Home LiteratureArticle Details
PMID: 11201787 Published · ppublish English Journal Article Review

Lipid membrane domains in cell surface and vacuolar systems.

Glycoconjugate journal ·Vol. 17 ·No. 3 -4 ·2000-00-00 ·Pages 163-71

Kobayashi T, Hirabayashi Y

Abstract

Detergent insoluble sphingolipid-cholesterol enriched 'raft'-like membrane microdomains have been implicated in a variety of biological processes including sorting, trafficking, and signaling. Mutant cells and knockout animals of sphingolipid biosynthesis are clearly useful to understand the biological roles of lipid components in raft-like domains. It is suggested that raft-like domains distribute in internal vacuolar membranes as well as plasma membranes. In addition to sphingolipid-cholesterol-rich membrane domains, recent studies suggest the existence of another lipid-membrane domain in the endocytic pathway. This domain is enriched with a unique phospholipid, lysobisphosphatidic acid (LBPA) and localized in the internal membrane of multivesicular endosome. LBPA-rich membrane domains are involved in lipid and protein sorting within the endosomal system. Possible interaction between sphingolipids and LBPA in sphingolipid-storage disease is discussed.

MeSH Terms
Animals Cell Membrane/metabolism Drug Resistance, Multiple Endosomes/metabolism Glucosylceramides/metabolism Golgi Apparatus/metabolism Humans Membrane Lipids/genetics,metabolism Mutation Sphingolipids/metabolism Vacuoles/metabolism
Chemicals
Glucosylceramides Membrane Lipids Sphingolipids
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kobayashi T
Supra-Biomolecular System Research Group, Frontier Research System, The Institute of Physical and Chemical Research (RIKEN), Wako-shi, Saitama, Japan. [email protected]
Hirabayashi Y
References (108)
108 references, click to expand
  1. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine.
    Cell. 1996 Nov 1;87(3):507-17 PMID: 8898203
  2. Functional dissection of COP-I subunits in the biogenesis of multivesicular endosomes.
    J Cell Biol. 1997 Dec 1;139(5):1183-95 PMID: 9382865
  3. Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells.
    J Biol Chem. 1997 Jan 17;272(3):1682-7 PMID: 8999846
  4. Antibodies against phospholipids other than cardiolipin: potential roles for both phospholipid and protein.
    Lupus. 1996 Oct;5(5):498-502 PMID: 8902790
  5. Cytoplasmic dynein-dependent vesicular transport from early to late endosomes.
    J Cell Biol. 1993 Dec;123(6 Pt 1):1373-87 PMID: 8253838
  6. Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules.
    Blood. 1999 Dec 1;94(11):3791-9 PMID: 10572093
  7. Topology of glucosylceramide synthesis in Golgi membranes from porcine submaxillary glands.
    Biochim Biophys Acta. 1986 Jun 13;858(1):6-12 PMID: 2939881
  8. Intracellular site of asialoglycoprotein receptor-ligand uncoupling: double-label immunoelectron microscopy during receptor-mediated endocytosis.
    Cell. 1983 Jan;32(1):277-87 PMID: 6130851
  9. (Glyco)sphingolipids are sorted in sub-apical compartments in HepG2 cells: a role for non-Golgi-related intracellular sites in the polarized distribution of (glyco)sphingolipids.
    J Cell Biol. 1998 Aug 10;142(3):683-96 PMID: 9700158
  10. Cholesterol modulates membrane traffic along the endocytic pathway in sphingolipid-storage diseases.
    Nat Cell Biol. 1999 Oct;1(6):386-8 PMID: 10559968
  11. Lipids of alveolar macrophages, polymorphonuclear leukocytes, and their phagocytic vesicles.
    J Clin Invest. 1972 Sep;51(9):2399-407 PMID: 4344731
  12. Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73.
    J Cell Biol. 1999 Nov 1;147(3):599-610 PMID: 10545503
  13. Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors.
