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PMID: 10690404 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Review

Mechanisms of stationary phase mutation: a decade of adaptive mutation.

Annual review of genetics ·Vol. 33 ·1999-00-00 ·Pages 57-88

Foster PL

Abstract

A decade of research on adaptive mutation has revealed a plethora of mutagenic mechanisms that may be important in evolution. The DNA synthesis associated with recombination could be an important source of spontaneous mutation in cells that are not proliferating. The movement of insertion elements can be responsive to environmental conditions. Insertion elements not only activate and inactivate genes, they also provide sequence homology that allows large-scale genomic rearrangements. Some conjugative plasmids can recombine with their host's chromosome, and may acquire chromosomal genes that could then spread through the population and even to other species. Finally, a subpopulation of transient hypermutators could be a source of multiple variant alleles, providing a mechanism for rapid evolution under adverse conditions.

MeSH Terms
Adaptation, Physiological/genetics Animals Bacteria/genetics Biological Evolution DNA Replication Escherichia coli/genetics Mutation
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Foster P L
Department of Biology, Indiana University, Bloomington 47405, USA. [email protected]
References (151)
151 references, click to expand
  1. Direct selection for mutators in Escherichia coli.
    J Bacteriol. 1999 Mar;181(5):1576-84 PMID: 10049391
  2. Are adaptive mutations due to a decline in mismatch repair? The evidence is lacking.
    Mutat Res. 1999 Mar;436(2):179-84 PMID: 10095139
  3. Genomic evolution during a 10,000-generation experiment with bacteria.
    Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3807-12 PMID: 10097119
  4. Phenotypic change caused by transcriptional bypass of uracil in nondividing cells.
    Science. 1999 Apr 2;284(5411):159-62 PMID: 10102819
  5. Hypermutation in derepressed operons of Escherichia coli K12.
    Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5089-94 PMID: 10220423
  6. Increased episomal replication accounts for the high rate of adaptive mutation in recD mutants of Escherichia coli.
    Genetics. 1999 May;152(1):15-30 PMID: 10224241
  7. Starvation-induced Mucts62-mediated coding sequence fusion: a role for ClpXP, Lon, RpoS and Crp.
    Mol Microbiol. 1999 Apr;32(2):327-43 PMID: 10231489
  8. The role of transient hypermutators in adaptive mutation in Escherichia coli.
    Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6862-7 PMID: 10359804
  9. Mechanisms of mutation in nondividing cells. Insights from the study of adaptive mutation in Escherichia coli.
    Ann N Y Acad Sci. 1999 May 18;870:133-45 PMID: 10415479
  10. Is there a link between mutation rates and the stringent response in Bacillus subtilis?
    Ann N Y Acad Sci. 1999 May 18;870:418-22 PMID: 10415512
  11. Environmentally directed mutations in the dehalogenase system of Pseudomonas putida strain PP3.
    Arch Microbiol. 1992;158(3):176-82 PMID: 1332636
  12. Is DNA replication a necessary condition for spontaneous mutation?
    Z Vererbungsl. 1961;92:38-41 PMID: 13744985
  13. Spontaneous mutation in spheroplasts of Escherichia coli.
    J Gen Microbiol. 1963 Feb;30:193-9 PMID: 13975747
  14. SELFER MUTANTS OF SALMONELLA TYPHIMURIUM.
    Genetics. 1963 Nov;48:1519-31 PMID: 14083047
  15. Sequence analysis of mutations arising during prolonged starvation of Salmonella typhimurium.
    Genetics. 1992 Oct;132(2):303-10 PMID: 1427030
  16. Bacterial mutation in a stationary phase and the question of cell turnover.
    J Gen Microbiol. 1959 Dec;21:530-49 PMID: 14440412
  17. The role of oriT in tra-dependent enhanced recombination between mini-F-lac-oriT and lambda plac5.
    Genet Res. 1992 Jun;59(3):157-65 PMID: 1511865
  18. Mechanisms of directed mutation.
    Genetics. 1992 Aug;131(4):783-9 PMID: 1516815
  19. Translational errors as the cause of mutations in Escherichia coli.
    Mol Gen Genet. 1992 Feb;231(3):469-71 PMID: 1538699
  20. Directed mutation: between unicorns and goats.
    J Bacteriol. 1992 Mar;174(6):1711-6 PMID: 1548222
  21. Experimental evidence for an alternative to directed mutation in the bgl operon.
    Nature. 1992 Apr 2;356(6368):446-8 PMID: 1557128
  22. Transient mutators: a semiquantitative analysis of the influence of translation and transcription errors on mutation rates.
