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PMID: 1086064 Published · ppublish English Comparative Study Journal Article

Ultrastructural study of Reed-Sternberg cells. Comparison with transformed lymphocytes and histiocytes.

The American journal of pathology ·Vol. 85 ·No. 1 ·1976-10-00 ·Pages 195-208

Glick AD, Leech JH, Flexner JM, Collins RD

Abstract

The ultrastructural features of Reed-Sternberg cells from 17 patients with Hodgkin's disease were compared with those of histiocytes and transformed lymphocytes in both benign and malignant conditions. Transformed lymphocytes and Reed-Sternberg cells appeared to have similar features, including large nuclei with dispersed chromatin, large nucleoli, and great numbers of cytoplasmic polyribosomes. Histiocytes contained abundant cytoplasmic lysosomal granules and microfilaments. These results are indicative of the origin of Reed-Sternberg cells from lymphocytes.

MeSH Terms
B-Lymphocytes/ultrastructure Cell Nucleolus/ultrastructure Cytoplasm/ultrastructure Histiocytes/ultrastructure Hodgkin Disease/pathology Humans Lymphocyte Activation Lymphocytes/ultrastructure Lymphoma/pathology T-Lymphocytes/ultrastructure
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Glick A D
Leech J H
Flexner J M
Collins R D
References (12)
12 references, click to expand
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1976-10-00
Pages
195-208
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC2032544
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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