    Annu Rev Biochem. 1992;61:307-30 PMID: 1323236
  14. The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells.
    Mol Biol Cell. 2000 May;11(5):1829-43 PMID: 10793155
  15. Mutations in the leucine zipper motif and sterol-sensing domain inactivate the Niemann-Pick C1 glycoprotein.
    J Biol Chem. 1999 Jul 30;274(31):21861-6 PMID: 10419504
  16. Glycosphingolipids are not essential for formation of detergent-resistant membrane rafts in melanoma cells. methyl-beta-cyclodextrin does not affect cell surface transport of a GPI-anchored protein.
    J Biol Chem. 1999 Nov 26;274(48):34459-66 PMID: 10567427
  17. The importance of the endosome in intracellular traffic.
    Nature. 1983 Aug 25-31;304(5928):684-5 PMID: 6310401
  18. Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments.
    Cell. 1990 Jul 27;62(2):317-29 PMID: 2115402
  19. Separation of "glycosphingolipid signaling domain" from caveolin-containing membrane fraction in mouse melanoma B16 cells and its role in cell adhesion coupled with signaling.
    J Biol Chem. 1998 Dec 11;273(50):33766-73 PMID: 9837965
  20. Caveolar structure and protein sorting are maintained in NIH 3T3 cells independent of glycosphingolipid depletion.
    Arch Biochem Biophys. 2000 Jan 1;373(1):83-90 PMID: 10620326
  21. Functions of lipid rafts in biological membranes.
    Annu Rev Cell Dev Biol. 1998;14:111-36 PMID: 9891780
  22. Intracellular transport of ceramide and its metabolites at the Golgi complex: insights from short-chain analogs.
    Adv Lipid Res. 1993;26:101-18 PMID: 8379446
  23. Subcellular distributions of lipids in cultured BHK cells: evidence for the enrichment of lysobisphosphatidic acid and neutral lipids in lysosomes.
    J Lipid Res. 1977 Mar;18(2):191-202 PMID: 845501
  24. Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells.
    J Biol Chem. 1999 Jan 8;274(2):1140-6 PMID: 9873062
  25. Microdomains of GPI-anchored proteins in living cells revealed by crosslinking.
    Nature. 1998 Aug 20;394(6695):802-5 PMID: 9723622
  26. Interaction of anti-phospholipid antibodies with late endosomes of human endothelial cells.
    Arterioscler Thromb Vasc Biol. 2000 Feb;20(2):563-74 PMID: 10669657
  27. Ceramide as a modulator of endocytosis.
    J Biol Chem. 1995 Jun 2;270(22):13291-7 PMID: 7768929
  28. Introduction: protein and lipid sorting in the secretory and endocytic pathways-receptors and mechanisms
    Semin Cell Dev Biol. 1998 Oct;9(5):491-2 PMID: 9835635
  29. The antiphospholipid-protein syndrome.
    J Clin Immunol. 1995 Nov;15(6 Suppl):86S-100S PMID: 8613497
  30. A mouse B16 melanoma mutant deficient in glycolipids.
    Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2703-7 PMID: 8146177
  31. Trafficking of glycosphingolipids in eukaryotic cells; sorting and recycling of lipids.
    Biochim Biophys Acta. 1992 Dec 11;1113(3-4):277-94 PMID: 1450202
  32. Cholesterol-dependent retention of GPI-anchored proteins in endosomes.
    EMBO J. 1998 Aug 17;17(16):4626-38 PMID: 9707422
  33. Glucosylceramide is synthesized at the cytosolic surface of various Golgi subfractions.
    J Cell Biol. 1992 Apr;117(2):259-67 PMID: 1532799
  34. Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro.
    J Cell Biol. 1989 Apr;108(4):1301-16 PMID: 2538480
  35. The tetraspanin superfamily: molecular facilitators.
    FASEB J. 1997 May;11(6):428-42 PMID: 9194523
  36. Glycerol reorientation during the conversion of phosphatidylglycerol to bis(monoacylglycerol)phosphate in macrophage-like RAW 264.7 cells.
    J Biol Chem. 1991 Apr 15;266(11):6834-40 PMID: 2016299
  37. Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process.
