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PMID: 9053446 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells.

The Journal of experimental medicine ·Vol. 185 ·No. 3 ·1997-02-03 ·Pages 461-9

Rincón M, Anguita J, Nakamura T, Fikrig E, Flavell RA

Abstract

Interleukin (IL)-4 is the most potent factor that causes naive CD4+ T cells to differentiate to the T helper cell (Th) 2 phenotype, while IL-12 and interferon gamma trigger the differentiation of Th1 cells. However, the source of the initial polarizing IL-4 remains unclear. Here, we show that IL-6, probably secreted by antigen-presenting cells, is able to polarize naive CD4+ T cells to effector Th2 cells by inducing the initial production of IL-4 in CD4+ T cells. These results show that the nature of the cytokine (IL-12 or IL-6), which is produced by antigen-presenting cells in response to a particular pathogen, is a key factor in determining the nature of the immune response.

MeSH Terms
Animals Antigen-Presenting Cells/physiology CD4-Positive T-Lymphocytes/drug effects,physiology Cell Differentiation/drug effects Interleukin-4/biosynthesis Interleukin-6/pharmacology Mice Mice, Inbred C57BL
Chemicals
Interleukin-6 Interleukin-4
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Rincón M
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA.
Anguita J
Nakamura T
Fikrig E
Flavell R A
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.185.3.461
Published
1997-02-03
Pages
461-9
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2196041
Subset
IM
Grants
NIAID NIH HHS · 1-P01-AI30548 · United States
NCI NIH HHS · CA65861 · United States
External Links
PubMed source DOI: 10.1084/jem.185.3.461 PMC Full Text View journal details
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