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PMID: 10688427 Published · ppublish English Journal Article Review

Biologic functions of the IFN-gamma receptors.

Allergy ·Vol. 54 ·No. 12 ·1999-12-00 ·Pages 1233-51

Tau G, Rothman P

Abstract

Interferon-gamma (IFN-gamma) is a cytokine that plays an important role in inducing and modulating an array of immune responses. Cellular responses to IFN-gamma are mediated by its heterodimeric cell-surface receptor (IFN-gammaR), which activates downstream signal transduction cascades, ultimately leading to the regulation of gene expression. In order to study the role of IFN-gamma in a number of immune responses and pathways, researchers have generated mice with altered patterns of IFN-gammaR gene expression. These studies, together with analyses of naturally occurring mutations of the IFN-gammaR in man, have been instrumental in elucidating the diverse functions of IFN-gamma, and are the subject of this review.

MeSH Terms
Animals Gene Expression Humans Immunity, Cellular Mice Receptors, Interferon/genetics,physiology Signal Transduction
Chemicals
Receptors, Interferon interferon gamma receptor
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Tau G
Integrated Program in Cellular, Molecular Biology and Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Rothman P
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Article Info
Journal
Allergy
Abbr.
Allergy
ISSN
0105-4538
DOI
10.1034/j.1398-9995.1999.00099.x
Published
1999-12-00
Pages
1233-51
Language
English
Region
Denmark
NLM ID
7804028
PMCID
PMC4154595
Subset
IM
Grants
NIGMS NIH HHS · T32 GM007367 · United States
External Links
PubMed source DOI: 10.1034/j.1398-9995.1999.00099.x PMC Full Text View journal details
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