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PMID: 10786841 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Guilt by association: the arginine case revisited.

RNA (New York, N.Y.) ·Vol. 6 ·No. 4 ·2000-04-00 ·Pages 499-510

Knight RD, Landweber LF

Abstract

If the genetic code arose in an RNA world, present codon assignments may reflect primordial RNA-amino acid affinities. Whether aptamers selected from random pools to bind free amino acids do so using the cognate codons at their binding sites has been controversial. Here we defend and extend our previous analysis of arginine binding sites, and propose a model for the maintenance of codon-amino acid interactions through the evolution of amino acids from ribozyme cofactors into the building blocks of proteins.

MeSH Terms
Anticodon/chemistry,genetics,metabolism Arginine/genetics,metabolism Artifacts Base Composition Base Sequence Bias Binding Sites Codon/chemistry,genetics,metabolism Coenzymes/chemistry,genetics,metabolism Evolution, Molecular Genetic Code/genetics Ligands Models, Genetic Molecular Sequence Data Oligoribonucleotides/chemistry,genetics,metabolism RNA/chemistry,genetics,metabolism RNA, Catalytic/chemistry,genetics,metabolism Statistics as Topic Thermodynamics
Chemicals
Anticodon Codon Coenzymes Ligands Oligoribonucleotides RNA, Catalytic RNA Arginine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Knight R D
Department of Ecology and Evolutionary Biology, Princeton University, New Jersey 08544-1003, USA.
Landweber L F
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Article Info
Journal
RNA (New York, N.Y.)
Abbr.
RNA
ISSN
1355-8382
DOI
10.1017/s1355838200000145
Published
2000-04-00
Pages
499-510
Language
English
Region
United States
NLM ID
9509184
PMCID
PMC1369931
Subset
IM
External Links
PubMed source DOI: 10.1017/s1355838200000145 PMC Full Text View journal details
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