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PMID: 10991906 Published · ppublish English Journal Article Review

5-hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension.

British journal of pharmacology ·Vol. 131 ·No. 2 ·2000-09-00 ·Pages 161-8

MacLean MR, Herve P, Eddahibi S, Adnot S

Abstract

暂无摘要

MeSH Terms
Humans Hypertension, Pulmonary/metabolism Pulmonary Artery/physiology Pulmonary Circulation/physiology Receptors, Serotonin/metabolism Serotonin/physiology Vasoconstriction
Chemicals
Receptors, Serotonin Serotonin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
MacLean M R
Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, G12 8QQ. UPRES.
Herve P
Eddahibi S
Adnot S
References (69)
69 references, click to expand
  1. Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin.
    Circ Res. 1999 Feb 19;84(3):329-36 PMID: 10024307
  2. Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension.
    Am J Respir Crit Care Med. 1999 Jun;159(6):1925-32 PMID: 10351941
  3. Cardiopulmonary dysfunction in cirrhosis.
    J Gastroenterol Hepatol. 1999 Jun;14(6):600-8 PMID: 10385072
  4. EVE and beyond, retro and prospective insights.
    Am J Physiol. 1999 Jul;277(1 Pt 1):L5-12 PMID: 10409225
  5. 5-Hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats.
    Br J Pharmacol. 1996 Nov;119(5):917-30 PMID: 8922741
  6. Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell-specific markers. Evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth.
    Am J Pathol. 1999 Aug;155(2):411-9 PMID: 10433934
  7. Endothelin-1 and serotonin: mediators of primary and secondary pulmonary hypertension?
    J Lab Clin Med. 1999 Aug;134(2):105-14 PMID: 10444023
  8. Synergistic interactions between fenfluramine and phentermine.
    Int J Obes Relat Metab Disord. 1999 Jul;23(7):723-32 PMID: 10454106
  9. 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor.
    Br J Pharmacol. 1999 Oct;128(3):730-4 PMID: 10516655
  10. Pulmonary hypertension, anorexigens and 5-HT: pharmacological synergism in action?
    Trends Pharmacol Sci. 1999 Dec;20(12):490-5 PMID: 10603491
  11. Anorexigens and pulmonary hypertension in the United States: results from the surveillance of North American pulmonary hypertension.
    Chest. 2000 Mar;117(3):870-4 PMID: 10713017
  12. Cell-specific differences in ET-1 system in adjacent layers of main pulmonary artery. A new source of ET-1.
    Am J Physiol Lung Cell Mol Physiol. 2000 Apr;278(4):L813-21 PMID: 10749759
  13. Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene.
    J Clin Invest. 2000 Jun;105(11):1555-62 PMID: 10841514
  14. Imbalance between platelet vascular endothelial growth factor and platelet-derived growth factor in pulmonary hypertension. Effect of prostacyclin therapy.
    Am J Respir Crit Care Med. 2000 Oct;162(4 Pt 1):1493-9 PMID: 11029367
  15. Aminorex and the pulmonary circulation.
    Thorax. 1971 May;26(3):262-70 PMID: 5089490
  16. Effect of fenfluramine on 5-hydroxytryptamine uptake and release by rat blood platelets.
    Br J Pharmacol. 1975 Apr;53(4):563-8 PMID: 1148499
  17. On the role of serotonin in the pathogenesis of pulmonary hypertension induced by anorectic drugs; an experimental study in the isolated perfused rat lung, II. Fenfluramine, mazindol, mefenorex, phentermine and R 800.
    Clin Exp Pharmacol Physiol. 1976 Jul-Aug;3(4):323-30 PMID: 975621
  18. Red blood cells play a crucial role in maintaining vascular reactivity to hypoxia in isolated rat lungs.
    Chest. 1977 Feb;71(2 suppl):253-6 PMID: 836363
  19. Release of platelet 5-hydroxytryptamine by some anorexic and other sympathomimetics and their acetyl derivatives.
    Acta Pharmacol Toxicol (Copenh). 1977 Sep;41(3):218-24 PMID: 578650
  20. Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features.
    Am J Physiol. 1979 Jun;236(6):H818-27 PMID: 443445
  21. The role of the renin-angiotensin and natriuretic peptide systems in the pulmonary vasculature.
