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PMID: 7865169 Published · ppublish English Journal Article

Organization of the human serotonin transporter gene.

Journal of neural transmission. General section ·Vol. 95 ·No. 2 ·1994-00-00 ·Pages 157-62

Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, Riederer P

Abstract

The gene encoding the human serotonin transporter (5-HTT) has been isolated and characterized. The human 5-HTT gene is composed of 14 exons spanning approximately 31 kb. The sequence of all exons including adjacent intronic sequences and a tandem repeat DNA polymorphism (VNTR) has been determined and deposited in the EMBL/GenBank data base with the accession numbers X76753 to X76762. The characterization of 5-HTT gene will aid to advance molecular pharmacologic studies of 5-HT uptake regulation and facilitate investigations of its role in psychiatric disorders.

MeSH Terms
Base Sequence Carrier Proteins/genetics DNA, Complementary/genetics Exons Genes Humans Introns Membrane Glycoproteins/genetics Membrane Transport Proteins Mental Disorders/genetics Minisatellite Repeats Molecular Sequence Data Nerve Tissue Proteins/genetics Serotonin/metabolism Serotonin Plasma Membrane Transport Proteins
Chemicals
Carrier Proteins DNA, Complementary Membrane Glycoproteins Membrane Transport Proteins Nerve Tissue Proteins SLC6A4 protein, human Serotonin Plasma Membrane Transport Proteins Serotonin
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Lesch K P
Department of Psychiatry, University of Würzburg, Federal Republic of Germany.
Balling U
Gross J
Strauss K
Wolozin B L
Murphy D L
Riederer P
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Article Info
Journal
Journal of neural transmission. General section
Abbr.
J Neural Transm Gen Sect
DOI
10.1007/BF01276434
Published
1994-00-00
Pages
157-62
Language
English
Region
Austria
NLM ID
9002201
Subset
IM
Databases
GENBANK
X76753, X76762
External Links
PubMed source DOI: 10.1007/BF01276434
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