    Genetics. 1991 Nov;129(3):957-62 PMID: 1752431
  23. Spectrum of mutations that occur under selective and non-selective conditions in E. coli.
    Genetica. 1991;84(2):73-6 PMID: 1756965
  24. Adaptive reversion of a frameshift mutation in Escherichia coli.
    Genetics. 1991 Aug;128(4):695-701 PMID: 1916241
  25. Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase.
    J Bacteriol. 1991 Mar;173(6):2068-76 PMID: 2002008
  26. Adaptive evolution that requires multiple spontaneous mutations: mutations involving base substitutions.
    Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5882-6 PMID: 2062865
  27. Directed evolution of a bacterial operon.
    Bioessays. 1990 Nov;12(11):551-8 PMID: 2085322
  28. Histone-like protein H1 (H-NS), DNA supercoiling, and gene expression in bacteria.
    Cell. 1990 Nov 2;63(3):631-42 PMID: 2171779
  29. Action of a transposable element in coding sequence fusions.
    Genetics. 1990 Oct;126(2):293-9 PMID: 2174011
  30. A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy.
    Biochemistry. 1990 Mar 13;29(10):2532-7 PMID: 2185829
  31. Mechanism for induction of adaptive mutations in Escherichia coli.
    Mol Microbiol. 1990 Apr;4(4):597-601 PMID: 2191182
  32. A set of lacZ mutations in Escherichia coli that allow rapid detection of specific frameshift mutations.
    Genetics. 1990 Jun;125(2):275-80 PMID: 2199309
  33. Spontaneous point mutations that occur more often when advantageous than when neutral.
    Genetics. 1990 Sep;126(1):5-16 PMID: 2227388
  34. New data on excisions of Mu from E. coli MCS2 cast doubt on directed mutation hypothesis.
    Nature. 1990 Mar 8;344(6262):173-5 PMID: 2407962
  35. A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions.
    Proc Natl Acad Sci U S A. 1989 Jul;86(14):5345-9 PMID: 2501784
  36. DNA sequence analysis of artificially evolved ebg enzyme and ebg repressor genes.
    Genetics. 1989 Dec;123(4):635-48 PMID: 2515108
  37. Evolution. Anticipatory mutagenesis.
    Nature. 1989 Jan 12;337(6203):119-20 PMID: 2643053
  38. Spontaneous and UV-induced mutations in Escherichia coli K-12 strains with altered or absent DNA polymerase I.
    J Bacteriol. 1989 May;171(5):2480-4 PMID: 2651403
  39. Transcriptional bias: a non-Lamarckian mechanism for substrate-induced mutations.
    Proc Natl Acad Sci U S A. 1989 Jul;86(13):5005-9 PMID: 2740338
  40. Dehalogenase genes of Pseudomonas putida PP3 on chromosomally located transposable elements.
    Mol Biol Evol. 1985 Nov;2(6):557-67 PMID: 2835577
  41. Adaptive evolution that requires multiple spontaneous mutations. I. Mutations involving an insertion sequence.
    Genetics. 1988 Dec;120(4):887-97 PMID: 2852143
  42. THE CHALLENGES TO DARWINISM SINCE THE LAST CENTENNIAL AND THE IMPACT OF MOLECULAR STUDIES.
    Evolution. 1982 Nov;36(6):1133-1143 PMID: 28563562
  43. Effects of amino acid substitutions at the active site in Escherichia coli beta-galactosidase.
    Genetics. 1988 Nov;120(3):637-44 PMID: 2906303
  44. Conjugation-dependent enhancement of induced and spontaneous mutation in the lacI gene of E. coli.
    Mol Gen Genet. 1985;201(1):35-7 PMID: 2997581
  45. The origin of mutants.
    Nature. 1988 Sep 8;335(6186):142-5 PMID: 3045565
  46. Bacterial genetics. A unicorn in the garden.
    Nature. 1988 Sep 8;335(6186):112-3 PMID: 3412467
  47. DNA turnover in buffer-held Escherichia coli and its effect on repair of UV damage.
    Photochem Photobiol. 1979 Mar;29(3):511-20 PMID: 375250
  48. Mutagenic specificity of ultraviolet light.
    J Mol Biol. 1985 Mar 5;182(1):45-65 PMID: 3923204
  49. Lac repressor can be fused to beta-galactosidase.
    Nature. 1974 Jun 7;249(457):561-3 PMID: 4599764
  50. Selection for high mutation rates in chemostats.
    Genetics. 1974 Jun;77(2):169-84 PMID: 4603159
  51. The evolution of mutation rates.
    Genetics. 1973 Apr;73:Suppl 73:1-18 PMID: 4711556
  52. Amino acid replacements and the genetic code.
    Cold Spring Harb Symp Quant Biol. 1966;31:151-62 PMID: 4866372
  53. Analysis of amino acid replacements resulting from frameshift and missense mutations in the tryptophan synthetase A gene of Escherichia coli.