    Br J Clin Pharmacol. 1995 Jul;40(1):11-8 PMID: 8527262
  22. Contractile responses to sumatriptan in isolated bovine pulmonary artery rings: relationship to tone and cyclic nucleotide levels.
    J Cardiovasc Pharmacol. 1995 Nov;26(5):751-60 PMID: 8637190
  23. Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International Primary Pulmonary Hypertension Study Group.
    N Engl J Med. 1996 Aug 29;335(9):609-16 PMID: 8692238
  24. Effects of dexfenfluramine or 5,7-dihydroxytryptamine on tryptophan hydroxylase and serotonin transporter mRNAS in rat dorsal raphe.
    Brain Res Mol Brain Res. 1996 Sep 5;41(1-2):121-7 PMID: 8883942
  25. Evidence for 5-HT1-like receptor-mediated vasoconstriction in human pulmonary artery.
    Br J Pharmacol. 1996 Sep;119(2):277-82 PMID: 8886409
  26. EndothelinB receptor-mediated contraction in human pulmonary resistance arteries.
    Br J Pharmacol. 1996 Nov;119(6):1125-30 PMID: 8937714
  27. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1.
    J Biol Chem. 1996 Dec 20;271(51):32529-37 PMID: 8955077
  28. Increased turnover of serotonin in children with pulmonary hypertension secondary to congenital heart disease.
    Pediatr Cardiol. 1996 Jul-Aug;17(4):214-9 PMID: 8662042
  29. Association of Tyr phosphorylation of GTPase-activating protein with mitogenic action of serotonin.
    Am J Physiol. 1997 Jan;272(1 Pt 1):C223-30 PMID: 9038828
  30. Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32.
    Nat Genet. 1997 Mar;15(3):277-80 PMID: 9054941
  31. Serotonin receptors subserve only contraction in canine and rat pulmonary arteries and veins.
    Artery. 1980;7(3):232-45 PMID: 7469796
  32. Pulmonary hypertension. Anatomic and physiologic correlates.
    Clin Chest Med. 1983 May;4(2):199-217 PMID: 6342920
  33. Stimulation of aortic smooth muscle cell mitogenesis by serotonin.
    Proc Natl Acad Sci U S A. 1986 Feb;83(3):674-8 PMID: 3456163
  34. Comparative effects of oxygen, nifedipine and ketanserin in hypoxic pulmonary hypertension.
    Cor Vasa. 1985;27(6):406-11 PMID: 2936568
  35. The pathology of the early and late stages of primary pulmonary hypertension.
    Br Heart J. 1987 Sep;58(3):204-13 PMID: 3663419
  36. Pulmonary neuroendocrine cells. Their secretory products and their potential roles in health and chronic lung disease in infancy.
    Am Rev Respir Dis. 1989 Dec;140(6):1807-12 PMID: 2574971
  37. Primary pulmonary hypertension in a patient with a familial platelet storage pool disease: role of serotonin.
    Am J Med. 1990 Jul;89(1):117-20 PMID: 2368783
  38. Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease?
    Ann Intern Med. 1991 Mar 15;114(6):464-9 PMID: 1994793
  39. Dual effect of serotonin on growth of bovine pulmonary artery smooth muscle cells in culture.
    Circ Res. 1991 May;68(5):1362-8 PMID: 1850332
  40. Paradoxical constriction to platelets by arteries from rats with pulmonary hypertension.
    Am J Physiol. 1991 Jun;260(6 Pt 2):H1929-34 PMID: 1829334
  41. Evidence for a storage pool defect in platelets from cirrhotic patients with defective aggregation.
    Gastroenterology. 1992 Aug;103(2):641-6 PMID: 1386051
  42. Simultaneous effects of p-chloroamphetamine, d-fenfluramine, and reserpine on free and stored 5-hydroxytryptamine in brain and blood.
    J Neurochem. 1992 Sep;59(3):1138-44 PMID: 1379630
  43. The effect of i.v. sumatriptan, a selective 5-HT1-receptor agonist on central haemodynamics and the coronary circulation.
    Br J Clin Pharmacol. 1992 Dec;34(6):541-6 PMID: 1337261
  44. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
    Proc Natl Acad Sci U S A. 1993 May 1;90(9):4304-8 PMID: 8387214
  45. Endothelial control of the pulmonary circulation in normal and chronically hypoxic rats.
    J Physiol. 1993 Apr;463:1-16 PMID: 8246176
  46. Chronic hypoxia is associated with reduced delayed rectifier K+ current in rat pulmonary artery muscle cells.
