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PMID: 11122775 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Atherosclerosis and diabetes: the RAGE connection.

Current atherosclerosis reports ·Vol. 2 ·No. 5 ·2000-09-00 ·Pages 430-6

Schmidt AM, Stern D

Abstract

Diabetes mellitus begins as a disorder of glucose metabolism that progressively compromises the function of virtually every organ system as the secondary complications inexorably develop. The quality of life for patients with diabetes is diminished by the consequences of these complications. Accelerated and aggressive atherosclerosis is the greatest cause of morbidity and mortality with diabetes, emphasizing the importance of determining underlying mechanisms. This review highlights the role of the multiligand receptor for advanced glycation endproducts (RAGE) and two of its ligands, advanced glycation endproducts (AGEs) and S100/calgranulins, in the pathogenesis of atherosclerosis associated with diabetes. The results of the studies reviewed herein suggest that RAGE is a potential therapeutic target for macrovascular disease in diabetes.

MeSH Terms
Animals Arteriosclerosis/etiology,physiopathology Diabetic Angiopathies/complications,physiopathology Glycation End Products, Advanced/physiology Humans
Chemicals
Glycation End Products, Advanced
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Schmidt A M
Department of Surgery, College of Physicians & Surgeons of Columbia University, 630 West 168th Street, New York, New York 10032, USA.
Stern D
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34 references, click to expand
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Article Info
Journal
Current atherosclerosis reports
Abbr.
Curr Atheroscler Rep
ISSN
1523-3804
DOI
10.1007/s11883-000-0082-4
Published
2000-09-00
Pages
430-6
Language
English
Region
United States
NLM ID
100897685
Subset
IM
External Links
PubMed source DOI: 10.1007/s11883-000-0082-4 View journal details
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