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PMID: 11265750 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Mini- and microsatellite expansions: the recombination connection.

EMBO reports ·Vol. 1 ·No. 2 ·2000-08-00 ·Pages 122-6

Richard GF, Pâques F

Abstract

It is widely accepted that the large trinucleotide repeat expansions observed in many neurological diseases occur during replication. However, genetic recombination has emerged as a major source of instability for tandem repeats, including minisatellites, and recent studies raise the possibility that it may also be responsible for trinucleotide repeat expansions. We will review data connecting tandem repeat rearrangements and recombination in humans and in eukaryotic model organisms, and discuss the possible role of recombination in trinucleotide repeat expansions in human neurological disorders.

MeSH Terms
Animals DNA/genetics DNA Repair Gene Conversion Humans Meiosis/genetics,physiology Minisatellite Repeats Models, Genetic Recombination, Genetic/genetics Tandem Repeat Sequences/genetics Trinucleotide Repeat Expansion
Chemicals
DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Richard G F
Unité de Génétique Moléculaire des Levures, URA 2171 CNRS, Paris, France. [email protected]
Pâques F
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Article Info
Journal
EMBO reports
Abbr.
EMBO Rep
ISSN
1469-221X
DOI
10.1093/embo-reports/kvd031
Email
[email protected]
Published
2000-08-00
Pages
122-6
Language
English
Region
England
NLM ID
100963049
PMCID
PMC1084263
Subset
IM
External Links
PubMed source DOI: 10.1093/embo-reports/kvd031 PMC Full Text View journal details
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