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PMID: 1102427 Published · ppublish English Journal Article Review

Recent developments in foetal haemoglobin research.

Humangenetik ·Vol. 30 ·No. 3 ·1975-09-20 ·Pages 197-205

Kamuzora H

Abstract

There have been numerous new contributions to the knowledge of foetal haemoglobin over the last few years. It is, therefore, timely to review them together. They throw light on the arrangement on the chromosome of non-alpha chain genes, and on the condition generally known as Hereditary Persistence of Foetal Haemoglobin (HPFH) and have contributed to other aspects of human ontogeny and physiology.

MeSH Terms
Adult Amino Acid Sequence Anemia, Aplastic/blood Anemia, Sickle Cell/blood Child Erythrocytes/analysis Erythropoietin/pharmacology Female Fetal Blood/metabolism Fetal Hemoglobin/analysis,biosynthesis Genes Genetic Linkage Genetic Variation Genetics, Population Hemoglobinopathies/blood Humans Infant Infant, Newborn Leukemia/blood Oxygen/blood Pregnancy Protein Denaturation Suppression, Genetic Thalassemia/blood
Chemicals
Erythropoietin Fetal Hemoglobin Oxygen
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kamuzora H
References (53)
53 references, click to expand
  1. Studies on human foetal haemoglobin. II. Foetal haemoglobin levels in healthy children and adults and in certain haematological disorders.
    Br J Haematol. 1960 Jul;6:201-22 PMID: 13688329
  2. The present status of the heterogeneity of fetal hemoglobin in beta-thalassemia: an attempt to unify some observations in thalassemia and related conditions.
    Ann N Y Acad Sci. 1974;232(0):107-24 PMID: 4528800
  3. Haemoglobin F Jamaica (alpha-2 gamma-2 61 Lys leads to Glu; 136 Ala).
    Br J Haematol. 1970 Mar;18(3):369-75 PMID: 5491586
  4. Molecular basis of morbidity from a series of studies of hemoglobinopathies in Western Japan.
    Jinrui Idengaku Zasshi. 1968 Jul;13(1):40-53 PMID: 5750181
  5. Evidence of various types of synthesis of human gamma chains of haemoglobin in acquired haematological disorders.
    Nat New Biol. 1971 Sep 22;233(38):111-3 PMID: 5285964
  6. An adult homozygous for persistent fetal hemoglobin.
    Ann Intern Med. 1970 Apr;72(4):533-6 PMID: 5437636
  7. Haemoglobin F Port Royal (alpha2G gamma2 125 Glu leads to Ala).
    Br J Haematol. 1974 Jun;27(2):313-8 PMID: 4846278
  8. A Ghanaian adult, homozygous for hereditary persistence of foetal haemoglobin and heterozygous for elliptocytosis.
    Acta Haematol. 1970;43(2):100-10 PMID: 4986189
  9. Haemoglobin F Malaysia: alpha 2, gamma 2 1(NA1) glycine--cysteine; 136 glycine.
    J Med Genet. 1974 Mar;11(1):25-30 PMID: 4837284
  10. Carbonic anhydrase and fetal hemoglobin in tyrotoxicosis.
    Blood. 1967 Oct;30(4):442-8 PMID: 4964168
  11. Evidence for multiple structural genes for the gamma-chain of human fetal hemoglobin in hereditary persistence of fetal hemoglobin.
    Ann N Y Acad Sci. 1969 Nov 20;165(1):320-31 PMID: 5260154
  12. Prognostic value of fetal hemoglobin levels in acquired aplastic anemia.
    N Engl J Med. 1968 Feb 8;278(6):304-7 PMID: 5638348
  13. Estimation of foetal haemoglobin in leukaemia.