    Am J Physiol. 1994 Jan;266(1 Pt 2):H365-70 PMID: 8304521
  47. Serotonin increases DNA synthesis in rat proximal and distal pulmonary vascular smooth muscle cells in culture.
    Am J Physiol. 1994 Feb;266(2 Pt 1):L178-86 PMID: 8141313
  48. 5-HT1-receptor-mediated vasoconstriction in bovine isolated pulmonary arteries: influences of vascular endothelium and tone.
    Pulm Pharmacol. 1994 Feb;7(1):65-72 PMID: 7516208
  49. Endothelin ETA- and ETB-receptor-mediated vasoconstriction in rat pulmonary arteries and arterioles.
    J Cardiovasc Pharmacol. 1994 May;23(5):838-45 PMID: 7521470
  50. Multiple phenotypically distinct smooth muscle cell populations exist in the adult and developing bovine pulmonary arterial media in vivo.
    Circ Res. 1994 Oct;75(4):669-81 PMID: 7923613
  51. Organization of the human serotonin transporter gene.
    J Neural Transm Gen Sect. 1994;95(2):157-62 PMID: 7865169
  52. The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels.
    FASEB J. 1995 Feb;9(2):183-9 PMID: 7781921
  53. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension.
    N Engl J Med. 1995 Jul 27;333(4):214-21 PMID: 7540722
  54. Increased plasma serotonin in primary pulmonary hypertension.
    Am J Med. 1995 Sep;99(3):249-54 PMID: 7653484
  55. Treatment with 5-HT potentiates development of pulmonary hypertension in chronically hypoxic rats.
    Am J Physiol. 1997 Mar;272(3 Pt 2):H1173-81 PMID: 9087590
  56. A new role for an old molecule: serotonin as a mitogen.
    Am J Physiol. 1997 May;272(5 Pt 1):L795-806 PMID: 9176241
  57. Valvular heart disease associated with fenfluramine-phentermine.
    N Engl J Med. 1997 Aug 28;337(9):581-8 PMID: 9271479
  58. Potassium channel diversity in vascular smooth muscle cells.
    Can J Physiol Pharmacol. 1997 Jul;75(7):889-97 PMID: 9315358
  59. Phosphodiesterase isoforms in the pulmonary arterial circulation of the rat: changes in pulmonary hypertension.
    J Pharmacol Exp Ther. 1997 Nov;283(2):619-24 PMID: 9353377
  60. 5-Lipoxygenase and 5-lipoxygenase activating protein (FLAP) immunoreactivity in lungs from patients with primary pulmonary hypertension.
    Am J Respir Crit Care Med. 1998 Jan;157(1):219-29 PMID: 9445303
  61. Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension.
    J Clin Invest. 1998 Mar 1;101(5):927-34 PMID: 9486960
  62. Haemodynamic effects of ketanserin either alone or with oxygen in COPD patients with secondary pulmonary hypertension.
    Monaldi Arch Chest Dis. 1997 Oct;52(5):429-33 PMID: 9510660
  63. Effect of dexfenfluramine treatment in rats exposed to acute and chronic hypoxia.
    Am J Respir Crit Care Med. 1998 Apr;157(4 Pt 1):1111-9 PMID: 9563727
  64. Signaling pathways mediating induction of the early response genes prostaglandin G/H synthase-2 and egr-1 by serotonin via 5-HT2A receptors.
    J Cell Physiol. 1998 Jun;175(3):341-7 PMID: 9572479
  65. Superoxide as an intermediate signal for serotonin-induced mitogenesis.
    Free Radic Biol Med. 1998 Mar 15;24(5):855-8 PMID: 9586816
  66. Influence of chronic hypoxia on the contributions of non-inactivating and delayed rectifier K currents to the resting potential and tone of rat pulmonary artery smooth muscle.
    Br J Pharmacol. 1998 Aug;124(7):1335-7 PMID: 9723941
  67. Lipid mediator dysregulation in primary pulmonary hypertension.
    Chest. 1998 Sep;114(3 Suppl):205S-207S PMID: 9741570
  68. Etiology and pathogenesis of primary pulmonary hypertension: a perspective.
    Chest. 1998 Sep;114(3 Suppl):242S-247S PMID: 9741576
  69. Dysfunctional voltage-gated K+ channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension.
    Circulation. 1998 Oct 6;98(14):1400-6 PMID: 9760294
Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
Published
2000-09-00
Pages
161-8
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1572323
Subset
IM
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