Abstract
The fungal metabolite ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase, has been shown to be significantly effective in lowering serum cholesterol levels in cynomolgus monkeys at doses of 20-50 mg/kg per day. Levels of serum phospholipids and triglycerides were, however, not significantly changed by the administration of the drug. Of the serum lipoprotein fractions, a beta-lipoprotein corresponding to low density lipoprotein was preferentially reduced by the drug treatment. Fecal excretion of neutral sterols was unaffected but that of bile acids and slightly elevated by the administration of ML-236B.
MeSH Terms
Animals
Anticholesteremic Agents/pharmacology
Bile Acids and Salts/metabolism
Cholesterol/blood
Feces/analysis
Female
Haplorhini
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Lipoproteins/blood
Macaca fascicularis
Male
Sterols/metabolism
Triglycerides/blood
Chemicals
Anticholesteremic Agents
Bile Acids and Salts
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Lipoproteins
Sterols
Triglycerides
Cholesterol
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kuroda M
Tsujita Y
Tanzawa K
Endo A
References (10)
10 references, click to expand
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PMID: 14336211
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ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium.
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Hypolipidemic effects in dogs of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
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PMID: 4709118
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Inhibitory effects on lipid metabolism in cultured cells of ML-236B, a potent inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase.
Eur J Biochem. 1978 Jun 15;87(2):313-21
PMID: 668696
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Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity.
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PMID: 16386050
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An overview of the biochemical pharmacology of probucol.
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PMID: 189154
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Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Eur J Biochem. 1977 Jul 1;77(1):31-6
PMID: 908337