    J Cell Biol. 1993 Jun;121(6):1257-69 PMID: 8509447
  38. Endocytosis, intracellular transport, and cytotoxic action of Shiga toxin and ricin.
    Physiol Rev. 1996 Oct;76(4):949-66 PMID: 8874490
  39. B lymphocytes secrete antigen-presenting vesicles.
    J Exp Med. 1996 Mar 1;183(3):1161-72 PMID: 8642258
  40. The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules.
    J Immunol. 1998 Oct 1;161(7):3282-91 PMID: 9759843
  41. Glucosylceramide synthase and glycosphingolipid synthesis.
    Trends Cell Biol. 1998 May;8(5):198-202 PMID: 9695839
  42. Complete removal of sphingolipids from the plasma membrane disrupts cell to substratum adhesion of mouse melanoma cells.
    J Biol Chem. 1996 Jun 14;271(24):14636-41 PMID: 8662871
  43. Enrichment of bis-(monoacylglyceryl) phosphate in lysosomes from rat liver.
    J Biol Chem. 1972 Jul 10;247(13):4114-20 PMID: 4338481
  44. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface.
    Cell. 1992 Feb 7;68(3):533-44 PMID: 1531449
  45. Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis.
    Science. 1997 Jul 11;277(5323):228-31 PMID: 9211849
  46. Transport of newly synthesized glucosylceramide to the plasma membrane by a non-Golgi pathway.
    Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2708-12 PMID: 8146178
  47. Accumulation of glucosylceramides in multidrug-resistant cancer cells.
    J Biol Chem. 1996 Aug 9;271(32):19530-6 PMID: 8702646
  48. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.
    Science. 1998 Mar 6;279(5356):1552-5 PMID: 9488656
  49. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.
    Cell. 1999 Oct 29;99(3):301-12 PMID: 10555146
  50. Intracellular transport of GPI-anchored proteins.
    EMBO J. 2000 Jan 4;19(1):10-5 PMID: 10619839
  51. Specific release of membrane-bound annexin II and cortical cytoskeletal elements by sequestration of membrane cholesterol.
    Mol Biol Cell. 1997 Mar;8(3):533-45 PMID: 9188103
  52. Novel stereoconfiguration in lyso-bis-phosphatidic acid of cultured BHK-cells.
    Chem Phys Lipids. 1974 Oct;13(2):178-82 PMID: 4473276
  53. Current insights into the "antiphospholipid" syndrome: clinical, immunological, and molecular aspects.
    Adv Immunol. 1998;70:507-63 PMID: 9755344
  54. Genetic evidence for ATP-dependent endoplasmic reticulum-to-Golgi apparatus trafficking of ceramide for sphingomyelin synthesis in Chinese hamster ovary cells.
    J Cell Biol. 1999 Feb 22;144(4):673-85 PMID: 10037789
  55. Changes in the spectral properties of a plasma membrane lipid analog during the first seconds of endocytosis in living cells.
    Biophys J. 1997 Jan;72(1):37-50 PMID: 8994591
  56. The mannose 6-phosphate receptor and the biogenesis of lysosomes.
    Cell. 1988 Feb 12;52(3):329-41 PMID: 2964276
  57. Endosomes differ from plasma membranes in the phospholipid molecular species composition.
    Biochim Biophys Acta. 1988 Dec 8;946(1):151-63 PMID: 3264726
  58. Functional rafts in cell membranes.
    Nature. 1997 Jun 5;387(6633):569-72 PMID: 9177342
  59. The role of endosomes and lysosomes in MHC class II functioning.
    Immunol Today. 1998 Jun;19(6):282-7 PMID: 9639994
  60. Up-regulation of caveolae and caveolar constituents in multidrug-resistant cancer cells.
    J Biol Chem. 1998 Dec 4;273(49):32380-3 PMID: 9829965
  61. Mobilization of late-endosomal cholesterol is inhibited by Rab guanine nucleotide dissociation inhibitor.
    Curr Biol. 2000 Jan 27;10(2):95-8 PMID: 10662671
  62. Elevation of intracellular glucosylceramide levels results in an increase in endoplasmic reticulum density and in functional calcium stores in cultured neurons.
