Home LiteratureArticle Details
PMID: 11412300 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Siglecs in the immune system.

Immunology ·Vol. 103 ·No. 2 ·2001-06-00 ·Pages 137-45

Crocker PR, Varki A

Abstract

暂无摘要

MeSH Terms
Animals Antigens, CD/immunology Antigens, Differentiation, B-Lymphocyte/immunology Antigens, Differentiation, Myelomonocytic/immunology B-Lymphocytes/immunology Cell Adhesion Molecules Cell Communication/immunology Humans Immune System/immunology Lectins/immunology Mice N-Acetylneuraminic Acid/immunology Sialic Acid Binding Ig-like Lectin 2 Sialic Acid Binding Ig-like Lectin 3 Sialic Acid Binding Immunoglobulin-like Lectins Signal Transduction/immunology
Chemicals
Antigens, CD Antigens, Differentiation, B-Lymphocyte Antigens, Differentiation, Myelomonocytic CD22 protein, human CD33 protein, human Cd22 protein, mouse Cd33 protein, mouse Cell Adhesion Molecules Lectins Sialic Acid Binding Ig-like Lectin 2 Sialic Acid Binding Ig-like Lectin 3 Sialic Acid Binding Immunoglobulin-like Lectins N-Acetylneuraminic Acid
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Crocker P R
The Wellcome Trust Biocentre at Dundee, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. [email protected]
Varki A
References (82)
82 references, click to expand
  1. CD22 is a negative regulator of B-cell receptor signalling.
    Curr Biol. 1997 Feb 1;7(2):133-43 PMID: 9016707
  2. Tuning antigen receptor signaling by CD22: integrating cues from antigens and the microenvironment.
    Immunity. 1997 May;6(5):509-17 PMID: 9175829
  3. Sialic acids in molecular and cellular interactions.
    Int Rev Cytol. 1997;175:137-240 PMID: 9203358
  4. Binding of human plasma sialoglycoproteins by the B cell-specific lectin CD22. Selective recognition of immunoglobulin M and haptoglobin.
    J Biol Chem. 1995 Mar 31;270(13):7543-50 PMID: 7706301
  5. Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules.
    Blood. 1995 Apr 15;85(8):2005-12 PMID: 7718872
  6. Regulation of CD45 engagement by the B-cell receptor CD22.
    Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):4026-30 PMID: 7537381
  7. I-type lectins.
    J Biol Chem. 1995 Jun 16;270(24):14243-6 PMID: 7782275
  8. A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP.
    Science. 1995 Jul 14;269(5221):242-4 PMID: 7618087
  9. Ig domains 1 and 2 of murine CD22 constitute the ligand-binding domain and bind multiple sialylated ligands expressed on B and T cells.
    J Immunol. 1995 Oct 1;155(7):3368-76 PMID: 7561031
  10. Myelin-associated glycoprotein: a role in myelination and in the inhibition of axonal regeneration?
    Curr Opin Neurobiol. 1995 Oct;5(5):588-95 PMID: 8580710
  11. Cryptic sialic acid binding lectins on human blood leukocytes can be unmasked by sialidase treatment or cellular activation.
    Glycobiology. 1999 Nov;9(11):1225-34 PMID: 10536038
  12. The sialoadhesin CD33 is a myeloid-specific inhibitory receptor.
    Eur J Immunol. 1999 Nov;29(11):3440-9 PMID: 10556798
  13. Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes.
    J Biol Chem. 1999 Nov 26;274(48):34089-95 PMID: 10567377
  14. Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47.
    Blood. 1999 Dec 1;94(11):3633-43 PMID: 10572074
  15. Macrophage-tumour cell interactions: identification of MUC1 on breast cancer cells as a potential counter-receptor for the macrophage-restricted receptor, sialoadhesin.
    Immunology. 1999 Oct;98(2):213-9 PMID: 10610356
  16. Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells.
    Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15091-6 PMID: 10611343
  17. Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily.
    J Biol Chem. 2000 Jan 14;275(2):861-6 PMID: 10625619
  18. New aspects of siglec binding specificities, including the significance of fucosylation and of the sialyl-Tn epitope. Sialic acid-binding immunoglobulin superfamily lectins.
    J Biol Chem. 2000 Mar 24;275(12):8625-32 PMID: 10722702
  19. Counterregulation by the coreceptors CD19 and CD22 of MAP kinase activation by membrane immunoglobulin.
    Immunity. 1997 Jul;7(1):59-67 PMID: 9252120
  20. Inhibition of the B cell by CD22: a requirement for Lyn.
    J Exp Med. 1998 Mar 2;187(5):807-11 PMID: 9480991
  21. Siglecs: a family of sialic-acid binding lectins.
    Glycobiology. 1998 Feb;8(2):v PMID: 9498912
  22. Immune regulation by the ST6Gal sialyltransferase.
    Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4504-9 PMID: 9539767
  23. Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes.
    Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7469-74 PMID: 9636173
  24. Crystal structure of the N-terminal domain of sialoadhesin in complex with 3' sialyllactose at 1.85 A resolution.
    Mol Cell. 1998 Apr;1(5):719-28 PMID: 9660955
  25. Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33.
    Blood. 1998 Sep 15;92(6):2123-32 PMID: 9731071
  26. Functional groups of sialic acids involved in binding to siglecs (sialoadhesins) deduced from interactions with synthetic analogues.
    Eur J Biochem. 1998 Aug 1;255(3):663-72 PMID: 9738906
  27. Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene.
    Nat Genet. 1998 Oct;20(2):129-35 PMID: 9771704
  28. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM.
    Nature. 1998 Oct 1;395(6701):462-9 PMID: 9774102
  29. Integrin-associated protein is a ligand for the P84 neural adhesion molecule.
    J Biol Chem. 1999 Jan 8;274(2):559-62 PMID: 9872987
  30. The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2.
    J Biol Chem. 1999 Apr 23;274(17):11505-12 PMID: 10206955
  31. Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies.
    J Exp Med. 1999 Apr 19;189(8):1307-13 PMID: 10209047
  32. Identification of CD22 ligands on bone marrow sinusoidal endothelium implicated in CD22-dependent homing of recirculating B cells.
    J Exp Med. 1999 May 3;189(9):1513-8 PMID: 10224292
  33. Sialoadhesin-positive host macrophages play an essential role in graft-versus-leukemia reactivity in mice.
    Blood. 1999 Jun 15;93(12):4375-86 PMID: 10361136
  34. Analysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22.
    J Biol Chem. 1999 Jun 25;274(26):18769-76 PMID: 10373493
  35. OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily.
    J Biol Chem. 1999 Aug 6;274(32):22729-38 PMID: 10428856
  36. Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells.
    J Exp Med. 1999 Sep 20;190(6):793-802 PMID: 10499918
  37. mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2.
    Biochem J. 2001 Feb 1;353(Pt 3):483-92 PMID: 11171044
  38. Initial sequencing and analysis of the human genome.
    Nature. 2001 Feb 15;409(6822):860-921 PMID: 11237011
  39. Cutting edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor sialoadhesin (Siglec-1).
    J Immunol. 2001 Mar 15;166(6):3637-40 PMID: 11238599
  40. Putting the brakes on innate immunity: a regulatory role for CD200?
    Nat Immunol. 2001 Jan;2(1):17-9 PMID: 11135572
  41. Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor.
    Biochem J. 2001 Apr 15;355(Pt 2):489-97 PMID: 11284738
  42. Molecular cloning of MIS, a myeloid inhibitory siglec, that binds protein-tyrosine phosphatases SHP-1 and SHP-2.
    J Biol Chem. 2001 Apr 27;276(17):14451-8 PMID: 11278955
  43. Properties and distribution of a lectin-like hemagglutinin differentially expressed by murine stromal tissue macrophages.
    J Exp Med. 1986 Dec 1;164(6):1862-75 PMID: 3783087
  44. The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion.
    Nature. 1990 May 3;345(6270):74-7 PMID: 1691828
  45. Purification and properties of sialoadhesin, a sialic acid-binding receptor of murine tissue macrophages.
    EMBO J. 1991 Jul;10(7):1661-9 PMID: 2050106
  46. CD22, a B cell-specific immunoglobulin superfamily member, is a sialic acid-binding lectin.
    J Biol Chem. 1993 Apr 5;268(10):7011-8 PMID: 8463234
  47. Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recognition.
    J Biol Chem. 1993 Apr 5;268(10):7019-27 PMID: 8463235
  48. CD22 associates with the human surface IgM-B-cell antigen receptor complex.
    Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3236-40 PMID: 8475064
  49. The same epitope on CD22 of B lymphocytes mediates the adhesion of erythrocytes, T and B lymphocytes, neutrophils, and monocytes.
    J Immunol. 1993 Jun 1;150(11):4719-32 PMID: 7684411
  50. Association of CD22 with the B cell antigen receptor.
    Eur J Immunol. 1993 Jun;23(6):1358-63 PMID: 7684686
  51. The oligosaccharide binding specificities of CD22 beta, a sialic acid-specific lectin of B cells.
    J Biol Chem. 1994 Apr 8;269(14):10628-36 PMID: 8144652
  52. Cytokine-induced beta-galactoside alpha-2,6-sialyltransferase in human endothelial cells mediates alpha 2,6-sialylation of adhesion molecules and CD22 ligands.
    J Biol Chem. 1994 Apr 8;269(14):10637-43 PMID: 8144653
  53. Molecular cloning of two isoforms of the murine homolog of the myeloid CD33 antigen.
    Blood. 1994 Jun 1;83(11):3188-98 PMID: 8193354