    J Mol Biol. 1968 Jul 14;34(2):219-38 PMID: 4938546
  54. The reversible suppression of stationary phase mutation in Escherichia coli by caffeine.
    Genetics. 1966 May;53(5):823-34 PMID: 5333373
  55. Observations on the formation of clones containing araB-lacZ cistron fusions.
    Mol Gen Genet. 1984;194(1-2):79-90 PMID: 6233472
  56. Insertion of DNA activates the cryptic bgl operon in E. coli K12.
    Nature. 1981 Oct 22;293(5834):625-9 PMID: 6270569
  57. Gene amplification in the lac region of E. coli.
    Cell. 1984 May;37(1):217-24 PMID: 6327052
  58. The infidelity of conjugal DNA transfer in Escherichia coli.
    Genetics. 1983 Nov;105(3):489-500 PMID: 6357941
  59. Genetic and sequence analysis of frameshift mutations induced by ICR-191.
    J Mol Biol. 1981 Nov 25;153(1):39-64 PMID: 7040679
  60. Starvation-associated mutation in Escherichia coli: a spontaneous lesion hypothesis for "directed" mutation.
    Mutat Res. 1994 May 1;307(1):149-56 PMID: 7513791
  61. Starvation-associated mutation in E. coli strains with and without reverse transcriptase.
    Mutat Res. 1995 Jun;347(1):13-5 PMID: 7541110
  62. Collapse and repair of replication forks in Escherichia coli.
    Mol Microbiol. 1995 May;16(3):373-84 PMID: 7565099
  63. Conjugation is not required for adaptive reversion of an episomal frameshift mutation in Escherichia coli.
    J Bacteriol. 1995 Nov;177(22):6670-1 PMID: 7592449
  64. mutY 'directs' mutation?
    Nature. 1995 Jun 29;375(6534):741 PMID: 7596405
  65. Catabolite-mediated mutations in alternate toluene degradative pathways in Pseudomonas putida.
    J Bacteriol. 1995 Aug;177(16):4713-20 PMID: 7642499
  66. Proofreading-defective DNA polymerase II increases adaptive mutation in Escherichia coli.
    Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7951-5 PMID: 7644519
  67. DNA synthesis errors associated with double-strand-break repair.
    Genetics. 1995 Jul;140(3):965-72 PMID: 7672595
  68. Spontaneous mutation in stationary-phase Escherichia coli WP2 carrying various DNA repair alleles.
    Mutat Res. 1993 Jul;302(3):173-6 PMID: 7686628
  69. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.
    Mutat Res. 1975 Dec;31(6):347-64 PMID: 768755
  70. Genetics of selection-induced mutations: I. uvrA, uvrB, uvrC, and uvrD are selection-induced specific mutator loci.
    J Mol Evol. 1995 Jan;40(1):86-93 PMID: 7714915
  71. Adaptive mutation in Escherichia coli: a role for conjugation.
    Science. 1995 Apr 21;268(5209):418-20 PMID: 7716545
  72. Evidence that F plasmid transfer replication underlies apparent adaptive mutation.
    Science. 1995 Apr 21;268(5209):421-3 PMID: 7716546
  73. Starvation-associated mutation in Escherichia coli strains defective in transcription repair coupling factor.
    Mutat Res. 1995 Jun;329(1):49-56 PMID: 7770075
  74. Adaptive reversion of an episomal frameshift mutation in Escherichia coli requires conjugal functions but not actual conjugation.
    Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5487-90 PMID: 7777535
  75. Association of increased spontaneous mutation rates with high levels of transcription in yeast.
    Science. 1995 Jun 16;268(5217):1616-9 PMID: 7777859
  76. Transcription-coupled repair and human disease.
    Science. 1994 Dec 23;266(5193):1957-8 PMID: 7801121
  77. Population dynamics of a Lac- strain of Escherichia coli during selection for lactose utilization.
    Genetics. 1994 Oct;138(2):253-61 PMID: 7828809
  78. A test of the directed mutation hypothesis in Escherichia coli MCS2 using replica plating.
    J Bacteriol. 1995 Feb;177(4):1119-20 PMID: 7860594
  79. Insertion sequence-related genetic variation in resting Escherichia coli K-12.
    Genetics. 1994 Mar;136(3):721-30 PMID: 7911771
  80. Involvement of Escherichia coli DNA polymerase II in response to oxidative damage and adaptive mutation.
    J Bacteriol. 1994 Oct;176(20):6221-8 PMID: 7928992
  81. The roles of starvation and selective substrates in the emergence of araB-lacZ fusion clones.
    EMBO J. 1994 Nov 1;13(21):5229-39 PMID: 7957088
  82. The occurrence of heritable Mu excisions in starving cells of Escherichia coli.
    EMBO J. 1994 Nov 1;13(21):5240-4 PMID: 7957089
  83. Biochemistry of homologous recombination in Escherichia coli.
    Microbiol Rev. 1994 Sep;58(3):401-65 PMID: 7968921
  84. Adaptive mutation by deletions in small mononucleotide repeats.
    Science. 1994 Jul 15;265(5170):405-7 PMID: 8023163
  85. Adaptive reversion of a frameshift mutation in Escherichia coli by simple base deletions in homopolymeric runs.
    Science. 1994 Jul 15;265(5170):407-9 PMID: 8023164
  86. Recombination in adaptive mutation.
    Science. 1994 Apr 8;264(5156):258-60 PMID: 8146657
  87. On alternatives to selection-induced mutation in the Bgl operon of Escherichia coli.
    Mol Biol Evol. 1994 Mar;11(2):159-68 PMID: 8170359
  88. DNA alkylation repair limits spontaneous base substitution mutations in Escherichia coli.
    J Bacteriol. 1994 Jun;176(11):3224-30 PMID: 8195077
  89. Adaptive mutation: the uses of adversity.
    Annu Rev Microbiol. 1993;47:467-504 PMID: 8257106
  90. Antimutator mutations in the alpha subunit of Escherichia coli DNA polymerase III: identification of the responsible mutations and alignment with other DNA polymerases.
    Genetics. 1993 Aug;134(4):1039-44 PMID: 8375647
  91. A role for the Clp protease in activating Mu-mediated DNA rearrangements.
    J Bacteriol. 1993 May;175(9):2625-31 PMID: 8386721
  92. The role of single-mutant intermediates in the generation of trpAB double revertants during prolonged selection.
    J Bacteriol. 1993 Oct;175(20):6411-4 PMID: 8407817
  93. Adaptive mutation sequences reproduced by mismatch repair deficiency.
    Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12017-20 PMID: 8618835
  94. Elevated mutation rate in mutT bacteria during starvation: evidence for DNA turnover?
    J Bacteriol. 1996 May;178(9):2709-11 PMID: 8626342
  95. The RuvABC proteins and Holliday junction processing in Escherichia coli.
    J Bacteriol. 1996 Mar;178(5):1237-41 PMID: 8631697
  96. Depletion of the cellular amounts of the MutS and MutH methyl-directed mismatch repair proteins in stationary-phase Escherichia coli K-12 cells.
    J Bacteriol. 1996 Apr;178(8):2388-96 PMID: 8636043
  97. Effect of mutY and mutM/fpg-1 mutations on starvation-associated mutation in Escherichia coli: implications for the role of 7,8-dihydro-8-oxoguanine.
    Mol Gen Genet. 1996 Jun 12;251(3):352-7 PMID: 8676878
  98. A search for a general phenomenon of adaptive mutability.
    Genetics. 1996 Jun;143(2):645-59 PMID: 8725216
  99. Generation of an endogenous DNA-methylating agent by nitrosation in Escherichia coli.
    J Bacteriol. 1996 Sep;178(17):5105-11 PMID: 8752326
  100. Overexpression of vsr in Escherichia coli is mutagenic.
    J Bacteriol. 1996 Jul;178(14):4294-6 PMID: 8763960
  101. Two enzymes, both of which process recombination intermediates, have opposite effects on adaptive mutation in Escherichia coli.
    Genetics. 1996 Jan;142(1):25-37 PMID: 8770582
  102. Mosaic structure of plasmids from natural populations of Escherichia coli.
    Genetics. 1996 Jul;143(3):1091-100 PMID: 8807284
  103. Mismatch repair in replication fidelity, genetic recombination, and cancer biology.
    Annu Rev Biochem. 1996;65:101-33 PMID: 8811176
  104. Opposing roles of the holliday junction processing systems of Escherichia coli in recombination-dependent adaptive mutation.
