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PMID: 1079460 Published · ppublish ger English Abstract Journal Article

[Lymphocyte in chronic lymphatic leukemia].

Der Lymphozyt bei der chronischen lymphatischen Leukämie

Blut ·Vol. 30 ·No. 5 ·1975-05-00 ·Pages 293-308

Brittinger G, Augener W, Bremer K, Cohnen G, Dabag S, Fischer K, König E, Meusers P

Abstract

In patients with chronic lymphatic leukemia (CLL) the majority of peripheral blood lymphocytes was characterized as B cells by surface membrane markers. Ultrastructural studies revealed a reduction of the cytoplasmic area. Furthermore, the number of lysosomes was diminished corresponding to a decreased activity of lysosomal hydrolases. Increasing blood lymphocytosis was paralleled by an increase of the percentage of lysosome-poor lymphocytes. Response of CLL lymphocytes to in vitro stimulation with PHA and PWM was either lacking or diminished and/or delayed, and the number of transformed cells was reduced. Thus, the majority of CLL lymphocytes appears to represent both morphologically and functionally abnormal neoplastic b cells. During the early and later phase of stimulation the mitogen-reactive CLL lymphocytes exhibited alterations of the lysosomal apparatus similar to those observed in normal cells. The reactive lymphocytes may be derived from residual populations of normally functioning T and/or B cells. However, the neoplastic cells may also be able to respond to the mitogens. In vivo studies showed impaired kinetics of circulation and recirculation of CLL B lymphocytes, whereas the T cells were normal in this respect.