  54. Sialoadhesin, a macrophage sialic acid binding receptor for haemopoietic cells with 17 immunoglobulin-like domains.
    EMBO J. 1994 Oct 3;13(19):4490-503 PMID: 7925291
  55. Sialoadhesin binds preferentially to cells of the granulocytic lineage.
    J Clin Invest. 1995 Feb;95(2):635-43 PMID: 7532186
  56. Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily.
    Curr Biol. 1994 Nov 1;4(11):965-72 PMID: 7533044
  57. Modifications of cell surface sialic acids modulate cell adhesion mediated by sialoadhesin and CD22.
    Glycoconj J. 1994 Dec;11(6):576-85 PMID: 7696861
  58. Apoptosis and macrophage-mediated cell deletion in the regulation of B lymphopoiesis in mouse bone marrow.
    Immunol Rev. 1994 Dec;142:209-30 PMID: 7698795
  59. CD22-mediated cell adhesion to cytokine-activated human endothelial cells. Positive and negative regulation by alpha 2-6-sialylation of cellular glycoproteins.
    J Biol Chem. 1995 Mar 31;270(13):7533-42 PMID: 7706300
  60. Loss of N-glycolylneuraminic acid in human evolution. Implications for sialic acid recognition by siglecs.
    J Biol Chem. 2000 Mar 24;275(12):8633-40 PMID: 10722703
  61. Engagement of CD33 surface molecules prevents the generation of dendritic cells from both monocytes and CD34+ myeloid precursors.
    Eur J Immunol. 2000 Mar;30(3):827-33 PMID: 10741398
  62. Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.
    Glycobiology. 2000 Apr;10(4):431-8 PMID: 10764831
  63. CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.
    J Biol Chem. 2000 Jun 9;275(23):17420-7 PMID: 10748054
  64. Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils.
    J Allergy Clin Immunol. 2000 Jun;105(6 Pt 1):1093-100 PMID: 10856141
  65. Role of CD47 as a marker of self on red blood cells.
    Science. 2000 Jun 16;288(5473):2051-4 PMID: 10856220
  66. Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2.
    Blood. 2000 Jul 15;96(2):483-90 PMID: 10887109
  67. Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels.
    Immunity. 2000 Jun;12(6):665-76 PMID: 10894166
  68. Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes.
    J Biol Chem. 2000 Jul 21;275(29):22121-6 PMID: 10801862
  69. Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways.
    J Biol Chem. 2000 Jul 21;275(29):22127-35 PMID: 10801860
  70. Identification and molecular characterization of a novel member of the siglec family (SIGLEC9).
    Genomics. 2000 Jul 15;67(2):171-8 PMID: 10903842
  71. CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPalpha 1.
    Eur J Immunol. 2000 Aug;30(8):2130-7 PMID: 10940903
  72. Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function.
    Immunity. 2000 Aug;13(2):233-42 PMID: 10981966
  73. Immune inhibitory receptors.
    Science. 2000 Oct 6;290(5489):84-9 PMID: 11021804
  74. Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene.
    Biochem Biophys Res Commun. 2000 Nov 30;278(3):775-81 PMID: 11095983
  75. Down-regulation of the macrophage lineage through interaction with OX2 (CD200).
    Science. 2000 Dec 1;290(5497):1768-71 PMID: 11099416
  76. A novel subset of murine B cells that expresses unmasked forms of CD22 is enriched in the bone marrow: implications for B-cell homing to the bone marrow.
    Immunology. 2000 Nov;101(3):342-7 PMID: 11106937
  77. Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations.
    Blood. 2001 Jan 1;97(1):288-96 PMID: 11133773
  78. Localization of the putative sialic acid-binding site on the immunoglobulin superfamily cell-surface molecule CD22.
    J Biol Chem. 1996 Apr 19;271(16):9273-80 PMID: 8621588
  79. Hyperresponsive B cells in CD22-deficient mice.
    Science. 1996 Nov 1;274(5288):798-801 PMID: 8864124
  80. Sialic acid 9-O-acetylation on murine erythroleukemia cells affects complement activation, binding to I-type lectins, and tissue homing.
    J Biol Chem. 1996 Dec 6;271(49):31526-32 PMID: 8940168
  81. CD22 regulates thymus-independent responses and the lifespan of B cells.
    Nature. 1996 Dec 19-26;384(6610):634-7 PMID: 8967951
  82. CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice.
    Immunity. 1996 Dec;5(6):551-62 PMID: 8986715
Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
2001-06-00
Pages
137-45
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1783234
Subset
IM
Grants
NIGMS NIH HHS · R37 GM032373 · United States
NIGMS NIH HHS · R01 GM032373 · United States
NIGMS NIH HHS · GM32373 · United States
NHLBI NIH HHS · HL57345 · United States
NHLBI NIH HHS · P01 HL057345 · United States
Wellcome Trust · United Kingdom
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]