    Acta Haematol. 1966 Apr;35(4):214-20 PMID: 4959172
  14. Hemoglobin synthesis in short-term cultures of human fetal hematopoietic tissues.
    Blood. 1972 Apr;39(4):530-41 PMID: 5011978
  15. The mortality of acquired aplastic anemia in children.
    Blood. 1972 Aug;40(2):153-62 PMID: 5044585
  16. Hemoglobin "pylos": study of a hemoglobinopathy resembling thalassemia in the heterozygous, homozygous and double heterozygous state.
    Blood. 1962 Jan;19:1-22 PMID: 13892631
  17. Chemical heterogeneity of fetal hemoglobin in subjects with sickle cell anemia, homozygous Hb-C disease, SC disease, and various combinations of hemoglobin variants.
    Clin Chim Acta. 1972 Apr;38(1):5-16 PMID: 5031797
  18. Maternal synthesis of haemoglobin F in pregnancy.
    Lancet. 1973 Jun 16;1(7816):1350-4 PMID: 4122742
  19. Evidence for four nonallelic structural genes for the chain of human fetal hemoglobin.
    Biochem Genet. 1972 Oct;7(2):131-9 PMID: 5050916
  20. Benign sickle-cell anaemia.
    Lancet. 1972 Dec 2;2(7788):1163-7 PMID: 4117591
  21. Haemoglobin synthesis in suspension cultures of human bone marrow.
    Br J Haematol. 1974 Mar;26(3):451-8 PMID: 4852212
  22. Hereditary persistence of foetal haemoglobin associated with a gamma beta fusion variant, haemoglobin Kenya.
    Nat New Biol. 1973 Dec 12;246(154):184-6 PMID: 4519001
  23. Hemoglobin Kenya, the product of fusion of amd polypeptide chains.
    Arch Biochem Biophys. 1972 Dec;153(2):850-3 PMID: 4676910
  24. Futher investigations of the gamma-chaina in a ghanaian adult, homozygous for hereditary perisitence of fetal haemoglobin. Isolation of gamma CB-3 peptides and Ggamma:Agamma ratio determination in human Hb E.
    Acta Haematol. 1975;53(5):315-20 PMID: 808072
  25. Hemoglobin synthesis during amphibian metamorphosis. II. Synthesis of adult hemoglobin following thyroxine administration.
    J Mol Biol. 1968 Mar 28;32(3):493-502 PMID: 5644918
  26. A form of hereditary persistence of fetal haemoglobin characterized by uneven cellular distribution of haemoglobin F and the production of haemoglobins A and A2 in homozygotes.
    Br J Haematol. 1975 Feb;29(2):205-20 PMID: 811241
  27. Alkali-resistant hemoglobin in aplastic anemia of both acquired and congenital types.
    N Engl J Med. 1962 Jan 18;266:117-20 PMID: 13911138
  28. Relatively benign sickle-cell anaemia in 60 patients aged over 30 in the West Indies.
    Br Med J. 1968 Jul 13;3(5610):86-91 PMID: 4232783
  29. Haemoglobin F(Malta): a new foetal haemoglobin variant with a high incidence in Maltese infants.
    Nature. 1969 Jul 19;223(5203):311-3 PMID: 5792729
  30. Changes in the haemoglobin types of sheep as a response to anaemia.
    Biochem J. 1964 Nov;93(2):401-9 PMID: 5838667
  31. Hemoglobin Kenya, the product of a gamma-beta fusion gene: studies of the family.
    Am J Hum Genet. 1973 Sep;25(5):548-63 PMID: 4741849
  32. Hemoglobin switching in sheep and goats: change in functional globin messenger RNA in reticulocytes and bone marrow cells.
    Proc Natl Acad Sci U S A. 1972 Aug;69(8):2184-8 PMID: 4506088
  33. THE AMINO ACID SEQUENCE OF THE GAMMA CHAIN OF HUMAN FETAL HEMOGLOBIN.
    Biochemistry. 1963 Sep-Oct;2:992-1008 PMID: 14087393