MeSH Terms
B-Lymphocytes/pathology Cytoplasm Humans Hydrolases Lectins Leukemia, Lymphoid/pathology Leukocyte Count Lymphocyte Activation Lymphocytes/enzymology,pathology Lysosomes Microscopy, Electron Surface Properties T-Lymphocytes/pathology Time Factors
Chemicals
Lectins Hydrolases
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Brittinger G
Augener W
Bremer K
Cohnen G
Dabag S
Fischer K
König E
Meusers P
References (51)
51 references, click to expand
  1. Studies on lysosomes. XII. Redistribution of acid hydrolases in human lymphocytes stimulated by phytohemagglutinin.
    J Cell Biol. 1968 May;37(2):412-23 PMID: 5656399
  2. Response to phytohaemagglutinin and pokeweed mitogen in chronic lymphocytic leukemia.
    Lancet. 1972 Apr 8;1(7754):794-6 PMID: 4111271
  3. [Lysosomal enzymes in lymphocytes. I. Lymphoreticular diseases: comparison of the enzyme content (acid phosphatase, beta-glucuronidase) in unstimulated lymphocytes with blastic transformation after stimulation with phytohemagglutinin beta-Glucuronidase in vitro].
    Acta Haematol. 1970;44(4):205-21 PMID: 4994270
  4. Immunoglobulins on the surface of lymphocytes. IV. Distribution in hypogammaglobulinemia, cellular immune deficiency, and chronic lymphatic leukemia.
    J Clin Invest. 1971 Nov;50(11):2368-75 PMID: 4999540
  5. Acid phosphatase cytochemistry of mitrogen-transformed normal and chronic lymphocytic leukemia lymphocytes.
    Exp Cell Res. 1973 Aug;80(2):297-304 PMID: 4745377
  6. Binding of concanavalin A to rat, normal human, and chronic lymphatic leukemia lymphocytes.
    Blood. 1972 Sep;40(3):311-6 PMID: 5056965
  7. Surface bound immunoglobulins as a cell marker in human lymphoproliferative diseases.
    Blood. 1972 Dec;40(6):777-94 PMID: 4628444
  8. Surface immunoglobulin-moieties on lymphoid cells.
    Exp Cell Res. 1970 Sep;62(1):133-48 PMID: 4991453
  9. Lymphocyte lysosomes and lysosomal enzymes in chronic lymphocytic leukemia.
    Blood. 1973 Apr;41(4):511-8 PMID: 4688866
  10. Immunoglobulins as cell receptors.
    Ann N Y Acad Sci. 1971 Dec 31;190:420-31 PMID: 4944965
  11. [Molecular biology of the lymphocyte of the chronic lymphocytic leukemia (author's transl)].
    Klin Wochenschr. 1974 Dec 1;52(23):1093-102 PMID: 4613945
  12. Clinical significance of T-cells in chronic lymphocytic leukaemia.
    Lancet. 1974 Sep 28;2(7883):751-2 PMID: 4143015
  13. Isolation of normal T cells in chronic lymphatic leukaemia.
    Lancet. 1973 Jan 20;1(7795):126-9 PMID: 4118467
  14. Immunoglobulins on the surface of human lymphocytes.
    Lancet. 1971 Oct 16;2(7729):850-2 PMID: 4106875
  15. Impaired recirculation of autotransfused blood lymphocytes via thoracic duct lymph in patients with chronic lymphoid leukemia.
    Biomedicine. 1973 Sep;18(5):393-400 PMID: 4800554
  16. Impaired pentose phosphate shunt and decreased glycolytic activity in lymphocytes of chronic lymphocytic leukemia. Metabolic pathway.
    Blood. 1969 Oct;34(4):421-9 PMID: 5821751
  17. Membrane immunoglobulins of B lymphocytes: inability to detect certain characteristic IgM and IgD antigens.
    J Exp Med. 1974 Oct 1;140(4):895-903 PMID: 4139226
  18. Surface structure of normal and leukaemic lymphocytes. I. Effect of mitogens.
    Clin Exp Immunol. 1972 Apr;10(4):555-70 PMID: 5034244
  19. Decreased phytohemagglutinin receptor sites in chronic lymphocytic leukemia.
    Biochim Biophys Acta. 1969 Dec 30;192(3):542-5 PMID: 5368257
  20. Response of lymphocytes in chronic lymphocytic leukaemia to plant mitogens.
    Lancet. 1972 Jan 29;1(7744):229-33 PMID: 4109700
  21. Impaired recirculation of B lymphocytes in chronic lymphocytic leukemia.
    Eur J Immunol. 1973 Nov;3(11):688-93 PMID: 4129486
  22. In vitro stimulation of chronic lymphocytic leukaemic lymphocytes.
    Br J Haematol. 1974 Jun;27(2):289-96 PMID: 4526426
  23. Kinetics of lymphocytes in chronic lymphocytic leukemia: studies using continuous 3H-thymidine infusion in two patients.
    Blood. 1973 Oct;42(4):623-36 PMID: 4778708
  24. Lymphocyte surface markers in lymphoproliferative disorders.
    Acta Haematol. 1973;50(5):275-83 PMID: 4202631
  25. IMMUNOLOGIC DEFICIENCY DISORDERS ASSOCIATED WITH LYMPHOPROLIFERATIVE DISEASES.
    Semin Hematol. 1965 Jan;2:47-67 PMID: 14268737
  26. Rosetting of human red blood cells to thymocytes and thymus-derived cells.
