 PMID: 127945
Spectinomycin-resistant Neisseria gonorrhoeae.
JAMA. 1977 May 30;237(22):2405-6 PMID: 140251
NEISSERIA GONORRHOEAE IDENTIFICATION IN DIRECT SMEARS BY A FLUORESCENT ANTIBODY-COUNTERSTAIN METHOD.
Appl Microbiol. 1965 Mar;13:171-4 PMID: 14325874
Rosamicin--a new drug for the treatment of bacterial prostatitis.
Antimicrob Agents Chemother. 1977 Aug;12(2):240-2 PMID: 332074
In vitro susceptibility studies with josamycin and erythromycin.
Antimicrob Agents Chemother. 1976 Mar;9(3):546-8 PMID: 4012
Comparison of erythromycin base and estolate in gonococcal urethritis.
JAMA. 1977 Sep 26;238(13):1371-3 PMID: 408522
In vitro activity of rosamicin against Neisseria and Haemophilus, including penicillinase-producing strains.
Antimicrob Agents Chemother. 1977 Aug;12(2):293-4 PMID: 409345
Antibiotic resistance in Neisseria gonorrhoeae.
Med Clin North Am. 1972 Sep;56(5):1133-44 PMID: 4262305
Spectinomycin hydrochloride (Trobicin) in the treatment of gonorrhoea. Observation of resistant strains of Neisseria gonorrhoeae.
Br J Vener Dis. 1973 Feb;49(1):54-9 PMID: 4266505
Comparative study of gonococcal susceptibility to penicillin in the United States, 1955-1969.
J Infect Dis. 1970 Nov;122(5):459-61 PMID: 4990947
Beta-lactamase-producing, penicillin-resistant gonococcus.
Lancet. 1976 Sep 25;2(7987):656-7 PMID: 60518
Penicillinase-producing Neisseria gonorrhoeae.
Lancet. 1976 Sep 25;2(7987):657-8 PMID: 60519
In vitro activity of josamycin against aerobic gram-positive cocci and anaerobes.
Antimicrob Agents Chemother. 1976 Jun;9(6):988-93 PMID: 7189
Rosamicin in urethral and vaginal secretions and tissues in dogs and rats.
Antimicrob Agents Chemother. 1977 Aug;12(2):237-9 PMID: 900921
Comparative pharmacology of josamycin and erythromycin stearate.
Antimicrob Agents Chemother. 1976 Sep;10(3):450-6 PMID: 984786

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.15.2.243

Published

1979-02-00

Pages

243-5

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC352640

Subset

External Links

PubMed source DOI: 10.1128/AAC.15.2.243 PMC Full Text View journal details

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In vitro activity of rosamicin, josamycin, erythromycin, and clindamycin against beta-lactamase-nagative and beta-lactamase-positive strains of Neisseria gonorrhoeae.

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