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PMID: 11447210 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Mannan-binding lectin enhances susceptibility to visceral leishmaniasis.

Infection and immunity ·Vol. 69 ·No. 8 ·2001-08-00 ·Pages 5212-5

Santos IK, Costa CH, Krieger H, Feitosa MF, Zurakowski D, Fardin B, Gomes RB, Weiner DL, Harn DA, Ezekowitz RA, Epstein JE

Abstract

Levels of the serum opsonin mannan-binding lectin (MBL) were directly correlated with the probability of developing visceral leishmaniasis. Monocytes infected with MBL-opsonized Leishmania chagasi promastigotes secreted higher levels of tumor necrosis factor alpha and interleukin-6 than cells infected with nonopsonized parasites. Our findings indicate that MBL can modulate the clinical outcome of infection with L. chagasi and the function of infected macrophages.

MeSH Terms
Adolescent Adult Aged Aged, 80 and over Animals Carrier Proteins/blood,genetics,immunology,pharmacology Case-Control Studies Child Child, Preschool Collectins Disease Susceptibility Humans Infant Interleukin-6/metabolism Lectins/genetics,immunology,pharmacology Leishmania infantum/genetics,immunology,isolation & purification Leishmaniasis, Visceral/blood,immunology,parasitology Mannans Middle Aged Opsonin Proteins/genetics,immunology,pharmacology Tumor Cells, Cultured Tumor Necrosis Factor-alpha/metabolism
Chemicals
Carrier Proteins Collectins Interleukin-6 Lectins Mannans Opsonin Proteins Tumor Necrosis Factor-alpha
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Santos I K
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Children's Hospital, Boston, Massachusetts 02115, USA.
Costa C H
Krieger H
Feitosa M F
Zurakowski D
Fardin B
Gomes R B
Weiner D L
Harn D A
Ezekowitz R A
Epstein J E
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.69.8.5212-5215.2001
Published
2001-08-00
Pages
5212-5
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC98624
Subset
IM
Grants
NICHD NIH HHS · K12 HD000850 · United States
NICHD NIH HHS · K12-HD00850 · United States
External Links
PubMed source DOI: 10.1128/IAI.69.8.5212-5215.2001 PMC Full Text View journal details
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