    Genetics. 1996 Mar;142(3):681-91 PMID: 8849879
  105. The selection-induced His+ reversion in Salmonella typhimurium.
    Mutat Res. 1996 Oct 25;357(1-2):43-56 PMID: 8876679
  106. The rate of adaptive mutagenesis in Escherichia coli is enhanced by oxygen (superoxide).
    Mutat Res. 1996 Oct 25;357(1-2):231-6 PMID: 8876699
  107. Transcription-induced mutations: increase in C to T mutations in the nontranscribed strand during transcription in Escherichia coli.
    Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13919-24 PMID: 8943036
  108. Adaptive mutation and slow-growing revertants of an Escherichia coli lacZ amber mutant.
    Genetics. 1996 Dec;144(4):1337-41 PMID: 8978023
  109. Proliferation of mutators in A cell population.
    J Bacteriol. 1997 Jan;179(2):417-22 PMID: 8990293
  110. Does selective gene activation direct evolution?
    FEBS Lett. 1997 Jan 27;402(1):4-8 PMID: 9013846
  111. On the specificity of adaptive mutations.
    Genetics. 1997 Jan;145(1):39-44 PMID: 9017388
  112. Escherichia coli DNA polymerase II catalyzes chromosomal and episomal DNA synthesis in vivo.
    Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):946-51 PMID: 9023362
  113. Nonadaptive mutations occur on the F' episome during adaptive mutation conditions in Escherichia coli.
    J Bacteriol. 1997 Mar;179(5):1550-4 PMID: 9045812
  114. Recent horizontal transmission of plasmids between natural populations of Escherichia coli and Salmonella enterica.
    J Bacteriol. 1997 Mar;179(5):1622-7 PMID: 9045822
  115. Promoter-creating mutations in Pseudomonas putida: a model system for the study of mutation in starving bacteria.
    Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3134-9 PMID: 9096358
  116. Different structures of selected and unselected araB-lacZ fusions.
    Mol Microbiol. 1997 Mar;23(6):1133-45 PMID: 9106205
  117. A direct role for DNA polymerase III in adaptive reversion of a frameshift mutation in Escherichia coli.
    Mutat Res. 1997 Apr 14;375(1):19-24 PMID: 9129676
  118. DNA turnover and mutation in resting cells.
    Bioessays. 1997 Apr;19(4):347-52 PMID: 9136632
  119. Role of mutator alleles in adaptive evolution.
    Nature. 1997 Jun 12;387(6634):700-2 PMID: 9192893
  120. Evolution of high mutation rates in experimental populations of E. coli.
    Nature. 1997 Jun 12;387(6634):703-5 PMID: 9192894
  121. Genome-wide hypermutation in a subpopulation of stationary-phase cells underlies recombination-dependent adaptive mutation.
    EMBO J. 1997 Jun 2;16(11):3303-11 PMID: 9214645
  122. Mutation in Escherichia coli under starvation conditions: a new pathway leading to small deletions in strains defective in mismatch correction.
    EMBO J. 1997 Jun 2;16(11):3349-56 PMID: 9214650
  123. H-NS and RpoS regulate emergence of Lac Ara+ mutants of Escherichia coli MCS2.
    J Bacteriol. 1997 Jul;179(14):4620-2 PMID: 9226274
  124. Nitrosated peptides and polyamines as endogenous mutagens in O6-alkylguanine-DNA alkyltransferase deficient cells.
    Carcinogenesis. 1997 Aug;18(8):1561-7 PMID: 9276631
  125. Mismatch repair protein MutL becomes limiting during stationary-phase mutation.
    Genes Dev. 1997 Sep 15;11(18):2426-37 PMID: 9308969
  126. Counteraction by MutT protein of transcriptional errors caused by oxidative damage.
    Science. 1997 Oct 3;278(5335):128-30 PMID: 9311918
  127. The Vsr endonuclease of Escherichia coli: an efficient DNA repair enzyme and a potent mutagen.
    J Bacteriol. 1997 Oct;179(19):6048-52 PMID: 9324251
  128. Genetic variability and adaptation to stress.
    EXS. 1997;83:271-90 PMID: 9342853
  129. A genetic strategy to demonstrate the occurrence of spontaneous mutations in nondividing cells within colonies of Escherichia coli.