  34. Balanced globin chain synthesis in hereditary persistence of fetal hemoglobin.
    J Clin Invest. 1974 Aug;54(2):433-8 PMID: 4847253
  35. A new Hb variant: Hb F Sardinia gamma75(E19) isoleucine leads to threonine found in a family with Hb G Philadelphia, beta-chain deficiency and a Lepore-like haemoglobin indistinguishable from Hb A2.
    Acta Haematol. 1975;53(6):347-55 PMID: 808940
  36. Semi-quantitative estimation of the distribution of fetal hemoglobin in red cell populations.
    Bull Johns Hopkins Hosp. 1962 Jun;110:293-310 PMID: 13911663
  37. Production of foetal haemoglobin in marrow cultures of human adults.
    Nature. 1968 Feb 10;217(5128):569-71 PMID: 5641113
  38. Multiple cistrons for fetal hemoglobin in man.
    Ann N Y Acad Sci. 1974 Nov 29;241(0):70-9 PMID: 4530691
  39. Hereditary persistence of fetal hemoglobin: a study of 79 affected persons in 15 Negro families in Baltimore.
    Blood. 1963 Mar;21:261-81 PMID: 14022587
  40. The gamma-chain in a Ghanaian adult, homozygous for hereditary persistence of fetal haemoglobin.
    Acta Haematol. 1974;51(3):179-84 PMID: 4218432
  41. FETAL HAEMOGLOBIN IN ACQUIRED APLASTIC ANAEMIA.
    Acta Haematol. 1964 Sep;32:188-92 PMID: 14227137
  42. Mechanism of denaturation of haemoglobin by alkali.
    Nature. 1974 Feb 8;247(5440):341-4 PMID: 4206361
  43. GRANULOCYTIC LEUKAEMIA IN CHILDHOOD.
    Br J Haematol. 1964 Oct;10:551-66 PMID: 14218457
  44. A child homozygous for persistence of fetal haemoglobin.
    Nature. 1963 Jun 22;198:1177-9 PMID: 13968951
  45. The formation of foetal and adult haemoglobin in cell cultures of neonatal calf marrow.
    Br J Haematol. 1970 Nov;19(5):621-33 PMID: 4098212
  46. Milder variant of sickle-cell disease in Arabs in Kuwait associated with unusually high level of foetal haemoglobin.
    Br J Haematol. 1970 Nov;19(5):613-9 PMID: 5481506
  47. [Fetal and residual hemoglobin in the erythrocytes and erythroblasts of human fetuses and newborn infants].
    Blut. 1958 Nov;4(5):241-9 PMID: 13607582
  48. Haemoglobin and red cell enzyme changes in juvenile myeloid leukaemia.
    Br Med J. 1968 Mar 16;1(5593):679-81 PMID: 4966603
  49. Acquired macrocytic anemia and hemoglobinopathy--a paraneoplastic manifestation?
    Am J Med. 1970 Jun;48(6):792-7 PMID: 5420567
  50. Haemoglobin F Hull (gamma-121 glutamic acid--lysine), homologous with haemoglobins O Arab and O Indonesia.
    Br Med J. 1967 Aug 26;3(5564):531-3 PMID: 6038320
  51. Haemoglobin F Texas I(alpha-2,gamma-2-5glu-lys): a variant of haemoglobin F.
    Br J Haematol. 1967 Mar;13(2):252-5 PMID: 6019034
  52. Evidence for multiple structural genes for the gamma chain of human fetal hemoglobin.
    Proc Natl Acad Sci U S A. 1968 Jun;60(2):537-44 PMID: 5248810
  53. Study of nine families with haemoglobin-Lepore.
    Br J Haematol. 1968 Aug;15(2):161-72 PMID: 5675530
Article Info
Journal
Humangenetik
Abbr.
Humangenetik
ISSN
0018-7348
DOI
10.1007/BF00279185
Published
1975-09-20
Pages
197-205
Language
English
Region
Germany
NLM ID
7607154
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00279185
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