    Clin Exp Immunol. 1973 Nov;15(3):385-92 PMID: 4202949
  27. Identification of human T and B lymphocytes in normal peripheral blood and in chronic lymphocytic leukaemia.
    Lancet. 1971 Oct 9;2(7728):788-91 PMID: 4106607
  28. Protein synthesis by ribosomes from blood lymphocytes of normals and patients with chronic lymphocytic leukemia (CLL).
    Proc Soc Exp Biol Med. 1972 Dec;141(3):839-41 PMID: 4645769
  29. Relation of lysosomal fragility in CLL lymphocytes to PHA reactivity.
    Nat New Biol. 1973 Aug 22;244(138):247-8 PMID: 4516602
  30. IgD: a major immunoglobulin on the surface of lymphocytes from patients with chronic lymphatic leukemia.
    J Immunol. 1974 May;112(5):1952-4 PMID: 4594421
  31. [Immunological markers in the differential diagnosis of systemic lymphatic diseases (author's transl)].
    Dtsch Med Wochenschr. 1974 Nov 8;99(45):2262-8 PMID: 4548666
  32. The response to plant mitogens of two subpopulations of lymphocytes in a case of chronic lymphocytic leukaemia.
    Clin Exp Immunol. 1973 Jul;14(3):397-408 PMID: 4353488
  33. Binding of aggregated IgG by lymphocytes in chronic lymphocytic leukemia.
    Biomedicine. 1974 Jan 20;21(1):6-8 PMID: 4602945
  34. Effects of phytohemagglutinin and isoproterenol on DNA synthesis in lymphocytes from normal donors and patients with chronic lymphocytic leukemia.
    Cancer Res. 1970 Mar;30(3):717-23 PMID: 5425294
  35. Membrane dynamics of HL-A-anti-HL-A complexes of human normal and leukaemic lymphocytes.
    Clin Exp Immunol. 1973 May;14(1):57-67 PMID: 4123743
  36. [Recirculation of lymphocytes in patients with malignant lymphatic systemic diseases].
    Blut. 1972 Apr;24(4):215-25 PMID: 5067297
  37. Immunological characterization of lymphocytes in lymphoproliferative diseases. Restriction of classes, subclasses, and Gm allotypes of membrane-bound Ig.
    Scand J Immunol. 1972;1(4):351-60 PMID: 4590280
  38. IMMUNOLOGIC AND CYTOGENETIC STUDIES OF CHRONIC LYMPHOCYTIC LEUKEMIC CELLS.
    Blood. 1965 Aug;26:121-32 PMID: 14332475
  39. Heterogeneity of 5'-nucleotidase activity in lymphocytes in chronic lymphocytic leukemia.
    J Clin Invest. 1973 May;52(5):1297-300 PMID: 4700498
  40. Expression of human T and B lymphocyte cell-surface markers on leukaemic cells.
    Lancet. 1974 Sep 28;2(7883):753-5 PMID: 4143016
  41. Electron microscopic and functional aspects of human lymphocyte response to mitogens.
    Transplant Rev. 1972;11:39-59 PMID: 4588911
  42. Lymphocyte binding of aggregated IgG and surface Ig staining in chronic lymphocytic leukaemia.
    Clin Exp Immunol. 1973 May;14(1):97-106 PMID: 4577289
  43. Studies of human peripheral lymph. II. Low lymphocyte count and few B-lymphocytes in peripheral lymph of patients with chronic lymphocytic leukaemia.
    Scand J Haematol. 1974;13(2):93-100 PMID: 4547504
  44. Redistribution of immunoglobulin determinants on human lymphocytes in lymphoproliferative disorders.
    Eur J Cancer. 1974 Aug;10(8):517-21 PMID: 4142759
  45. Human lymphocyte-sheep erythrocyte rosette formation: some characteristics of the interaction.
    Clin Immunol Immunopathol. 1973 Jul;1(4):511-22 PMID: 4549205
  46. Immunoglobulins on the surface of neoplastic lymphocytes.
    N Engl J Med. 1972 Aug 10;287(6):272-6 PMID: 4556902
  47. Rosette-forming lymphocytes in normals and patients with malignant lymphomas.
    Acta Haematol. 1974;51(2):65-75 PMID: 4217078
  48. Studies of the delayed response of phytohemagglutinin (PHA) stimulated lymphocytes in 25 chronic lymphatic leukemia patients before and during therapy.
    Blood. 1969 Aug;34(2):166-78 PMID: 5794114
  49. DNA repair in human leukaemic lymphocytes.
    Nat New Biol. 1972 Nov 22;240(99):114-6 PMID: 4509023
  50. Kinetic differences of autotransfused 3 H-cytidine labeled blood lymphocytes in leukemic and non-leukemic lymphoma patients.
    Eur J Cancer. 1973 Feb;9(2):113-24 PMID: 4577732
  51. Combined studies of complement receptor and surface immunoglobulin-bearing cells and sheep erythrocyte rosette-forming cells in normal and leukemic human lymphocytes.
    J Clin Invest. 1973 Feb;52(2):377-85 PMID: 4567307
Article Info
Journal
Blut
Abbr.
Blut
ISSN
0006-5242
DOI
10.1007/BF01633649
Published
1975-05-00
Pages
293-308
Language
ger
Region
Germany
NLM ID
0173401
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01633649
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