    Genetics. 1997 Nov;147(3):991-1001 PMID: 9383047
  130. Terminal inverted repeats of insertion sequence IS30 serve as targets for transposition.
    J Bacteriol. 1997 Dec;179(23):7551-8 PMID: 9393723
  131. Role of the core DNA polymerase III subunits at the replication fork. Alpha is the only subunit required for processive replication.
    J Biol Chem. 1998 Jan 23;273(4):2452-7 PMID: 9442096
  132. Gene amplification and genomic plasticity in prokaryotes.
    Annu Rev Genet. 1997;31:91-111 PMID: 9442891
  133. Activation of the bgl operon by adaptive mutation.
    Mol Biol Evol. 1998 Jan;15(1):1-5 PMID: 9491599
  134. The ins and outs of virulence gene expression: Mg2+ as a regulatory signal.
    Bioessays. 1998 Jan;20(1):96-101 PMID: 9504051
  135. Levels of the Vsr endonuclease do not regulate stationary-phase reversion of a Lac- frameshift allele in Escherichia coli.
    J Bacteriol. 1998 Apr;180(7):1944-6 PMID: 9537396
  136. Mutation and cancer: the antecedents to our studies of adaptive mutation.
    Genetics. 1998 Apr;148(4):1433-40 PMID: 9560363
  137. Adaptive mutation: has the unicorn landed?
    Genetics. 1998 Apr;148(4):1453-9 PMID: 9560365
  138. Transient and heritable mutators in adaptive evolution in the lab and in nature.
    Genetics. 1998 Apr;148(4):1559-66 PMID: 9560375
  139. Reversion of the tyrosine ochre strain Escherichia coli WU3610 under starvation conditions depends on a new gene tas.
    Genetics. 1998 Apr;148(4):1627-35 PMID: 9560382
  140. Adaptive mutagenesis at ebgR is regulated by PhoPQ.
    J Bacteriol. 1998 Jun;180(11):2862-5 PMID: 9603873
  141. DNA synthesis and viability of a mutT derivative of Escherichia coli WP2 under conditions of amino acid starvation and relation to stationary-phase (adaptive) mutation.
    J Bacteriol. 1998 Jun;180(11):2906-10 PMID: 9603880
  142. The role of DNA damage in stationary phase ('adaptive') mutation.
    Mutat Res. 1998 Jul;408(1):1-9 PMID: 9678058
  143. Adaptive mutagenesis: a process that generates almost exclusively beneficial mutations.
    Genetica. 1998;102-103(1-6):109-25 PMID: 9720275
  144. Effect of endogenous carotenoids and defective RpoS sigma factor on spontaneous mutation under starvation conditions in Escherichia coli: evidence for the possible involvement of singlet oxygen.
    Mutat Res. 1998 Jul 17;403(1-2):21-8 PMID: 9726002
  145. F- phenocopies: characterization of expression of the F transfer region in stationary phase.
    Microbiology. 1998 Sep;144 ( Pt 9):2579-87 PMID: 9782507
  146. Evidence that gene amplification underlies adaptive mutability of the bacterial lac operon.
    Science. 1998 Nov 6;282(5391):1133-5 PMID: 9804552
  147. Mutators in Escherichia coli.
    Mutat Res. 1998 Dec 14;409(3):99-106 PMID: 9875286
  148. Adaptive mutation of a lacZ amber allele.
    Genetics. 1998 Nov;150(3):1329-30 PMID: 9882191
  149. Diminishing returns from mutation supply rate in asexual populations.
    Science. 1999 Jan 15;283(5400):404-6 PMID: 9888858
  150. Spectra of spontaneous growth-dependent and adaptive mutations at ebgR.
    J Bacteriol. 1999 Feb;181(4):1149-55 PMID: 9973340
  151. Double-strand end repair via the RecBC pathway in Escherichia coli primes DNA replication.
    Genes Dev. 1999 Feb 1;13(3):345-56 PMID: 9990858
Article Info
Journal
Annual review of genetics
Abbr.
Annu Rev Genet
ISSN
0066-4197
DOI
10.1146/annurev.genet.33.1.57
Email
[email protected]
Published
1999-00-00
Pages
57-88
Language
English
Region
United States
NLM ID
0117605
PMCID
PMC2922758
Subset
IM
Grants
NIGMS NIH HHS · R01 GM054084-03 · United States
External Links
PubMed source DOI: 10.1146/annurev.genet.33.1.57 PMC Full Text View journal details
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