    J Biol Chem. 1999 Jul 30;274(31):21673-8 PMID: 10419477
  63. Ceramide: an intracellular signal for apoptosis.
    Trends Biochem Sci. 1995 Feb;20(2):73-7 PMID: 7701566
  64. Topography of glycosyltransferases involved in the initial glycosylations of gangliosides.
    J Biol Chem. 1991 Nov 5;266(31):20907-12 PMID: 1834652
  65. Salvage of glucosylceramide by recycling after internalization along the pathway of receptor-mediated endocytosis.
    Proc Natl Acad Sci U S A. 1989 Dec;86(24):9896-900 PMID: 2690077
  66. Regulation of ceramide production and apoptosis.
    Annu Rev Physiol. 1998;60:643-65 PMID: 9558480
  67. Polarized sphingolipid transport from the subapical compartment: evidence for distinct sphingolipid domains.
    Mol Biol Cell. 1999 Oct;10 (10 ):3449-61 PMID: 10512879
  68. Lipids, lipid domains and lipid-protein interactions in endocytic membrane traffic.
    Semin Cell Dev Biol. 1998 Oct;9(5):517-26 PMID: 9835639
  69. Multivesicular body morphogenesis requires phosphatidyl-inositol 3-kinase activity.
    Curr Biol. 1999 Jan 14;9(1):55-8 PMID: 9889123
  70. The structure of organelles of the endocytic pathway in hydrated cryosections of cultured cells.
    Eur J Cell Biol. 1989 Aug;49(2):281-94 PMID: 2476311
  71. Role of Niemann-Pick type C1 protein in intracellular trafficking of low density lipoprotein-derived cholesterol.
    J Biol Chem. 2000 Feb 11;275(6):4013-21 PMID: 10660558
  72. The annexins and exocytosis.
    Science. 1992 Nov 6;258(5084):924-31 PMID: 1439804
  73. Induction of endocytic vesicles by exogenous C(6)-ceramide.
    J Biol Chem. 1999 Jul 23;274(30):21121-7 PMID: 10409665
  74. Oligomerization and topology of the Golgi membrane protein glucosylceramide synthase.
    J Biol Chem. 1999 Jan 1;274(1):451-6 PMID: 9867864
  75. Regulation of arachidonic acid metabolism in resident and BCG-activated alveolar macrophages: role of lyso(bis)phosphatidic acid.
    J Immunol. 1987 Mar 15;138(6):1877-83 PMID: 3102603
  76. Lipid recycling between the plasma membrane and intracellular compartments: transport and metabolism of fluorescent sphingomyelin analogues in cultured fibroblasts.
    J Cell Biol. 1989 Jun;108(6):2169-81 PMID: 2738091
  77. Segregation of glucosylceramide and sphingomyelin occurs in the apical to basolateral transcytotic route in HepG2 cells.
    J Cell Biol. 1997 Apr 21;137(2):347-57 PMID: 9128247
  78. Multivesicular bodies in HEp-2 cells are maturing endosomes.
    Eur J Cell Biol. 1993 Aug;61(2):208-24 PMID: 8223712
  79. Immunology of the antiphospholipid antibody syndrome.
    Arthritis Rheum. 1996 Sep;39(9):1444-54 PMID: 8814055
  80. Lipid sorting in epithelial cells.
    Biochemistry. 1988 Aug 23;27(17):6197-202 PMID: 3064805
  81. Gangliosides are transported from the plasma membrane to intralysosomal membranes as revealed by immuno-electron microscopy.
    Biosci Rep. 1999 Aug;19(4):307-16 PMID: 10589996
  82. Functionally different GPI proteins are organized in different domains on the neuronal surface.
    EMBO J. 1999 Dec 15;18(24):6917-26 PMID: 10601014
  83. Annexin II is a major component of fusogenic endosomal vesicles.
    J Cell Biol. 1993 Mar;120(6):1357-69 PMID: 8449982
  84. Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: receptor pathway.
