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PMID: 111544 Published · ppublish English Comparative Study Journal Article Review

Heterochromatin and satellite DNA in man: properties and prospects.

American journal of human genetics ·Vol. 31 ·No. 3 ·1979-05-00 ·Pages 264-80

Miklos GL, John B

Abstract

In reviewing the properties of heterochromatin and satellite DNA in man, it is clear that the human genome does not readily lend itself to experimental tests of the postulated functions for satellite DNA. Since the spectrum of known structural properties of vertebrate and invertebrate satellite DNAs are broadly overlapping, an alternative avenue is to experimentally manipulate the heterochromatin of an organism, and then evaluate the generality of the results. When this is done in Drosophila melanogaster, the one organism where such an experimental approach is indeed possible, the results provide no support for most of the popular hypotheses concerning satellite DNA function. They do, however, reveal an important effect on the meiotic system, namely that the position of crossover events can be markedly altered in the presence of heterochromatin known to be rich in satellite DNAs. This effect is not peculiar to Drosophila, since supporting data are readily available from natural situations in both mammals and grasshoppers. In all such cases, the effects are most easily discernible where the heterochromatic blocks are substantial in size, and non-centric in location, situations which do not apply in man. The human system, however, offers other potentials. The ubiquity of naturally occurring heterochromatic polymorphisms, coupled with the extreme sensitivity of the human genome to perturbation, offers some scope for assessing the possible somatic effects of alterations in the amount of satellite DNA.

MeSH Terms
Animals Chromosome Banding Chromosomes, Human Crossing Over, Genetic DNA/genetics DNA, Satellite/genetics Drosophila melanogaster/genetics Female Grasshoppers/genetics Heterochromatin/genetics Humans Male Meiosis Mice
Chemicals
DNA, Satellite Heterochromatin DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Miklos G L
John B
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63 references, click to expand
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1979-05-00
Pages
264-80
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1685796
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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