    J Cell Biol. 1986 Jan;102(1):24-36 PMID: 3001101
  85. Sphingomyelin breakdown and cell fate.
    Trends Biochem Sci. 1996 Dec;21(12 ):468-71 PMID: 9009829
  86. Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization.
    Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):805-10 PMID: 9927649
  87. Broad screening test for sphingolipid-storage diseases.
    Lancet. 1999 Sep 11;354(9182):901-5 PMID: 10489949
  88. A lipid associated with the antiphospholipid syndrome regulates endosome structure and function.
    Nature. 1998 Mar 12;392(6672):193-7 PMID: 9515966
  89. New insights into the interaction of Ras with the plasma membrane.
    Cell. 1999 Jul 9;98(1):9-12 PMID: 10412976
  90. Both sphingolipids and cholesterol participate in the detergent insolubility of alkaline phosphatase, a glycosylphosphatidylinositol-anchored protein, in mammalian membranes.
    J Biol Chem. 1995 Mar 17;270(11):6254-60 PMID: 7890763
  91. A vital role for glycosphingolipid synthesis during development and differentiation.
    Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9142-7 PMID: 10430909
  92. Functions of ceramide in coordinating cellular responses to stress.
    Science. 1996 Dec 13;274(5294):1855-9 PMID: 8943189
  93. Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene.
    Science. 1997 Jul 11;277(5323):232-5 PMID: 9211850
  94. Sorting of sphingolipids in the endocytic pathway of HT29 cells.
    J Cell Biol. 1991 Jul;114(2):231-9 PMID: 2071671
  95. The differential miscibility of lipids as the basis for the formation of functional membrane rafts.
    Biochim Biophys Acta. 1998 Nov 10;1376(3):467-79 PMID: 9805010
  96. Parasitophorous vacuoles of Leishmania mexicana acquire macromolecules from the host cell cytosol via two independent routes.
    J Cell Sci. 1999 Mar;112 ( Pt 5):681-93 PMID: 9973603
  97. Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior.
    Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12130-4 PMID: 7991596
  98. GPI-anchored proteins are organized in submicron domains at the cell surface.
    Nature. 1998 Aug 20;394(6695):798-801 PMID: 9723621
  99. Internalization and sorting of plasma membrane sphingolipid analogues in differentiating oligodendrocytes.
    J Neurochem. 1999 Oct;73(4):1375-83 PMID: 10501180
  100. Annexin II tetramer: structure and function.
    Mol Cell Biochem. 1995 Aug-Sep;149-150:301-22 PMID: 8569746
  101. Determination of the intracellular sites and topology of glucosylceramide synthesis in rat liver.
    Biochem J. 1991 Dec 1;280 ( Pt 2):295-302 PMID: 1747103
  102. The subcellular distribution of early endosomes is affected by the annexin II2p11(2) complex.
    J Cell Biol. 1993 Dec;123(5):1119-32 PMID: 8245122
  103. Localization of Niemann-Pick C1 protein in astrocytes: implications for neuronal degeneration in Niemann- Pick type C disease.
    Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1657-62 PMID: 9990080
  104. Membrane microdomains and caveolae.
    Curr Opin Cell Biol. 1999 Aug;11(4):424-31 PMID: 10449327
  105. Phospholipid, cholesterol, polypeptide and glycoprotein composition of hepatic endosome subfractions.
    Biochem J. 1985 Nov 15;232(1):33-6 PMID: 2867761
  106. Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport.
    Nat Cell Biol. 1999 Jun;1(2):113-8 PMID: 10559883
  107. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes.
    J Biol Chem. 1998 Aug 7;273(32):20121-7 PMID: 9685355
  108. Ceramide signalling and the immune response.
    Biochim Biophys Acta. 1996 Jun 11;1301(3):273-87 PMID: 8664339
Article Info
Journal
Glycoconjugate journal
Abbr.
Glycoconj J
ISSN
0282-0080
DOI
10.1023/a:1026528921085
Email
[email protected]
Published
2000-00-00
Pages
163-71
Language
English
Region
United States
NLM ID
8603310
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1026528921085 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2